Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.04 0.021 0.197 1.0 -9999.0 0.0 1.0 KIRREL -0.022 0.03 0.049 67.0 -9999.0 0.0 67.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.041 0.022 -9999.0 0.0 -0.197 1.0 1.0 PLCG1 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 ARRB2 0.028 0.006 -9999.0 0.0 0.0 26.0 26.0 WASL 0.029 0.006 -9999.0 0.0 0.0 22.0 22.0 Nephrin/NEPH1/podocin/CD2AP 0.067 0.038 0.201 1.0 -9999.0 0.0 1.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.014 0.034 0.165 1.0 -0.19 1.0 2.0 FYN -0.004 0.064 0.145 76.0 -0.214 1.0 77.0 mol:Ca2+ 0.061 0.038 -9999.0 0.0 -0.168 1.0 1.0 mol:DAG 0.063 0.039 -9999.0 0.0 -0.168 1.0 1.0 NPHS2 -0.02 0.033 0.051 80.0 -9999.0 0.0 80.0 mol:IP3 0.063 0.039 -9999.0 0.0 -0.168 1.0 1.0 regulation of endocytosis 0.032 0.053 -9999.0 0.0 -0.211 1.0 1.0 Nephrin/NEPH1/podocin/Cholesterol 0.052 0.031 0.163 3.0 -0.157 1.0 4.0 establishment of cell polarity 0.04 0.021 -9999.0 0.0 -0.197 1.0 1.0 Nephrin/NEPH1/podocin/NCK1-2 0.082 0.047 -9999.0 0.0 -0.163 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.034 0.054 -9999.0 0.0 -0.213 1.0 1.0 NPHS1 -0.024 0.027 0.053 38.0 -9999.0 0.0 38.0 Nephrin/NEPH1/podocin 0.03 0.049 0.188 3.0 -0.215 1.0 4.0 TJP1 0.028 0.008 -9999.0 0.0 0.0 39.0 39.0 NCK1 0.026 0.009 -9999.0 0.0 0.0 63.0 63.0 NCK2 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.067 0.039 -9999.0 0.0 -0.169 1.0 1.0 CD2AP 0.028 0.007 -9999.0 0.0 0.0 31.0 31.0 Nephrin/NEPH1/podocin/GRB2 0.067 0.039 0.201 1.0 -0.169 1.0 2.0 GRB2 0.029 0.006 -9999.0 0.0 0.0 20.0 20.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.013 0.072 0.151 82.0 -0.152 1.0 83.0 cytoskeleton organization -0.017 0.048 0.201 12.0 -0.205 1.0 13.0 Nephrin/NEPH1 0.034 0.018 -9999.0 0.0 -0.129 1.0 1.0 Nephrin/NEPH1/ZO-1 0.049 0.03 -9999.0 0.0 -0.163 1.0 1.0