Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.214 0.34 -9999.0 0.0 -0.655 66.0 66.0 IHH -0.084 0.193 -9999.0 0.0 -0.67 19.0 19.0 SHH Np/Cholesterol/GAS1 -0.109 0.211 -9999.0 0.0 -0.411 66.0 66.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.209 0.408 66.0 -9999.0 0.0 66.0 SMO/beta Arrestin2 -0.163 0.278 -9999.0 0.0 -0.746 28.0 28.0 SMO -0.179 0.294 -9999.0 0.0 -0.74 34.0 34.0 AKT1 -0.06 0.124 -9999.0 0.0 -0.444 4.0 4.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.032 0.162 -9999.0 0.0 -0.629 15.0 15.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.175 0.287 -9999.0 0.0 -0.722 34.0 34.0 STIL -0.178 0.251 -9999.0 0.0 -0.626 37.0 37.0 DHH N/PTCH2 -0.022 0.142 -9999.0 0.0 -0.517 16.0 16.0 DHH N/PTCH1 -0.127 0.225 -9999.0 0.0 -0.592 27.0 27.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.004 0.1 -9999.0 0.0 -0.661 5.0 5.0 PTHLH -0.328 0.502 -9999.0 0.0 -1.116 55.0 55.0 determination of left/right symmetry -0.175 0.287 -9999.0 0.0 -0.722 34.0 34.0 PIK3R1 0.006 0.062 -9999.0 0.0 -0.637 2.0 2.0 skeletal system development -0.322 0.491 -9999.0 0.0 -1.094 55.0 55.0 IHH N/Hhip -0.178 0.268 -9999.0 0.0 -0.559 70.0 70.0 DHH N/Hhip -0.128 0.23 -9999.0 0.0 -0.481 64.0 64.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.175 0.287 -9999.0 0.0 -0.722 34.0 34.0 pancreas development -0.167 0.29 -9999.0 0.0 -0.634 61.0 61.0 HHAT -0.019 0.144 -9999.0 0.0 -0.677 10.0 10.0 PI3K 0.013 0.046 -9999.0 0.0 -0.468 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.034 0.169 -9999.0 0.0 -0.656 15.0 15.0 somite specification -0.175 0.287 -9999.0 0.0 -0.722 34.0 34.0 SHH Np/Cholesterol/PTCH1 -0.192 0.26 -9999.0 0.0 -0.634 41.0 41.0 SHH Np/Cholesterol/PTCH2 -0.104 0.191 -9999.0 0.0 -0.379 69.0 69.0 SHH Np/Cholesterol/Megalin -0.189 0.253 -9999.0 0.0 -0.44 100.0 100.0 SHH -0.113 0.222 -9999.0 0.0 -0.475 59.0 59.0 catabolic process -0.139 0.238 -9999.0 0.0 -0.61 29.0 29.0 SMO/Vitamin D3 -0.206 0.289 -9999.0 0.0 -0.726 38.0 38.0 SHH Np/Cholesterol/Hhip -0.187 0.234 -9999.0 0.0 -0.41 106.0 106.0 LRP2 -0.172 0.295 -9999.0 0.0 -0.642 62.0 62.0 receptor-mediated endocytosis -0.259 0.307 -9999.0 0.0 -0.713 52.0 52.0 SHH Np/Cholesterol/BOC -0.108 0.195 -9999.0 0.0 -0.379 71.0 71.0 SHH Np/Cholesterol/CDO -0.106 0.193 -9999.0 0.0 -0.38 70.0 70.0 mesenchymal cell differentiation 0.185 0.232 0.407 106.0 -9999.0 0.0 106.0 mol:Vitamin D3 -0.191 0.262 -9999.0 0.0 -0.635 41.0 41.0 IHH N/PTCH2 -0.067 0.171 -9999.0 0.0 -0.513 24.0 24.0 CDON -0.029 0.157 -9999.0 0.0 -0.631 14.0 14.0 IHH N/PTCH1 -0.14 0.24 -9999.0 0.0 -0.616 29.0 29.0 Megalin/LRPAP1 -0.12 0.221 -9999.0 0.0 -0.473 62.0 62.0 PTCH2 -0.025 0.154 -9999.0 0.0 -0.664 12.0 12.0 SHH Np/Cholesterol -0.099 0.169 -9999.0 0.0 -0.374 59.0 59.0 PTCH1 -0.139 0.239 -9999.0 0.0 -0.613 29.0 29.0 HHIP -0.168 0.29 -9999.0 0.0 -0.635 61.0 61.0