E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.013 0.103 -9999.0 0.0 -0.347 7.0 7.0 KLHL20 0.003 0.086 0.194 3.0 -0.261 8.0 11.0 CYFIP2 0.021 0.054 -9999.0 0.0 -0.399 3.0 3.0 Rac1/GDP 0.013 0.083 0.251 2.0 -9999.0 0.0 2.0 ENAH -0.011 0.105 -9999.0 0.0 -0.338 13.0 13.0 AP1M1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.02 0.042 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.022 0.046 -9999.0 0.0 -0.176 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.052 0.065 -9999.0 0.0 -0.297 6.0 6.0 RAPGEF1 -0.004 0.096 0.229 1.0 -9999.0 0.0 1.0 CTNND1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.111 -9999.0 0.0 -0.342 15.0 15.0 CRK -0.004 0.098 -9999.0 0.0 -0.335 4.0 4.0 E-cadherin/gamma catenin/alpha catenin 0.051 0.031 -9999.0 0.0 -0.323 1.0 1.0 alphaE/beta7 Integrin 0.029 0.069 -9999.0 0.0 -0.376 6.0 6.0 IQGAP1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.002 0.075 -9999.0 0.0 -0.348 5.0 5.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.045 0.047 -9999.0 0.0 -0.294 3.0 3.0 PI3K 0.001 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.038 0.03 -9999.0 0.0 -0.376 1.0 1.0 TIAM1 0.018 0.067 -9999.0 0.0 -0.342 6.0 6.0 E-cadherin(dimer)/Ca2+ 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.005 0.033 0.135 1.0 -9999.0 0.0 1.0 PIK3R1 0.023 0.04 -9999.0 0.0 -0.342 2.0 2.0 CDH1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.02 0.078 0.254 2.0 -9999.0 0.0 2.0 actin cytoskeleton organization 0.004 0.065 0.141 5.0 -0.193 7.0 12.0 CDC42/GDP 0.017 0.082 0.254 2.0 -9999.0 0.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.019 -9999.0 0.0 -0.248 1.0 1.0 ITGB7 0.014 0.088 -9999.0 0.0 -0.514 6.0 6.0 RAC1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.064 0.026 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.045 0.018 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.001 0.088 0.258 2.0 -9999.0 0.0 2.0 CDC42/GTP/IQGAP1 0.037 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.037 -9999.0 0.0 -0.514 1.0 1.0 p120 catenin/RhoA/GDP 0.026 0.079 0.259 2.0 -9999.0 0.0 2.0 RAC1/GTP/IQGAP1 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.041 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.001 0.062 0.122 3.0 -0.218 11.0 14.0 NME1 0.028 0.014 -9999.0 0.0 -0.17 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.012 0.105 -9999.0 0.0 -0.338 13.0 13.0 regulation of cell-cell adhesion 0.008 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.004 0.034 -9999.0 0.0 -0.134 2.0 2.0 Rap1/GTP 0.02 0.048 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.062 0.07 -9999.0 0.0 -0.283 7.0 7.0 CCND1 -0.002 0.076 0.153 2.0 -0.273 11.0 13.0 VAV2 -0.011 0.183 -9999.0 0.0 -0.633 12.0 12.0 RAP1/GDP 0.024 0.064 0.246 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.011 0.103 -9999.0 0.0 -0.329 13.0 13.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.043 0.063 -9999.0 0.0 -0.275 7.0 7.0 E-cadherin/beta catenin 0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.013 0.106 -9999.0 0.0 -0.347 7.0 7.0 PIK3CA 0.014 0.014 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.039 0.113 -9999.0 0.0 -0.405 11.0 11.0 E-cadherin/beta catenin/alpha catenin 0.051 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.004 0.113 -9999.0 0.0 -0.348 15.0 15.0