E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.03 0.139 -9999.0 0.0 -0.395 15.0 15.0 KLHL20 -0.01 0.111 0.213 2.0 -0.302 10.0 12.0 CYFIP2 0.026 0.047 -9999.0 0.0 -0.509 1.0 1.0 Rac1/GDP -0.004 0.106 0.248 1.0 -0.279 7.0 8.0 ENAH -0.03 0.144 -9999.0 0.0 -0.394 17.0 17.0 AP1M1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.062 -9999.0 0.0 -0.509 2.0 2.0 CTNNB1 0.03 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.01 0.078 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.033 0.06 -9999.0 0.0 -0.187 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.084 -9999.0 0.0 -0.289 7.0 7.0 RAPGEF1 -0.021 0.131 0.237 1.0 -0.361 14.0 15.0 CTNND1 0.017 0.096 -9999.0 0.0 -0.509 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.025 0.151 -9999.0 0.0 -0.41 16.0 16.0 CRK -0.017 0.136 -9999.0 0.0 -0.381 15.0 15.0 E-cadherin/gamma catenin/alpha catenin 0.019 0.125 -9999.0 0.0 -0.335 16.0 16.0 alphaE/beta7 Integrin 0.048 0.013 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.047 -9999.0 0.0 -0.509 1.0 1.0 Rap1/GTP/I-afadin 0.055 0.044 -9999.0 0.0 -0.288 2.0 2.0 DLG1 -0.019 0.112 -9999.0 0.0 -0.368 11.0 11.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.044 -9999.0 0.0 -0.254 2.0 2.0 MLLT4 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.057 0.045 -9999.0 0.0 -0.289 2.0 2.0 PI3K -0.011 0.058 -9999.0 0.0 -0.334 2.0 2.0 ARF6 0.026 0.062 -9999.0 0.0 -0.509 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.0 0.136 -9999.0 0.0 -0.389 16.0 16.0 TIAM1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.041 0.097 -9999.0 0.0 -0.273 12.0 12.0 AKT1 0.006 0.057 0.147 2.0 -0.213 4.0 6.0 PIK3R1 0.006 0.099 -9999.0 0.0 -0.509 5.0 5.0 CDH1 0.007 0.113 -9999.0 0.0 -0.509 7.0 7.0 RhoA/GDP 0.003 0.104 0.249 1.0 -0.279 6.0 7.0 actin cytoskeleton organization -0.004 0.082 0.178 2.0 -0.213 10.0 12.0 CDC42/GDP -0.0 0.107 0.249 1.0 -0.279 7.0 8.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.102 -9999.0 0.0 -0.268 20.0 20.0 ITGB7 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.044 0.104 -9999.0 0.0 -0.29 12.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.036 0.072 -9999.0 0.0 -0.269 7.0 7.0 mol:GDP -0.018 0.112 0.249 1.0 -0.32 7.0 8.0 CDC42/GTP/IQGAP1 0.045 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP -0.002 0.134 -9999.0 0.0 -0.509 10.0 10.0 p120 catenin/RhoA/GDP 0.005 0.114 0.257 1.0 -0.289 5.0 6.0 RAC1/GTP/IQGAP1 0.044 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.044 0.037 -9999.0 0.0 -0.371 1.0 1.0 RHOA 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.008 0.077 0.165 1.0 -0.228 12.0 13.0 NME1 0.034 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.033 0.145 -9999.0 0.0 -0.401 16.0 16.0 regulation of cell-cell adhesion -0.002 0.062 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.047 -9999.0 0.0 -0.14 6.0 6.0 Rap1/GTP 0.009 0.087 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.046 0.123 -9999.0 0.0 -0.29 16.0 16.0 CCND1 -0.012 0.095 0.188 1.0 -0.287 12.0 13.0 VAV2 -0.049 0.233 -9999.0 0.0 -0.583 19.0 19.0 RAP1/GDP 0.012 0.096 0.266 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.031 0.141 -9999.0 0.0 -0.389 16.0 16.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.046 -9999.0 0.0 -0.509 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.025 0.111 -9999.0 0.0 -0.283 15.0 15.0 E-cadherin/beta catenin -0.005 0.083 -9999.0 0.0 -0.35 8.0 8.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.033 0.144 -9999.0 0.0 -0.401 16.0 16.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 Rac1/GTP -0.067 0.157 -9999.0 0.0 -0.485 13.0 13.0 E-cadherin/beta catenin/alpha catenin 0.041 0.083 -9999.0 0.0 -0.315 7.0 7.0 ITGAE 0.033 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.026 0.154 -9999.0 0.0 -0.418 16.0 16.0