Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.145 0.256 -9999.0 0.0 -0.57 53.0 53.0 IHH -0.042 0.122 -9999.0 0.0 -0.397 13.0 13.0 SHH Np/Cholesterol/GAS1 -0.045 0.13 -9999.0 0.0 -0.328 34.0 34.0 LRPAP1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.045 0.13 0.326 34.0 -9999.0 0.0 34.0 SMO/beta Arrestin2 -0.118 0.234 -9999.0 0.0 -0.638 24.0 24.0 SMO -0.13 0.241 -9999.0 0.0 -0.604 31.0 31.0 AKT1 -0.063 0.156 -9999.0 0.0 -0.621 10.0 10.0 ARRB2 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.093 -9999.0 0.0 -0.514 6.0 6.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.236 -9999.0 0.0 -0.592 31.0 31.0 STIL -0.115 0.171 -9999.0 0.0 -0.429 34.0 34.0 DHH N/PTCH2 0.015 0.101 -9999.0 0.0 -0.404 11.0 11.0 DHH N/PTCH1 -0.077 0.171 -9999.0 0.0 -0.334 57.0 57.0 PIK3CA 0.014 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.065 -9999.0 0.0 -0.428 4.0 4.0 PTHLH -0.237 0.414 -9999.0 0.0 -0.938 54.0 54.0 determination of left/right symmetry -0.129 0.236 -9999.0 0.0 -0.592 31.0 31.0 PIK3R1 0.023 0.04 -9999.0 0.0 -0.342 2.0 2.0 skeletal system development -0.234 0.408 -9999.0 0.0 -0.924 54.0 54.0 IHH N/Hhip -0.079 0.164 -9999.0 0.0 -0.359 46.0 46.0 DHH N/Hhip -0.043 0.149 -9999.0 0.0 -0.381 31.0 31.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.236 -9999.0 0.0 -0.592 31.0 31.0 pancreas development -0.071 0.182 -9999.0 0.0 -0.333 59.0 59.0 HHAT 0.006 0.107 -9999.0 0.0 -0.514 9.0 9.0 PI3K 0.017 0.034 -9999.0 0.0 -0.376 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.002 0.11 -9999.0 0.0 -0.408 13.0 13.0 somite specification -0.129 0.236 -9999.0 0.0 -0.592 31.0 31.0 SHH Np/Cholesterol/PTCH1 -0.114 0.177 -9999.0 0.0 -0.349 66.0 66.0 SHH Np/Cholesterol/PTCH2 -0.045 0.122 -9999.0 0.0 -0.298 37.0 37.0 SHH Np/Cholesterol/Megalin -0.087 0.158 -9999.0 0.0 -0.325 58.0 58.0 SHH -0.056 0.131 -9999.0 0.0 -0.389 26.0 26.0 catabolic process -0.091 0.178 -9999.0 0.0 -0.371 54.0 54.0 SMO/Vitamin D3 -0.134 0.216 -9999.0 0.0 -0.529 35.0 35.0 SHH Np/Cholesterol/Hhip -0.084 0.147 -9999.0 0.0 -0.332 49.0 49.0 LRP2 -0.08 0.197 -9999.0 0.0 -0.362 61.0 61.0 receptor-mediated endocytosis -0.172 0.231 -9999.0 0.0 -0.542 43.0 43.0 SHH Np/Cholesterol/BOC -0.041 0.119 -9999.0 0.0 -0.315 30.0 30.0 SHH Np/Cholesterol/CDO -0.043 0.119 -9999.0 0.0 -0.301 34.0 34.0 mesenchymal cell differentiation 0.084 0.146 0.33 49.0 -9999.0 0.0 49.0 mol:Vitamin D3 -0.113 0.179 -9999.0 0.0 -0.393 46.0 46.0 IHH N/PTCH2 -0.024 0.117 -9999.0 0.0 -0.402 15.0 15.0 CDON 0.006 0.095 -9999.0 0.0 -0.318 14.0 14.0 IHH N/PTCH1 -0.086 0.183 -9999.0 0.0 -0.373 54.0 54.0 Megalin/LRPAP1 -0.045 0.15 -9999.0 0.0 -0.373 34.0 34.0 PTCH2 0.004 0.109 -9999.0 0.0 -0.451 11.0 11.0 SHH Np/Cholesterol -0.037 0.105 -9999.0 0.0 -0.299 27.0 27.0 PTCH1 -0.091 0.179 -9999.0 0.0 -0.372 54.0 54.0 HHIP -0.071 0.182 -9999.0 0.0 -0.333 59.0 59.0