E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.016 0.061 -9999.0 0.0 -0.366 15.0 15.0 KLHL20 -0.046 0.068 0.301 1.0 -0.241 12.0 13.0 CYFIP2 -0.012 0.042 -9999.0 0.0 -0.308 11.0 11.0 Rac1/GDP -0.022 0.042 -9999.0 0.0 -0.24 15.0 15.0 ENAH -0.017 0.06 -9999.0 0.0 -0.366 15.0 15.0 AP1M1 -0.004 0.018 0.242 3.0 -9999.0 0.0 3.0 RAP1B -0.004 0.023 0.242 5.0 -9999.0 0.0 5.0 RAP1A -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 CTNNB1 -0.005 0.015 0.242 2.0 -9999.0 0.0 2.0 CDC42/GTP -0.023 0.029 -9999.0 0.0 -0.167 15.0 15.0 ABI1/Sra1/Nap1 -0.037 0.045 -9999.0 0.0 -0.108 143.0 143.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.002 0.029 0.151 2.0 -0.161 14.0 16.0 RAPGEF1 -0.019 0.053 -9999.0 0.0 -0.348 13.0 13.0 CTNND1 -0.006 0.001 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.015 0.062 -9999.0 0.0 -0.375 15.0 15.0 CRK -0.018 0.057 -9999.0 0.0 -0.372 13.0 13.0 E-cadherin/gamma catenin/alpha catenin -0.005 0.042 -9999.0 0.0 -0.189 26.0 26.0 alphaE/beta7 Integrin -0.007 0.011 0.17 1.0 -0.212 1.0 2.0 IQGAP1 -0.006 0.021 0.242 1.0 -0.308 2.0 3.0 NCKAP1 -0.002 0.031 0.242 9.0 -9999.0 0.0 9.0 Rap1/GTP/I-afadin -0.003 0.04 0.148 6.0 -0.159 29.0 35.0 DLG1 -0.003 0.073 -9999.0 0.0 -0.367 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.039 -9999.0 0.0 -0.157 16.0 16.0 MLLT4 -0.021 0.066 -9999.0 0.0 -0.308 29.0 29.0 ARF6/GTP/NME1/Tiam1 0.011 0.035 0.147 31.0 -0.159 2.0 33.0 PI3K -0.039 0.049 -9999.0 0.0 -0.2 16.0 16.0 ARF6 -0.006 0.013 -9999.0 0.0 -0.308 1.0 1.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.016 0.045 -9999.0 0.0 -0.227 24.0 24.0 TIAM1 -0.006 0.019 0.242 2.0 -0.308 1.0 3.0 E-cadherin(dimer)/Ca2+ 0.001 0.028 0.139 2.0 -0.15 15.0 17.0 AKT1 -0.025 0.03 -9999.0 0.0 -0.122 15.0 15.0 PIK3R1 -0.075 0.127 -9999.0 0.0 -0.308 131.0 131.0 CDH1 -0.013 0.045 -9999.0 0.0 -0.308 13.0 13.0 RhoA/GDP -0.02 0.041 -9999.0 0.0 -0.238 15.0 15.0 actin cytoskeleton organization -0.034 0.051 0.254 1.0 -0.178 11.0 12.0 CDC42/GDP -0.02 0.041 -9999.0 0.0 -0.238 15.0 15.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.012 0.042 -9999.0 0.0 -0.197 26.0 26.0 ITGB7 -0.006 0.016 0.242 1.0 -0.308 1.0 2.0 RAC1 -0.006 0.013 -9999.0 0.0 -0.308 1.0 1.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.001 0.03 0.149 2.0 -0.161 15.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.0 0.026 0.137 2.0 -0.148 15.0 17.0 mol:GDP -0.021 0.047 -9999.0 0.0 -0.271 15.0 15.0 CDC42/GTP/IQGAP1 0.003 0.013 0.154 1.0 -0.175 2.0 3.0 JUP -0.013 0.045 -9999.0 0.0 -0.308 13.0 13.0 p120 catenin/RhoA/GDP -0.021 0.042 -9999.0 0.0 -0.245 14.0 14.0 RAC1/GTP/IQGAP1 0.002 0.015 0.154 1.0 -0.175 3.0 4.0 PIP5K1C/AP1M1 -0.006 0.013 0.17 3.0 -9999.0 0.0 3.0 RHOA -0.007 0.018 -9999.0 0.0 -0.308 2.0 2.0 CDC42 -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 -0.007 0.018 -9999.0 0.0 -0.308 2.0 2.0 positive regulation of S phase of mitotic cell cycle -0.045 0.07 0.355 1.0 -0.158 148.0 149.0 NME1 0.007 0.054 0.242 29.0 -9999.0 0.0 29.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.016 0.061 -9999.0 0.0 -0.366 15.0 15.0 regulation of cell-cell adhesion -0.021 0.026 -9999.0 0.0 -0.149 15.0 15.0 WASF2 -0.031 0.035 -9999.0 0.0 -0.113 39.0 39.0 Rap1/GTP -0.022 0.035 0.114 5.0 -0.233 5.0 10.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.004 0.039 -9999.0 0.0 -0.163 27.0 27.0 CCND1 -0.056 0.086 0.394 1.0 -0.194 149.0 150.0 VAV2 -0.022 0.078 -9999.0 0.0 -0.444 16.0 16.0 RAP1/GDP -0.02 0.039 -9999.0 0.0 -0.206 14.0 14.0 adherens junction assembly -0.016 0.059 -9999.0 0.0 -0.356 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 -0.005 0.01 0.242 1.0 -9999.0 0.0 1.0 PIP5K1C -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.019 0.034 -9999.0 0.0 -0.279 2.0 2.0 E-cadherin/beta catenin -0.008 0.039 -9999.0 0.0 -0.267 12.0 12.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.017 0.06 -9999.0 0.0 -0.367 15.0 15.0 PIK3CA 0.047 0.102 0.242 122.0 -9999.0 0.0 122.0 Rac1/GTP -0.07 0.105 0.404 1.0 -0.297 31.0 32.0 E-cadherin/beta catenin/alpha catenin -0.0 0.031 0.155 2.0 -0.177 15.0 17.0 ITGAE -0.006 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.015 0.063 -9999.0 0.0 -0.383 15.0 15.0