Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	55.0	443.0	8.0	-0.217	0.109	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by the Hedgehog family	38.0	1987.0	52.0	-0.328	0.185	1000.0	-1000.0	-0.073	-1000.0
Ephrin A  reverse signaling	36.0	254.0	7.0	-0.118	0.0	1000.0	-1000.0	-0.038	-1000.0
IL23-mediated signaling events	34.0	2048.0	60.0	-0.649	0.012	1000.0	-1000.0	-0.214	-1000.0
Wnt signaling	30.0	210.0	7.0	-0.176	0.006	1000.0	-1000.0	-0.041	-1000.0
IL4-mediated signaling events	27.0	2542.0	91.0	-0.681	0.581	1000.0	-1000.0	-0.183	-1000.0
TCGA08_p53	26.0	182.0	7.0	-0.169	0.099	1000.0	-1000.0	-0.013	-1000.0
LPA4-mediated signaling events	23.0	287.0	12.0	-0.148	0.015	1000.0	-1000.0	-0.033	-1000.0
HIF-1-alpha transcription factor network	23.0	1801.0	76.0	-0.427	0.019	1000.0	-1000.0	-0.233	-1000.0
p75(NTR)-mediated signaling	23.0	2993.0	125.0	-0.261	0.033	1000.0	-1000.0	-0.13	-1000.0
Glypican 2 network	23.0	94.0	4.0	-0.063	-0.053	1000.0	-1000.0	-0.028	-1000.0
FOXA2 and FOXA3 transcription factor networks	22.0	1048.0	46.0	-0.329	0.041	1000.0	-1000.0	-0.142	-1000.0
Noncanonical Wnt signaling pathway	21.0	568.0	26.0	-0.176	0.012	1000.0	-1000.0	-0.074	-1000.0
Glypican 1 network	21.0	1044.0	48.0	-0.232	0.041	1000.0	-1000.0	-0.064	-1000.0
Signaling mediated by p38-alpha and p38-beta	21.0	931.0	44.0	-0.316	0.012	1000.0	-1000.0	-0.061	-1000.0
Glucocorticoid receptor regulatory network	20.0	2317.0	114.0	-0.577	0.282	1000.0	-1000.0	-0.09	-1000.0
Syndecan-1-mediated signaling events	18.0	645.0	34.0	-0.156	0.012	1000.0	-1000.0	-0.069	-1000.0
amb2 Integrin signaling	17.0	1432.0	82.0	-0.255	0.014	1000.0	-1000.0	-0.103	-1000.0
BMP receptor signaling	16.0	1313.0	81.0	-0.199	0.03	1000.0	-1000.0	-0.119	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	16.0	2007.0	120.0	-0.298	0.182	1000.0	-1000.0	-0.098	-1000.0
IL12-mediated signaling events	15.0	1375.0	87.0	-0.345	0.09	1000.0	-1000.0	-0.162	-1000.0
Effects of Botulinum toxin	15.0	399.0	26.0	-0.124	0.012	1000.0	-1000.0	-0.077	-1000.0
BCR signaling pathway	15.0	1519.0	99.0	-0.208	0.021	1000.0	-1000.0	-0.112	-1000.0
EGFR-dependent Endothelin signaling events	15.0	335.0	21.0	-0.14	0.018	1000.0	-1000.0	-0.089	-1000.0
Visual signal transduction: Rods	15.0	828.0	52.0	-0.207	0.012	1000.0	-1000.0	-0.097	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	494.0	34.0	-0.064	0.012	1000.0	-1000.0	-0.057	-1000.0
Visual signal transduction: Cones	14.0	553.0	38.0	-0.082	0.012	1000.0	-1000.0	-0.051	-1000.0
Syndecan-2-mediated signaling events	14.0	969.0	69.0	-0.232	0.025	1000.0	-1000.0	-0.063	-1000.0
Signaling events regulated by Ret tyrosine kinase	14.0	1178.0	82.0	-0.154	0.012	1000.0	-1000.0	-0.108	-1000.0
Endothelins	14.0	1378.0	96.0	-0.196	0.019	1000.0	-1000.0	-0.11	-1000.0
Syndecan-4-mediated signaling events	14.0	951.0	67.0	-0.232	0.013	1000.0	-1000.0	-0.094	-1000.0
Reelin signaling pathway	13.0	766.0	56.0	-0.188	0.019	1000.0	-1000.0	-0.097	-1000.0
TCR signaling in naïve CD8+ T cells	13.0	1300.0	93.0	-0.178	0.093	1000.0	-1000.0	-0.109	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	838.0	68.0	-0.258	0.045	1000.0	-1000.0	-0.177	-1000.0
Coregulation of Androgen receptor activity	11.0	837.0	76.0	-0.224	0.024	1000.0	-1000.0	-0.052	-1000.0
Thromboxane A2 receptor signaling	11.0	1181.0	105.0	-0.123	0.026	1000.0	-1000.0	-0.084	-1000.0
Arf6 signaling events	11.0	706.0	62.0	-0.14	0.012	1000.0	-1000.0	-0.077	-1000.0
Signaling events mediated by PTP1B	11.0	857.0	76.0	-0.191	0.022	1000.0	-1000.0	-0.097	-1000.0
IL1-mediated signaling events	11.0	693.0	62.0	-0.229	0.056	1000.0	-1000.0	-0.121	-1000.0
Syndecan-3-mediated signaling events	11.0	405.0	35.0	-0.162	0.033	1000.0	-1000.0	-0.068	-1000.0
Canonical Wnt signaling pathway	11.0	602.0	51.0	-0.262	0.085	1000.0	-1000.0	-0.087	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	366.0	31.0	-0.182	0.012	1000.0	-1000.0	-0.107	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	623.0	61.0	-0.262	0.03	1000.0	-1000.0	-0.103	-1000.0
EPHB forward signaling	10.0	933.0	85.0	-0.149	0.113	1000.0	-1000.0	-0.105	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	10.0	340.0	33.0	-0.224	0.032	1000.0	-1000.0	-0.076	-1000.0
ErbB4 signaling events	9.0	658.0	69.0	-0.19	0.05	1000.0	-1000.0	-0.116	-1000.0
Fc-epsilon receptor I signaling in mast cells	9.0	917.0	97.0	-0.123	0.027	1000.0	-1000.0	-0.104	-1000.0
S1P5 pathway	9.0	157.0	17.0	-0.073	0.076	1000.0	-1000.0	-0.052	-1000.0
Ephrin B reverse signaling	9.0	473.0	48.0	-0.15	0.092	1000.0	-1000.0	-0.078	-1000.0
LPA receptor mediated events	9.0	952.0	102.0	-0.123	0.033	1000.0	-1000.0	-0.104	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1098.0	136.0	-0.203	0.132	1000.0	-1000.0	-0.092	-1000.0
Nectin adhesion pathway	8.0	518.0	63.0	-0.101	0.022	1000.0	-1000.0	-0.097	-1000.0
Integrins in angiogenesis	8.0	723.0	84.0	-0.105	0.024	1000.0	-1000.0	-0.115	-1000.0
IL27-mediated signaling events	8.0	418.0	51.0	-0.108	0.037	1000.0	-1000.0	-0.109	-1000.0
Plasma membrane estrogen receptor signaling	8.0	760.0	86.0	-0.085	0.031	1000.0	-1000.0	-0.111	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	8.0	687.0	78.0	-0.072	0.034	1000.0	-1000.0	-0.092	-1000.0
Caspase cascade in apoptosis	7.0	542.0	74.0	-0.083	0.019	1000.0	-1000.0	-0.054	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	7.0	395.0	54.0	-0.136	0.024	1000.0	-1000.0	-0.12	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	459.0	65.0	-0.203	0.041	1000.0	-1000.0	-0.085	-1000.0
TRAIL signaling pathway	7.0	339.0	48.0	-0.039	0.022	1000.0	-1000.0	-0.081	-1000.0
Nongenotropic Androgen signaling	7.0	415.0	52.0	-0.109	0.012	1000.0	-1000.0	-0.073	-1000.0
Regulation of Androgen receptor activity	7.0	511.0	70.0	-0.332	0.025	1000.0	-1000.0	-0.095	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	171.0	28.0	-0.073	0.023	1000.0	-1000.0	-0.047	-1000.0
Signaling events mediated by HDAC Class III	6.0	275.0	40.0	-0.087	0.07	1000.0	-1000.0	-0.052	-1000.0
S1P1 pathway	6.0	247.0	36.0	-0.101	0.012	1000.0	-1000.0	-0.072	-1000.0
FAS signaling pathway (CD95)	6.0	299.0	47.0	-0.075	0.018	1000.0	-1000.0	-0.071	-1000.0
IL6-mediated signaling events	6.0	453.0	75.0	-0.319	0.043	1000.0	-1000.0	-0.117	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	535.0	88.0	-0.125	0.05	1000.0	-1000.0	-0.133	-1000.0
S1P4 pathway	6.0	154.0	25.0	-0.073	0.019	1000.0	-1000.0	-0.067	-1000.0
ErbB2/ErbB3 signaling events	5.0	335.0	65.0	-0.107	0.021	1000.0	-1000.0	-0.086	-1000.0
Osteopontin-mediated events	5.0	215.0	38.0	-0.078	0.014	1000.0	-1000.0	-0.129	-1000.0
JNK signaling in the CD4+ TCR pathway	5.0	89.0	17.0	-0.013	0.018	1000.0	-1000.0	-0.055	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	5.0	298.0	52.0	-0.077	0.018	1000.0	-1000.0	-0.06	-1000.0
IL2 signaling events mediated by PI3K	5.0	322.0	58.0	-0.092	0.024	1000.0	-1000.0	-0.11	-1000.0
IL2 signaling events mediated by STAT5	5.0	129.0	22.0	-0.057	0.024	1000.0	-1000.0	-0.084	-1000.0
Regulation of Telomerase	5.0	584.0	102.0	-0.149	0.039	1000.0	-1000.0	-0.134	-1000.0
IGF1 pathway	5.0	333.0	57.0	-0.048	0.024	1000.0	-1000.0	-0.108	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.021	-1000.0
FOXM1 transcription factor network	5.0	290.0	51.0	-0.231	0.141	1000.0	-1000.0	-0.232	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	98.0	17.0	-0.023	0.019	1000.0	-1000.0	-0.059	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	21.0	5.0	-0.007	0.011	1000.0	-1000.0	-0.03	-1000.0
Cellular roles of Anthrax toxin	4.0	161.0	39.0	-0.054	0.017	1000.0	-1000.0	-0.029	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	398.0	85.0	-0.056	0.022	1000.0	-1000.0	-0.096	-1000.0
PDGFR-alpha signaling pathway	4.0	214.0	44.0	-0.036	0.021	1000.0	-1000.0	-0.075	-1000.0
Ceramide signaling pathway	4.0	307.0	76.0	-0.123	0.039	1000.0	-1000.0	-0.062	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	154.0	37.0	-0.041	0.025	1000.0	-1000.0	-0.066	-1000.0
Retinoic acid receptors-mediated signaling	4.0	237.0	58.0	-0.063	0.024	1000.0	-1000.0	-0.09	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	188.0	45.0	-0.054	0.029	1000.0	-1000.0	-0.118	-1000.0
Aurora A signaling	3.0	197.0	60.0	-0.112	0.03	1000.0	-1000.0	-0.065	-1000.0
HIF-2-alpha transcription factor network	3.0	160.0	43.0	-0.059	0.041	1000.0	-1000.0	-0.123	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	58.0	15.0	-0.017	0.022	1000.0	-1000.0	-0.043	-1000.0
Regulation of p38-alpha and p38-beta	3.0	189.0	54.0	-0.131	0.029	1000.0	-1000.0	-0.081	-1000.0
TCGA08_rtk_signaling	3.0	88.0	26.0	-0.069	0.038	1000.0	-1000.0	-0.029	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	260.0	74.0	-0.132	0.058	1000.0	-1000.0	-0.116	-1000.0
Insulin Pathway	3.0	291.0	74.0	-0.213	0.032	1000.0	-1000.0	-0.1	-1000.0
S1P3 pathway	3.0	143.0	42.0	-0.058	0.023	1000.0	-1000.0	-0.056	-1000.0
Rapid glucocorticoid signaling	3.0	73.0	20.0	-0.038	0.014	1000.0	-1000.0	-0.032	-1000.0
PDGFR-beta signaling pathway	3.0	354.0	97.0	-0.108	0.034	1000.0	-1000.0	-0.107	-1000.0
Signaling events mediated by PRL	3.0	112.0	34.0	-0.062	0.025	1000.0	-1000.0	-0.041	-1000.0
p38 MAPK signaling pathway	3.0	163.0	44.0	-0.116	0.023	1000.0	-1000.0	-0.08	-1000.0
Signaling events mediated by HDAC Class II	2.0	155.0	75.0	-0.074	0.03	1000.0	-1000.0	-0.061	-1000.0
BARD1 signaling events	2.0	121.0	57.0	-0.019	0.05	1000.0	-1000.0	-0.078	-1000.0
PLK2 and PLK4 events	2.0	8.0	3.0	0.004	0.012	1000.0	-1000.0	-0.034	-1000.0
Circadian rhythm pathway	2.0	52.0	22.0	-0.029	0.039	1000.0	-1000.0	-0.067	-1000.0
Arf6 downstream pathway	2.0	100.0	43.0	-0.015	0.021	1000.0	-1000.0	-0.053	-1000.0
Aurora C signaling	2.0	14.0	7.0	-0.006	0.009	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	2.0	186.0	68.0	-0.115	0.031	1000.0	-1000.0	-0.119	-1000.0
ceramide signaling pathway	2.0	106.0	49.0	-0.054	0.031	1000.0	-1000.0	-0.069	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	169.0	83.0	-0.039	0.058	1000.0	-1000.0	-0.093	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	298.0	125.0	-0.032	0.053	1000.0	-1000.0	-0.122	-1000.0
Class I PI3K signaling events	2.0	217.0	73.0	-0.131	0.031	1000.0	-1000.0	-0.088	-1000.0
Aurora B signaling	2.0	181.0	67.0	-0.091	0.028	1000.0	-1000.0	-0.086	-1000.0
Canonical NF-kappaB pathway	1.0	76.0	39.0	-0.054	0.066	1000.0	-1000.0	-0.113	-1000.0
EPO signaling pathway	1.0	107.0	55.0	-0.029	0.033	1000.0	-1000.0	-0.126	-1000.0
mTOR signaling pathway	1.0	63.0	53.0	-0.008	0.026	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by HDAC Class I	1.0	126.0	104.0	-0.054	0.048	1000.0	-1000.0	-0.082	-1000.0
FoxO family signaling	1.0	84.0	64.0	-0.059	0.12	1000.0	-1000.0	-0.086	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	64.0	36.0	-0.041	0.031	1000.0	-1000.0	-0.092	-1000.0
Atypical NF-kappaB pathway	1.0	51.0	31.0	-0.022	0.031	1000.0	-1000.0	-0.059	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	100.0	76.0	-0.04	0.049	1000.0	-1000.0	-0.1	-1000.0
Arf6 trafficking events	1.0	90.0	71.0	-0.029	0.039	1000.0	-1000.0	-0.101	-1000.0
VEGFR1 specific signals	1.0	78.0	56.0	-0.02	0.038	1000.0	-1000.0	-0.091	-1000.0
E-cadherin signaling in keratinocytes	1.0	65.0	43.0	-0.069	0.04	1000.0	-1000.0	-0.077	-1000.0
Alternative NF-kappaB pathway	1.0	24.0	13.0	-0.011	0.024	1000.0	-1000.0	-0.038	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	3.0	23.0	0.009	0.041	1000.0	-1000.0	-0.073	-1000.0
PLK1 signaling events	0.0	80.0	85.0	-0.009	0.032	1000.0	-1000.0	-0.059	-1000.0
Insulin-mediated glucose transport	0.0	27.0	32.0	-0.013	0.034	1000.0	-1000.0	-0.084	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	39.0	68.0	-0.034	0.047	1000.0	-1000.0	-0.072	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	-0.0	0.03	1000.0	-1000.0	-0.071	-1000.0
E-cadherin signaling events	0.0	2.0	5.0	0.009	0.022	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	0.0	20.0	54.0	-0.003	0.025	1000.0	-1000.0	-0.042	-1000.0
Total	1161	65913	7203	-17.1260207413	-994.514555422	131000	-131000	-11.2411789897	-131000