Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.05 -9999.0 0.0 -0.303 7.0 7.0 epithelial cell differentiation -0.009 0.059 -9999.0 0.0 -0.392 7.0 7.0 CYFIP2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.045 0.05 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.013 0.125 -9999.0 0.0 -0.634 11.0 11.0 EPHA2 0.007 0.049 -9999.0 0.0 -0.564 2.0 2.0 MYO6 0.021 0.072 -9999.0 0.0 -0.426 7.0 7.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.023 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.082 0.189 -9999.0 0.0 -0.567 36.0 36.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.022 0.06 -9999.0 0.0 -0.365 7.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.129 -9999.0 0.0 -0.381 31.0 31.0 EGF -0.061 0.193 -9999.0 0.0 -0.537 39.0 39.0 NCKAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.028 0.106 -9999.0 0.0 -0.53 10.0 10.0 cortical microtubule organization -0.009 0.059 -9999.0 0.0 -0.392 7.0 7.0 GO:0000145 0.021 0.057 -9999.0 0.0 -0.349 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.017 0.064 -9999.0 0.0 -0.396 7.0 7.0 MLLT4 0.006 0.06 -9999.0 0.0 -0.718 2.0 2.0 ARF6/GDP -0.01 0.054 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.041 -9999.0 0.0 -0.418 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.031 0.059 -9999.0 0.0 -0.341 7.0 7.0 PVRL2 0.009 0.042 -9999.0 0.0 -0.718 1.0 1.0 ZYX 0.022 0.061 -9999.0 0.0 -0.371 7.0 7.0 ARF6/GTP -0.004 0.035 -9999.0 0.0 -0.384 2.0 2.0 CDH1 -0.004 0.103 -9999.0 0.0 -0.718 6.0 6.0 EGFR/EGFR/EGF/EGF -0.052 0.115 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP -0.009 0.056 -9999.0 0.0 -0.367 7.0 7.0 actin cytoskeleton organization 0.025 0.078 -9999.0 0.0 -0.697 2.0 2.0 IGF-1R heterotetramer -0.014 0.131 -9999.0 0.0 -0.717 10.0 10.0 GIT1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.014 0.132 -9999.0 0.0 -0.718 10.0 10.0 IGF1 -0.027 0.146 -9999.0 0.0 -0.549 20.0 20.0 DIAPH1 -0.001 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.009 0.059 0.392 7.0 -9999.0 0.0 7.0 RHOA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.01 0.054 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.009 0.042 -9999.0 0.0 -0.718 1.0 1.0 VCL 0.025 0.08 -9999.0 0.0 -0.724 2.0 2.0 EFNA1 0.007 0.049 -9999.0 0.0 -0.564 2.0 2.0 LPP 0.026 0.063 -9999.0 0.0 -0.35 8.0 8.0 Ephrin A1/EPHA2 -0.012 0.062 -9999.0 0.0 -0.359 2.0 2.0 SEC6/SEC8 -0.011 0.065 -9999.0 0.0 -0.669 1.0 1.0 MGAT3 -0.014 0.131 -9999.0 0.0 -0.387 31.0 31.0 HGF/MET -0.046 0.13 -9999.0 0.0 -0.654 5.0 5.0 HGF -0.008 0.111 -9999.0 0.0 -0.616 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.05 -9999.0 0.0 -0.305 7.0 7.0 actin cable formation 0.059 0.046 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.019 0.11 -9999.0 0.0 -0.553 9.0 9.0 KIFC3 0.022 0.061 -9999.0 0.0 -0.371 7.0 7.0 NCK1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.022 0.061 -9999.0 0.0 -0.371 7.0 7.0 NCK1/GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.009 0.059 -9999.0 0.0 -0.392 7.0 7.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.022 0.061 -9999.0 0.0 -0.371 7.0 7.0 PIP5K1C 0.022 0.061 -9999.0 0.0 -0.371 7.0 7.0 LIMA1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.041 0.057 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.033 0.101 -9999.0 0.0 -0.722 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.038 0.116 -9999.0 0.0 -0.414 20.0 20.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.011 0.056 -9999.0 0.0 -0.54 3.0 3.0 MET -0.05 0.192 -9999.0 0.0 -0.63 28.0 28.0 PLEKHA7 0.019 0.076 -9999.0 0.0 -0.419 8.0 8.0 mol:GTP -0.004 0.038 -9999.0 0.0 -0.415 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.039 0.07 -9999.0 0.0 -0.632 1.0 1.0 cortical actin cytoskeleton stabilization 0.018 0.05 -9999.0 0.0 -0.303 7.0 7.0 regulation of cell-cell adhesion 0.025 0.078 -9999.0 0.0 -0.697 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.05 -9999.0 0.0 -0.305 7.0 7.0