Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.137 0.275 -9999.0 0.0 -0.566 42.0 42.0 IHH -0.014 0.09 -9999.0 0.0 -0.536 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.042 0.142 -9999.0 0.0 -0.325 28.0 28.0 LRPAP1 0.031 0.011 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.042 0.141 0.323 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.116 0.237 -9999.0 0.0 -0.602 19.0 19.0 SMO -0.131 0.24 -9999.0 0.0 -0.618 20.0 20.0 AKT1 -0.073 0.219 -9999.0 0.0 -0.722 12.0 12.0 ARRB2 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.023 0.027 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.236 -9999.0 0.0 -0.606 20.0 20.0 STIL -0.077 0.158 -9999.0 0.0 -0.459 11.0 11.0 DHH N/PTCH2 0.049 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.05 0.163 -9999.0 0.0 -0.352 15.0 15.0 PIK3CA 0.009 0.062 -9999.0 0.0 -0.509 2.0 2.0 DHH 0.034 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.251 0.449 -9999.0 0.0 -0.957 43.0 43.0 determination of left/right symmetry -0.129 0.236 -9999.0 0.0 -0.606 20.0 20.0 PIK3R1 0.006 0.099 -9999.0 0.0 -0.509 5.0 5.0 skeletal system development -0.247 0.443 -9999.0 0.0 -0.943 43.0 43.0 IHH N/Hhip -0.054 0.157 -9999.0 0.0 -0.422 21.0 21.0 DHH N/Hhip -0.023 0.137 -9999.0 0.0 -0.371 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.236 -9999.0 0.0 -0.606 20.0 20.0 pancreas development -0.057 0.179 -9999.0 0.0 -0.508 20.0 20.0 HHAT -0.005 0.14 -9999.0 0.0 -0.509 11.0 11.0 PI3K 0.004 0.076 -9999.0 0.0 -0.371 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.051 0.185 -9999.0 0.0 -0.509 21.0 21.0 somite specification -0.129 0.236 -9999.0 0.0 -0.606 20.0 20.0 SHH Np/Cholesterol/PTCH1 -0.069 0.164 -9999.0 0.0 -0.456 11.0 11.0 SHH Np/Cholesterol/PTCH2 0.008 0.086 -9999.0 0.0 -0.288 12.0 12.0 SHH Np/Cholesterol/Megalin 0.002 0.092 -9999.0 0.0 -0.294 13.0 13.0 SHH -0.013 0.104 -9999.0 0.0 -0.371 12.0 12.0 catabolic process -0.069 0.173 -9999.0 0.0 -0.339 42.0 42.0 SMO/Vitamin D3 -0.103 0.205 -9999.0 0.0 -0.53 18.0 18.0 SHH Np/Cholesterol/Hhip -0.044 0.128 -9999.0 0.0 -0.297 29.0 29.0 LRP2 0.022 0.052 -9999.0 0.0 -0.509 1.0 1.0 receptor-mediated endocytosis -0.103 0.196 -9999.0 0.0 -0.508 18.0 18.0 SHH Np/Cholesterol/BOC -0.0 0.086 -9999.0 0.0 -0.288 12.0 12.0 SHH Np/Cholesterol/CDO 0.006 0.087 -9999.0 0.0 -0.29 12.0 12.0 mesenchymal cell differentiation 0.044 0.127 0.296 29.0 -9999.0 0.0 29.0 mol:Vitamin D3 -0.069 0.164 -9999.0 0.0 -0.457 11.0 11.0 IHH N/PTCH2 0.016 0.062 -9999.0 0.0 -0.325 1.0 1.0 CDON 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.062 0.18 -9999.0 0.0 -0.341 42.0 42.0 Megalin/LRPAP1 0.035 0.045 -9999.0 0.0 -0.371 1.0 1.0 PTCH2 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.004 0.082 -9999.0 0.0 -0.285 12.0 12.0 PTCH1 -0.069 0.173 -9999.0 0.0 -0.34 42.0 42.0 HHIP -0.057 0.179 -9999.0 0.0 -0.509 20.0 20.0