Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.051 -9999.0 0.0 -0.601 1.0 1.0 epithelial cell differentiation -0.007 0.059 -9999.0 0.0 -0.459 5.0 5.0 CYFIP2 -0.023 0.155 -9999.0 0.0 -0.71 17.0 17.0 ENAH 0.04 0.076 -9999.0 0.0 -0.424 3.0 3.0 EGFR -0.036 0.169 -9999.0 0.0 -0.619 27.0 27.0 EPHA2 -0.015 0.135 -9999.0 0.0 -0.675 14.0 14.0 MYO6 0.026 0.064 -9999.0 0.0 -0.73 1.0 1.0 CTNNB1 0.01 0.03 -9999.0 0.0 -0.546 1.0 1.0 ABI1/Sra1/Nap1 -0.022 0.097 -9999.0 0.0 -0.454 17.0 17.0 AQP5 -0.182 0.221 -9999.0 0.0 -0.547 86.0 86.0 CTNND1 0.01 0.038 -9999.0 0.0 -0.71 1.0 1.0 mol:PI-4-5-P2 0.027 0.059 -9999.0 0.0 -0.712 1.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.007 0.113 -9999.0 0.0 -0.712 1.0 1.0 EGF -0.122 0.276 -9999.0 0.0 -0.686 68.0 68.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.081 0.189 -9999.0 0.0 -0.559 45.0 45.0 cortical microtubule organization -0.007 0.059 -9999.0 0.0 -0.459 5.0 5.0 GO:0000145 0.026 0.056 -9999.0 0.0 -0.674 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.007 0.06 -9999.0 0.0 -0.465 5.0 5.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.022 0.086 -9999.0 0.0 -0.614 3.0 3.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.007 0.097 -9999.0 0.0 -0.41 16.0 16.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.035 0.064 -9999.0 0.0 -0.574 2.0 2.0 PVRL2 0.01 0.03 -9999.0 0.0 -0.546 1.0 1.0 ZYX 0.026 0.064 -9999.0 0.0 -0.73 1.0 1.0 ARF6/GTP -0.02 0.082 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.002 0.085 -9999.0 0.0 -0.71 5.0 5.0 EGFR/EGFR/EGF/EGF -0.093 0.175 -9999.0 0.0 -0.707 11.0 11.0 RhoA/GDP -0.007 0.055 -9999.0 0.0 -0.718 1.0 1.0 actin cytoskeleton organization 0.031 0.06 -9999.0 0.0 -0.679 1.0 1.0 IGF-1R heterotetramer 0.001 0.087 -9999.0 0.0 -0.654 6.0 6.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.001 0.087 -9999.0 0.0 -0.655 6.0 6.0 IGF1 -0.034 0.168 -9999.0 0.0 -0.638 25.0 25.0 DIAPH1 -0.032 0.138 -9999.0 0.0 -0.646 17.0 17.0 Wnt receptor signaling pathway 0.007 0.059 0.459 5.0 -9999.0 0.0 5.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.086 -9999.0 0.0 -0.618 3.0 3.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.031 0.062 -9999.0 0.0 -0.705 1.0 1.0 EFNA1 0.0 0.09 -9999.0 0.0 -0.682 6.0 6.0 LPP 0.03 0.069 -9999.0 0.0 -0.64 2.0 2.0 Ephrin A1/EPHA2 -0.025 0.1 -9999.0 0.0 -0.71 3.0 3.0 SEC6/SEC8 -0.007 0.052 -9999.0 0.0 -0.648 1.0 1.0 MGAT3 -0.007 0.115 -9999.0 0.0 -0.73 1.0 1.0 HGF/MET -0.077 0.153 -9999.0 0.0 -0.623 8.0 8.0 HGF -0.035 0.173 -9999.0 0.0 -0.657 25.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.051 -9999.0 0.0 -0.608 1.0 1.0 actin cable formation 0.051 0.07 -9999.0 0.0 -0.388 2.0 2.0 KIAA1543 0.018 0.115 -9999.0 0.0 -0.774 5.0 5.0 KIFC3 0.021 0.076 -9999.0 0.0 -0.73 1.0 1.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.01 0.03 -9999.0 0.0 -0.546 1.0 1.0 ACTN1 0.025 0.07 -9999.0 0.0 -0.682 2.0 2.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.007 0.059 -9999.0 0.0 -0.459 5.0 5.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.027 0.06 -9999.0 0.0 -0.73 1.0 1.0 PIP5K1C 0.027 0.06 -9999.0 0.0 -0.73 1.0 1.0 LIMA1 0.009 0.042 -9999.0 0.0 -0.546 2.0 2.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.034 0.088 -9999.0 0.0 -0.52 3.0 3.0 adherens junction assembly 0.025 0.133 -9999.0 0.0 -0.783 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.033 0.109 -9999.0 0.0 -0.633 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.022 -9999.0 0.0 -0.39 1.0 1.0 MET -0.09 0.241 -9999.0 0.0 -0.652 54.0 54.0 PLEKHA7 0.021 0.076 -9999.0 0.0 -0.73 1.0 1.0 mol:GTP -0.022 0.089 -9999.0 0.0 -0.407 16.0 16.0 establishment of epithelial cell apical/basal polarity 0.048 0.057 -9999.0 0.0 -0.615 1.0 1.0 cortical actin cytoskeleton stabilization 0.021 0.051 -9999.0 0.0 -0.601 1.0 1.0 regulation of cell-cell adhesion 0.031 0.06 -9999.0 0.0 -0.679 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.051 -9999.0 0.0 -0.608 1.0 1.0