E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.103 -9999.0 0.0 -0.324 64.0 64.0 KLHL20 -0.059 0.078 0.476 1.0 -0.272 18.0 19.0 CYFIP2 0.028 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.046 0.079 0.246 4.0 -0.256 16.0 20.0 ENAH -0.048 0.104 -9999.0 0.0 -0.322 66.0 66.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 67.0 67.0 RAP1B 0.029 0.006 -9999.0 0.0 0.0 22.0 22.0 RAP1A 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CTNNB1 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42/GTP -0.059 0.05 0.124 6.0 -0.233 2.0 8.0 ABI1/Sra1/Nap1 -0.053 0.045 -9999.0 0.0 -0.169 34.0 34.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.048 -9999.0 0.0 -0.141 9.0 9.0 RAPGEF1 -0.048 0.1 0.25 3.0 -0.307 56.0 59.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.024 0.115 -9999.0 0.0 -0.322 69.0 69.0 CRK -0.047 0.102 -9999.0 0.0 -0.318 61.0 61.0 E-cadherin/gamma catenin/alpha catenin 0.043 0.044 -9999.0 0.0 -0.156 20.0 20.0 alphaE/beta7 Integrin 0.041 0.014 -9999.0 0.0 -0.163 1.0 1.0 IQGAP1 0.028 0.006 -9999.0 0.0 0.0 25.0 25.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.042 -9999.0 0.0 -0.13 21.0 21.0 DLG1 -0.034 0.104 0.194 1.0 -0.325 54.0 55.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.044 0.042 -9999.0 0.0 -0.151 13.0 13.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 70.0 70.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.13 1.0 1.0 PI3K -0.054 0.054 -9999.0 0.0 -0.207 7.0 7.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.03 0.042 -9999.0 0.0 -0.175 19.0 19.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 21.0 21.0 E-cadherin(dimer)/Ca2+ 0.052 0.043 -9999.0 0.0 -0.132 9.0 9.0 AKT1 -0.013 0.069 0.136 52.0 -0.145 1.0 53.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 161.0 161.0 CDH1 0.026 0.01 -9999.0 0.0 -0.0 74.0 74.0 RhoA/GDP -0.046 0.078 0.237 4.0 -0.257 15.0 19.0 actin cytoskeleton organization -0.043 0.058 0.412 1.0 -0.21 10.0 11.0 CDC42/GDP -0.045 0.079 0.237 5.0 -0.257 15.0 20.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.015 0.059 -9999.0 0.0 -0.188 37.0 37.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 9.0 9.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 29.0 29.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.047 -9999.0 0.0 -0.141 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.033 -9999.0 0.0 -0.121 9.0 9.0 mol:GDP -0.044 0.084 0.249 4.0 -0.277 21.0 25.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.133 2.0 2.0 JUP 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 p120 catenin/RhoA/GDP -0.049 0.081 0.242 4.0 -0.259 16.0 20.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.133 2.0 2.0 PIP5K1C/AP1M1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 6.0 6.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 positive regulation of S phase of mitotic cell cycle -0.045 0.057 0.115 1.0 -0.13 140.0 141.0 NME1 0.027 0.008 -9999.0 0.0 0.0 43.0 43.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.049 0.106 -9999.0 0.0 -0.323 68.0 68.0 regulation of cell-cell adhesion -0.054 0.041 0.083 20.0 -0.206 2.0 22.0 WASF2 -0.031 0.035 0.09 4.0 -0.104 35.0 39.0 Rap1/GTP -0.055 0.058 0.252 2.0 -0.251 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.064 -9999.0 0.0 -0.151 20.0 20.0 CCND1 -0.055 0.069 0.132 1.0 -0.159 141.0 142.0 VAV2 -0.041 0.165 -9999.0 0.0 -0.652 24.0 24.0 RAP1/GDP -0.046 0.066 0.254 3.0 -0.245 4.0 7.0 adherens junction assembly -0.048 0.103 -9999.0 0.0 -0.315 68.0 68.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 15.0 15.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.228 2.0 6.0 E-cadherin/beta catenin -0.012 0.05 -9999.0 0.0 -0.18 41.0 41.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.046 0.102 -9999.0 0.0 -0.326 62.0 62.0 PIK3CA 0.021 0.014 -9999.0 0.0 0.0 171.0 171.0 Rac1/GTP -0.089 0.112 0.568 1.0 -0.389 36.0 37.0 E-cadherin/beta catenin/alpha catenin 0.048 0.032 -9999.0 0.0 -0.146 9.0 9.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.025 0.117 -9999.0 0.0 -0.328 69.0 69.0