Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling mediated by p38-alpha and p38-beta	38.0	1673.0	44.0	-0.222	0.028	1000.0	-1000.0	-0.034	-1000.0
TCGA08_retinoblastoma	31.0	252.0	8.0	-0.059	0.073	1000.0	-1000.0	-0.005	-1000.0
Signaling events mediated by the Hedgehog family	30.0	1560.0	52.0	-0.237	0.084	1000.0	-1000.0	-0.049	-1000.0
IL23-mediated signaling events	30.0	1846.0	60.0	-0.523	0.028	1000.0	-1000.0	-0.106	-1000.0
Wnt signaling	29.0	206.0	7.0	-0.105	0.024	1000.0	-1000.0	-0.026	-1000.0
IL4-mediated signaling events	26.0	2377.0	91.0	-0.55	0.47	1000.0	-1000.0	-0.136	-1000.0
Glucocorticoid receptor regulatory network	22.0	2561.0	114.0	-0.444	0.212	1000.0	-1000.0	-0.05	-1000.0
HIF-1-alpha transcription factor network	21.0	1650.0	76.0	-0.263	0.039	1000.0	-1000.0	-0.126	-1000.0
Syndecan-1-mediated signaling events	20.0	706.0	34.0	-0.074	0.029	1000.0	-1000.0	-0.038	-1000.0
Noncanonical Wnt signaling pathway	20.0	542.0	26.0	-0.106	0.028	1000.0	-1000.0	-0.052	-1000.0
p75(NTR)-mediated signaling	18.0	2371.0	125.0	-0.113	0.068	1000.0	-1000.0	-0.074	-1000.0
Ephrin A  reverse signaling	17.0	122.0	7.0	-0.042	0.01	1000.0	-1000.0	-0.007	-1000.0
Glypican 1 network	17.0	841.0	48.0	-0.117	0.029	1000.0	-1000.0	-0.038	-1000.0
EGFR-dependent Endothelin signaling events	17.0	361.0	21.0	-0.063	0.041	1000.0	-1000.0	-0.045	-1000.0
BCR signaling pathway	16.0	1647.0	99.0	-0.141	0.043	1000.0	-1000.0	-0.062	-1000.0
Ephrin B reverse signaling	15.0	737.0	48.0	-0.083	0.031	1000.0	-1000.0	-0.034	-1000.0
IL12-mediated signaling events	14.0	1295.0	87.0	-0.264	0.039	1000.0	-1000.0	-0.086	-1000.0
BMP receptor signaling	14.0	1141.0	81.0	-0.1	0.052	1000.0	-1000.0	-0.055	-1000.0
Endothelins	14.0	1355.0	96.0	-0.155	0.043	1000.0	-1000.0	-0.064	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1339.0	93.0	-0.086	0.041	1000.0	-1000.0	-0.058	-1000.0
FOXA2 and FOXA3 transcription factor networks	13.0	613.0	46.0	-0.236	0.055	1000.0	-1000.0	-0.123	-1000.0
EPHB forward signaling	13.0	1116.0	85.0	-0.085	0.066	1000.0	-1000.0	-0.072	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1642.0	120.0	-0.15	0.091	1000.0	-1000.0	-0.049	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1253.0	97.0	-0.062	0.07	1000.0	-1000.0	-0.071	-1000.0
amb2 Integrin signaling	12.0	1029.0	82.0	-0.118	0.036	1000.0	-1000.0	-0.047	-1000.0
TCGA08_p53	12.0	84.0	7.0	-0.03	0.028	1000.0	-1000.0	-0.011	-1000.0
Calcium signaling in the CD4+ TCR pathway	12.0	387.0	31.0	-0.125	0.028	1000.0	-1000.0	-0.053	-1000.0
LPA receptor mediated events	12.0	1294.0	102.0	-0.112	0.036	1000.0	-1000.0	-0.078	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	831.0	68.0	-0.174	0.049	1000.0	-1000.0	-0.111	-1000.0
Signaling events mediated by PTP1B	11.0	898.0	76.0	-0.076	0.038	1000.0	-1000.0	-0.049	-1000.0
S1P5 pathway	11.0	193.0	17.0	-0.048	0.039	1000.0	-1000.0	-0.021	-1000.0
Glypican 2 network	11.0	46.0	4.0	-0.018	0.001	1000.0	-1000.0	0.006	-1000.0
Syndecan-4-mediated signaling events	11.0	768.0	67.0	-0.117	0.037	1000.0	-1000.0	-0.055	-1000.0
Visual signal transduction: Rods	11.0	603.0	52.0	-0.093	0.03	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	10.0	777.0	74.0	-0.069	0.062	1000.0	-1000.0	-0.043	-1000.0
Thromboxane A2 receptor signaling	10.0	1153.0	105.0	-0.058	0.034	1000.0	-1000.0	-0.056	-1000.0
Arf6 signaling events	10.0	647.0	62.0	-0.051	0.04	1000.0	-1000.0	-0.047	-1000.0
Reelin signaling pathway	10.0	579.0	56.0	-0.065	0.062	1000.0	-1000.0	-0.051	-1000.0
Canonical Wnt signaling pathway	10.0	539.0	51.0	-0.119	0.06	1000.0	-1000.0	-0.062	-1000.0
LPA4-mediated signaling events	9.0	110.0	12.0	-0.059	0.004	1000.0	-1000.0	-0.031	-1000.0
ErbB2/ErbB3 signaling events	9.0	629.0	65.0	-0.063	0.041	1000.0	-1000.0	-0.063	-1000.0
Syndecan-2-mediated signaling events	9.0	651.0	69.0	-0.117	0.041	1000.0	-1000.0	-0.039	-1000.0
mTOR signaling pathway	9.0	502.0	53.0	-0.044	0.096	1000.0	-1000.0	-0.042	-1000.0
IL1-mediated signaling events	9.0	565.0	62.0	-0.104	0.052	1000.0	-1000.0	-0.053	-1000.0
Effects of Botulinum toxin	9.0	244.0	26.0	-0.049	0.028	1000.0	-1000.0	-0.021	-1000.0
Plasma membrane estrogen receptor signaling	9.0	791.0	86.0	-0.094	0.046	1000.0	-1000.0	-0.064	-1000.0
Visual signal transduction: Cones	8.0	329.0	38.0	-0.036	0.03	1000.0	-1000.0	-0.014	-1000.0
Osteopontin-mediated events	8.0	334.0	38.0	-0.06	0.032	1000.0	-1000.0	-0.05	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	501.0	61.0	-0.12	0.068	1000.0	-1000.0	-0.056	-1000.0
S1P1 pathway	8.0	292.0	36.0	-0.101	0.028	1000.0	-1000.0	-0.054	-1000.0
FAS signaling pathway (CD95)	8.0	422.0	47.0	-0.051	0.064	1000.0	-1000.0	-0.038	-1000.0
Nongenotropic Androgen signaling	8.0	460.0	52.0	-0.047	0.028	1000.0	-1000.0	-0.042	-1000.0
IL27-mediated signaling events	8.0	434.0	51.0	-0.118	0.045	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	8.0	480.0	57.0	-0.051	0.056	1000.0	-1000.0	-0.049	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	955.0	136.0	-0.292	0.074	1000.0	-1000.0	-0.052	-1000.0
Coregulation of Androgen receptor activity	7.0	570.0	76.0	-0.117	0.052	1000.0	-1000.0	-0.023	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	7.0	610.0	85.0	-0.031	0.057	1000.0	-1000.0	-0.059	-1000.0
Nectin adhesion pathway	7.0	492.0	63.0	-0.036	0.05	1000.0	-1000.0	-0.047	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	597.0	82.0	-0.028	0.029	1000.0	-1000.0	-0.063	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	7.0	382.0	52.0	-0.052	0.036	1000.0	-1000.0	-0.055	-1000.0
Syndecan-3-mediated signaling events	7.0	256.0	35.0	-0.066	0.068	1000.0	-1000.0	-0.036	-1000.0
Integrins in angiogenesis	7.0	619.0	84.0	-0.066	0.061	1000.0	-1000.0	-0.057	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	7.0	238.0	33.0	-0.067	0.071	1000.0	-1000.0	-0.036	-1000.0
S1P4 pathway	7.0	193.0	25.0	-0.047	0.046	1000.0	-1000.0	-0.032	-1000.0
Regulation of Androgen receptor activity	7.0	495.0	70.0	-0.165	0.036	1000.0	-1000.0	-0.061	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	6.0	224.0	34.0	-0.014	0.028	1000.0	-1000.0	-0.029	-1000.0
ErbB4 signaling events	6.0	472.0	69.0	-0.079	0.039	1000.0	-1000.0	-0.045	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	6.0	352.0	54.0	-0.058	0.04	1000.0	-1000.0	-0.052	-1000.0
JNK signaling in the CD4+ TCR pathway	6.0	108.0	17.0	-0.018	0.043	1000.0	-1000.0	-0.039	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	417.0	65.0	-0.124	0.064	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by PI3K	6.0	358.0	58.0	-0.056	0.037	1000.0	-1000.0	-0.053	-1000.0
FOXM1 transcription factor network	6.0	331.0	51.0	-0.032	0.129	1000.0	-1000.0	-0.16	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	6.0	488.0	78.0	-0.045	0.029	1000.0	-1000.0	-0.05	-1000.0
Sphingosine 1-phosphate (S1P) pathway	5.0	152.0	28.0	-0.034	0.044	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	5.0	397.0	68.0	-0.04	0.055	1000.0	-1000.0	-0.06	-1000.0
Ceramide signaling pathway	5.0	425.0	76.0	-0.05	0.072	1000.0	-1000.0	-0.04	-1000.0
HIF-2-alpha transcription factor network	5.0	245.0	43.0	-0.041	0.05	1000.0	-1000.0	-0.071	-1000.0
TCGA08_rtk_signaling	5.0	138.0	26.0	-0.073	0.086	1000.0	-1000.0	-0.017	-1000.0
IL6-mediated signaling events	5.0	438.0	75.0	-0.261	0.054	1000.0	-1000.0	-0.084	-1000.0
IL2 signaling events mediated by STAT5	5.0	116.0	22.0	-0.027	0.029	1000.0	-1000.0	-0.053	-1000.0
Regulation of Telomerase	5.0	511.0	102.0	-0.1	0.07	1000.0	-1000.0	-0.058	-1000.0
Insulin Pathway	5.0	378.0	74.0	-0.07	0.062	1000.0	-1000.0	-0.052	-1000.0
Angiopoietin receptor Tie2-mediated signaling	5.0	525.0	88.0	-0.066	0.037	1000.0	-1000.0	-0.092	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	91.0	17.0	0.0	0.046	1000.0	-1000.0	-0.032	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	21.0	5.0	0.014	0.034	1000.0	-1000.0	0.008	-1000.0
Cellular roles of Anthrax toxin	4.0	178.0	39.0	-0.033	0.032	1000.0	-1000.0	-0.022	-1000.0
PLK1 signaling events	4.0	363.0	85.0	-0.028	0.106	1000.0	-1000.0	-0.027	-1000.0
PDGFR-alpha signaling pathway	4.0	197.0	44.0	-0.025	0.05	1000.0	-1000.0	-0.045	-1000.0
TRAIL signaling pathway	4.0	233.0	48.0	-0.007	0.07	1000.0	-1000.0	-0.037	-1000.0
Retinoic acid receptors-mediated signaling	4.0	236.0	58.0	-0.024	0.053	1000.0	-1000.0	-0.054	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	4.0	188.0	45.0	-0.03	0.061	1000.0	-1000.0	-0.053	-1000.0
Regulation of p38-alpha and p38-beta	4.0	231.0	54.0	-0.057	0.066	1000.0	-1000.0	-0.053	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	353.0	74.0	-0.078	0.059	1000.0	-1000.0	-0.076	-1000.0
Class I PI3K signaling events	4.0	305.0	73.0	-0.057	0.051	1000.0	-1000.0	-0.054	-1000.0
PDGFR-beta signaling pathway	4.0	482.0	97.0	-0.127	0.065	1000.0	-1000.0	-0.07	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	137.0	37.0	-0.027	0.062	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class III	3.0	155.0	40.0	-0.051	0.052	1000.0	-1000.0	-0.029	-1000.0
ceramide signaling pathway	3.0	167.0	49.0	-0.008	0.04	1000.0	-1000.0	-0.043	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	54.0	15.0	-0.014	0.028	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	393.0	125.0	-0.009	0.066	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	240.0	76.0	-0.039	0.064	1000.0	-1000.0	-0.066	-1000.0
S1P3 pathway	3.0	166.0	42.0	-0.029	0.051	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in keratinocytes	3.0	152.0	43.0	-0.056	0.066	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	3.0	9.0	3.0	-0.02	0.02	1000.0	-1000.0	-0.005	-1000.0
Aurora B signaling	3.0	217.0	67.0	-0.078	0.073	1000.0	-1000.0	-0.04	-1000.0
Canonical NF-kappaB pathway	2.0	83.0	39.0	-0.008	0.057	1000.0	-1000.0	-0.041	-1000.0
Aurora A signaling	2.0	147.0	60.0	-0.039	0.055	1000.0	-1000.0	-0.022	-1000.0
Arf6 downstream pathway	2.0	109.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.033	-1000.0
EPO signaling pathway	2.0	164.0	55.0	-0.005	0.058	1000.0	-1000.0	-0.058	-1000.0
Signaling events mediated by HDAC Class I	2.0	226.0	104.0	-0.053	0.069	1000.0	-1000.0	-0.041	-1000.0
FoxO family signaling	2.0	128.0	64.0	-0.048	0.064	1000.0	-1000.0	-0.073	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	101.0	36.0	-0.049	0.056	1000.0	-1000.0	-0.044	-1000.0
Rapid glucocorticoid signaling	2.0	46.0	20.0	-0.001	0.034	1000.0	-1000.0	-0.004	-1000.0
Signaling events mediated by PRL	2.0	72.0	34.0	-0.036	0.041	1000.0	-1000.0	-0.051	-1000.0
p38 MAPK signaling pathway	2.0	102.0	44.0	-0.024	0.053	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by HDAC Class II	1.0	111.0	75.0	-0.033	0.072	1000.0	-1000.0	-0.037	-1000.0
BARD1 signaling events	1.0	113.0	57.0	-0.035	0.064	1000.0	-1000.0	-0.057	-1000.0
PLK2 and PLK4 events	1.0	5.0	3.0	0.007	0.025	1000.0	-1000.0	-0.009	-1000.0
Circadian rhythm pathway	1.0	38.0	22.0	-0.007	0.046	1000.0	-1000.0	-0.046	-1000.0
Aurora C signaling	1.0	9.0	7.0	-0.0	0.045	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	1.0	38.0	32.0	-0.0	0.053	1000.0	-1000.0	-0.038	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	128.0	68.0	-0.042	0.058	1000.0	-1000.0	-0.04	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	159.0	83.0	-0.011	0.052	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	1.0	33.0	31.0	-0.0	0.029	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	1.0	112.0	71.0	-0.043	0.052	1000.0	-1000.0	-0.035	-1000.0
VEGFR1 specific signals	1.0	111.0	56.0	-0.026	0.065	1000.0	-1000.0	-0.06	-1000.0
Alternative NF-kappaB pathway	1.0	15.0	13.0	0.0	0.068	1000.0	-1000.0	0.0	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	6.0	23.0	0.004	0.053	1000.0	-1000.0	-0.033	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	25.0	27.0	-0.01	0.062	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling events	0.0	2.0	5.0	0.026	0.048	1000.0	-1000.0	0.008	-1000.0
Arf1 pathway	0.0	47.0	54.0	-0.002	0.039	1000.0	-1000.0	-0.019	-1000.0
Total	1052	63958	7203	-10.0888183406	7.05829270914	131000	-131000	-6.23529905105	-131000