Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.073 0.272 -9999.0 0.0 -0.918 22.0 22.0 IHH -0.069 0.172 -9999.0 0.0 -0.43 50.0 50.0 SHH Np/Cholesterol/GAS1 -0.08 0.181 -9999.0 0.0 -0.505 35.0 35.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.079 0.18 0.501 35.0 -9999.0 0.0 35.0 SMO/beta Arrestin2 -0.03 0.135 -9999.0 0.0 -0.601 6.0 6.0 SMO -0.037 0.142 -9999.0 0.0 -0.637 6.0 6.0 AKT1 -0.001 0.069 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.013 0.112 -9999.0 0.0 -0.499 14.0 14.0 ADRBK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.037 0.14 -9999.0 0.0 -0.626 6.0 6.0 STIL -0.08 0.173 -9999.0 0.0 -0.545 15.0 15.0 DHH N/PTCH2 -0.035 0.139 -9999.0 0.0 -0.373 39.0 39.0 DHH N/PTCH1 -0.048 0.159 -9999.0 0.0 -0.527 16.0 16.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.025 0.146 -9999.0 0.0 -0.581 18.0 18.0 PTHLH -0.07 0.294 -9999.0 0.0 -0.96 22.0 22.0 determination of left/right symmetry -0.037 0.14 -9999.0 0.0 -0.626 6.0 6.0 PIK3R1 0.008 0.035 -9999.0 0.0 -0.411 2.0 2.0 skeletal system development -0.068 0.287 -9999.0 0.0 -0.939 22.0 22.0 IHH N/Hhip -0.133 0.224 -9999.0 0.0 -0.55 53.0 53.0 DHH N/Hhip -0.107 0.215 -9999.0 0.0 -0.438 80.0 80.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.037 0.14 -9999.0 0.0 -0.626 6.0 6.0 pancreas development -0.119 0.255 -9999.0 0.0 -0.58 65.0 65.0 HHAT -0.018 0.144 -9999.0 0.0 -0.718 12.0 12.0 PI3K 0.015 0.024 -9999.0 0.0 -0.28 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.03 0.164 -9999.0 0.0 -0.667 18.0 18.0 somite specification -0.037 0.14 -9999.0 0.0 -0.626 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.086 0.177 -9999.0 0.0 -0.557 17.0 17.0 SHH Np/Cholesterol/PTCH2 -0.074 0.16 -9999.0 0.0 -0.445 34.0 34.0 SHH Np/Cholesterol/Megalin -0.195 0.225 -9999.0 0.0 -0.484 94.0 94.0 SHH -0.08 0.181 -9999.0 0.0 -0.572 22.0 22.0 catabolic process -0.037 0.146 -9999.0 0.0 -0.562 8.0 8.0 SMO/Vitamin D3 -0.077 0.177 -9999.0 0.0 -0.62 11.0 11.0 SHH Np/Cholesterol/Hhip -0.13 0.216 -9999.0 0.0 -0.495 62.0 62.0 LRP2 -0.235 0.299 -9999.0 0.0 -0.557 128.0 128.0 receptor-mediated endocytosis -0.167 0.206 -9999.0 0.0 -0.643 24.0 24.0 SHH Np/Cholesterol/BOC -0.069 0.158 -9999.0 0.0 -0.479 26.0 26.0 SHH Np/Cholesterol/CDO -0.06 0.153 -9999.0 0.0 -0.488 22.0 22.0 mesenchymal cell differentiation 0.129 0.214 0.491 62.0 -9999.0 0.0 62.0 mol:Vitamin D3 -0.084 0.178 -9999.0 0.0 -0.557 17.0 17.0 IHH N/PTCH2 -0.055 0.143 -9999.0 0.0 -0.46 19.0 19.0 CDON 0.003 0.069 -9999.0 0.0 -0.564 4.0 4.0 IHH N/PTCH1 -0.038 0.147 -9999.0 0.0 -0.568 8.0 8.0 Megalin/LRPAP1 -0.165 0.225 -9999.0 0.0 -0.54 61.0 61.0 PTCH2 -0.024 0.123 -9999.0 0.0 -0.438 23.0 23.0 SHH Np/Cholesterol -0.069 0.139 -9999.0 0.0 -0.459 22.0 22.0 PTCH1 -0.037 0.146 -9999.0 0.0 -0.564 8.0 8.0 HHIP -0.119 0.255 -9999.0 0.0 -0.581 65.0 65.0