Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.054 0.022 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.021 0.054 -9999.0 0.0 -0.399 3.0 3.0 ENAH 0.004 0.082 0.259 6.0 -0.343 1.0 7.0 EGFR -0.015 0.145 -9999.0 0.0 -0.514 17.0 17.0 EPHA2 0.005 0.104 -9999.0 0.0 -0.514 8.0 8.0 MYO6 -0.01 0.034 -9999.0 0.0 -0.272 1.0 1.0 CTNNB1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.042 -9999.0 0.0 -0.323 2.0 2.0 AQP5 -0.078 0.178 -9999.0 0.0 -0.462 38.0 38.0 CTNND1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.008 0.029 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.059 -9999.0 0.0 -0.268 9.0 9.0 EGF -0.05 0.174 -9999.0 0.0 -0.38 41.0 41.0 NCKAP1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.04 0.133 -9999.0 0.0 -0.443 20.0 20.0 cortical microtubule organization 0.054 0.022 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.009 0.026 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.028 0.05 -9999.0 0.0 -0.463 1.0 1.0 ARF6 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.079 -9999.0 0.0 -0.334 7.0 7.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.003 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.01 0.03 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.043 0.079 -9999.0 0.0 -0.315 7.0 7.0 CDH1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.021 0.135 -9999.0 0.0 -0.305 35.0 35.0 RhoA/GDP 0.054 0.023 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.013 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.008 0.101 -9999.0 0.0 -0.513 8.0 8.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.008 0.102 -9999.0 0.0 -0.514 8.0 8.0 IGF1 0.002 0.107 -9999.0 0.0 -0.342 16.0 16.0 DIAPH1 -0.001 0.172 -9999.0 0.0 -0.582 4.0 4.0 Wnt receptor signaling pathway -0.054 0.022 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.028 0.05 -9999.0 0.0 -0.459 1.0 1.0 CTNNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.013 0.028 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.022 0.052 -9999.0 0.0 -0.514 2.0 2.0 LPP -0.01 0.025 -9999.0 0.0 -0.267 1.0 1.0 Ephrin A1/EPHA2 0.031 0.071 -9999.0 0.0 -0.296 8.0 8.0 SEC6/SEC8 -0.017 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.024 0.06 -9999.0 0.0 -0.272 9.0 9.0 HGF/MET 0.018 0.09 -9999.0 0.0 -0.271 15.0 15.0 HGF -0.013 0.135 -9999.0 0.0 -0.399 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.047 0.104 0.297 12.0 -0.307 1.0 13.0 KIAA1543 -0.011 0.036 -9999.0 0.0 -0.26 2.0 2.0 KIFC3 -0.014 0.038 -9999.0 0.0 -0.272 2.0 2.0 NCK1 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.022 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.01 0.029 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.035 0.017 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.054 0.022 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.009 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.008 0.029 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.011 0.097 0.277 9.0 -0.404 1.0 10.0 adherens junction assembly -0.013 0.084 0.258 1.0 -0.45 4.0 5.0 IGF-1R heterotetramer/IGF1 0.024 0.082 -9999.0 0.0 -0.267 13.0 13.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.015 0.082 -9999.0 0.0 -0.514 5.0 5.0 PLEKHA7 -0.011 0.039 -9999.0 0.0 -0.272 2.0 2.0 mol:GTP 0.039 0.078 -9999.0 0.0 -0.332 7.0 7.0 establishment of epithelial cell apical/basal polarity 0.028 0.091 0.349 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.013 0.027 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.022 0.009 -9999.0 0.0 -9999.0 0.0 0.0