Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	58.0	465.0	8.0	-0.141	0.074	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	47.0	4284.0	91.0	-0.803	0.681	1000.0	-1000.0	-0.183	-1000.0
FOXA2 and FOXA3 transcription factor networks	46.0	2143.0	46.0	-0.612	0.011	1000.0	-1000.0	-0.099	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	43.0	1489.0	34.0	-0.154	0.011	1000.0	-1000.0	-0.059	-1000.0
Signaling events regulated by Ret tyrosine kinase	40.0	3301.0	82.0	-0.221	0.011	1000.0	-1000.0	-0.091	-1000.0
IL23-mediated signaling events	33.0	2035.0	60.0	-0.471	0.011	1000.0	-1000.0	-0.201	-1000.0
Wnt signaling	32.0	226.0	7.0	-0.145	-0.025	1000.0	-1000.0	-0.039	-1000.0
Syndecan-1-mediated signaling events	30.0	1043.0	34.0	-0.212	0.011	1000.0	-1000.0	-0.066	-1000.0
TCGA08_p53	29.0	205.0	7.0	-0.114	0.066	1000.0	-1000.0	-0.024	-1000.0
Syndecan-4-mediated signaling events	29.0	2009.0	67.0	-0.207	0.016	1000.0	-1000.0	-0.093	-1000.0
TCR signaling in naïve CD8+ T cells	27.0	2590.0	93.0	-0.16	0.02	1000.0	-1000.0	-0.092	-1000.0
amb2 Integrin signaling	26.0	2150.0	82.0	-0.254	0.014	1000.0	-1000.0	-0.088	-1000.0
Visual signal transduction: Cones	25.0	959.0	38.0	-0.17	0.011	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by the Hedgehog family	24.0	1293.0	52.0	-0.235	0.129	1000.0	-1000.0	-0.081	-1000.0
Noncanonical Wnt signaling pathway	24.0	629.0	26.0	-0.145	0.011	1000.0	-1000.0	-0.066	-1000.0
Glypican 2 network	24.0	99.0	4.0	-0.028	-0.028	1000.0	-1000.0	-0.023	-1000.0
Class IB PI3K non-lipid kinase events	23.0	69.0	3.0	-0.034	-1000.0	1000.0	-1000.0	-0.02	-1000.0
IL12-mediated signaling events	22.0	1957.0	87.0	-0.236	0.035	1000.0	-1000.0	-0.142	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1557.0	68.0	-0.281	0.119	1000.0	-1000.0	-0.152	-1000.0
BMP receptor signaling	21.0	1716.0	81.0	-0.255	0.037	1000.0	-1000.0	-0.097	-1000.0
Endothelins	21.0	2069.0	96.0	-0.201	0.012	1000.0	-1000.0	-0.098	-1000.0
Ephrin B reverse signaling	20.0	1005.0	48.0	-0.145	0.015	1000.0	-1000.0	-0.081	-1000.0
Effects of Botulinum toxin	20.0	528.0	26.0	-0.16	0.014	1000.0	-1000.0	-0.067	-1000.0
Visual signal transduction: Rods	20.0	1073.0	52.0	-0.146	0.011	1000.0	-1000.0	-0.084	-1000.0
Thromboxane A2 receptor signaling	19.0	2004.0	105.0	-0.12	0.035	1000.0	-1000.0	-0.073	-1000.0
p75(NTR)-mediated signaling	19.0	2379.0	125.0	-0.187	0.033	1000.0	-1000.0	-0.125	-1000.0
Glypican 1 network	19.0	956.0	48.0	-0.191	0.021	1000.0	-1000.0	-0.059	-1000.0
Caspase cascade in apoptosis	18.0	1403.0	74.0	-0.167	0.062	1000.0	-1000.0	-0.047	-1000.0
Fc-epsilon receptor I signaling in mast cells	18.0	1785.0	97.0	-0.157	0.029	1000.0	-1000.0	-0.084	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	18.0	957.0	52.0	-0.212	0.032	1000.0	-1000.0	-0.057	-1000.0
Glucocorticoid receptor regulatory network	17.0	1975.0	114.0	-0.415	0.236	1000.0	-1000.0	-0.089	-1000.0
Reelin signaling pathway	17.0	955.0	56.0	-0.196	0.027	1000.0	-1000.0	-0.091	-1000.0
Calcium signaling in the CD4+ TCR pathway	17.0	527.0	31.0	-0.159	0.011	1000.0	-1000.0	-0.09	-1000.0
BCR signaling pathway	17.0	1703.0	99.0	-0.186	0.017	1000.0	-1000.0	-0.095	-1000.0
ErbB4 signaling events	16.0	1128.0	69.0	-0.219	0.146	1000.0	-1000.0	-0.092	-1000.0
Ephrin A  reverse signaling	16.0	116.0	7.0	-0.027	-0.0	1000.0	-1000.0	-0.027	-1000.0
HIF-1-alpha transcription factor network	16.0	1251.0	76.0	-0.249	0.045	1000.0	-1000.0	-0.217	-1000.0
LPA4-mediated signaling events	15.0	190.0	12.0	-0.147	0.016	1000.0	-1000.0	-0.029	-1000.0
Retinoic acid receptors-mediated signaling	14.0	831.0	58.0	-0.203	0.023	1000.0	-1000.0	-0.087	-1000.0
Nongenotropic Androgen signaling	14.0	734.0	52.0	-0.085	0.013	1000.0	-1000.0	-0.067	-1000.0
IL27-mediated signaling events	14.0	721.0	51.0	-0.115	0.057	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by PTP1B	13.0	993.0	76.0	-0.1	0.028	1000.0	-1000.0	-0.076	-1000.0
LPA receptor mediated events	13.0	1378.0	102.0	-0.115	0.021	1000.0	-1000.0	-0.104	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1619.0	120.0	-0.222	0.05	1000.0	-1000.0	-0.078	-1000.0
Coregulation of Androgen receptor activity	12.0	937.0	76.0	-0.175	0.019	1000.0	-1000.0	-0.064	-1000.0
Signaling events mediated by HDAC Class III	12.0	491.0	40.0	-0.182	0.101	1000.0	-1000.0	-0.047	-1000.0
Syndecan-3-mediated signaling events	12.0	445.0	35.0	-0.165	0.033	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	974.0	78.0	-0.075	0.036	1000.0	-1000.0	-0.085	-1000.0
ErbB2/ErbB3 signaling events	11.0	741.0	65.0	-0.144	0.016	1000.0	-1000.0	-0.075	-1000.0
Osteopontin-mediated events	11.0	454.0	38.0	-0.097	0.012	1000.0	-1000.0	-0.12	-1000.0
Syndecan-2-mediated signaling events	11.0	802.0	69.0	-0.091	0.024	1000.0	-1000.0	-0.066	-1000.0
EPHB forward signaling	11.0	958.0	85.0	-0.077	0.069	1000.0	-1000.0	-0.106	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	11.0	364.0	33.0	-0.15	0.032	1000.0	-1000.0	-0.075	-1000.0
Regulation of nuclear SMAD2/3 signaling	10.0	1418.0	136.0	-0.251	0.151	1000.0	-1000.0	-0.08	-1000.0
BARD1 signaling events	10.0	585.0	57.0	-0.055	0.072	1000.0	-1000.0	-0.075	-1000.0
Cellular roles of Anthrax toxin	10.0	390.0	39.0	-0.087	0.012	1000.0	-1000.0	-0.03	-1000.0
Arf6 signaling events	10.0	621.0	62.0	-0.103	0.024	1000.0	-1000.0	-0.075	-1000.0
FAS signaling pathway (CD95)	10.0	487.0	47.0	-0.107	0.012	1000.0	-1000.0	-0.063	-1000.0
Canonical Wnt signaling pathway	10.0	558.0	51.0	-0.146	0.042	1000.0	-1000.0	-0.068	-1000.0
IL6-mediated signaling events	10.0	769.0	75.0	-0.139	0.04	1000.0	-1000.0	-0.1	-1000.0
Plasma membrane estrogen receptor signaling	10.0	872.0	86.0	-0.085	0.019	1000.0	-1000.0	-0.099	-1000.0
Regulation of Androgen receptor activity	10.0	726.0	70.0	-0.211	0.024	1000.0	-1000.0	-0.084	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	500.0	54.0	-0.158	0.022	1000.0	-1000.0	-0.118	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	153.0	17.0	-0.049	0.011	1000.0	-1000.0	-0.066	-1000.0
Presenilin action in Notch and Wnt signaling	9.0	581.0	61.0	-0.135	0.03	1000.0	-1000.0	-0.084	-1000.0
Nectin adhesion pathway	9.0	579.0	63.0	-0.052	0.018	1000.0	-1000.0	-0.084	-1000.0
Integrins in angiogenesis	9.0	778.0	84.0	-0.106	0.019	1000.0	-1000.0	-0.104	-1000.0
EGFR-dependent Endothelin signaling events	9.0	192.0	21.0	-0.079	0.017	1000.0	-1000.0	-0.085	-1000.0
Angiopoietin receptor Tie2-mediated signaling	9.0	817.0	88.0	-0.092	0.036	1000.0	-1000.0	-0.131	-1000.0
Ras signaling in the CD4+ TCR pathway	9.0	164.0	17.0	-0.029	0.014	1000.0	-1000.0	-0.051	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	8.0	741.0	85.0	-0.06	0.024	1000.0	-1000.0	-0.087	-1000.0
TRAIL signaling pathway	8.0	397.0	48.0	-0.038	0.022	1000.0	-1000.0	-0.077	-1000.0
S1P1 pathway	8.0	321.0	36.0	-0.086	0.011	1000.0	-1000.0	-0.071	-1000.0
IL2 signaling events mediated by STAT5	8.0	183.0	22.0	-0.06	0.012	1000.0	-1000.0	-0.081	-1000.0
FOXM1 transcription factor network	8.0	448.0	51.0	-0.157	0.107	1000.0	-1000.0	-0.207	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	7.0	269.0	37.0	-0.061	0.023	1000.0	-1000.0	-0.065	-1000.0
IL1-mediated signaling events	7.0	492.0	62.0	-0.068	0.055	1000.0	-1000.0	-0.105	-1000.0
S1P5 pathway	7.0	130.0	17.0	-0.085	0.041	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by PI3K	7.0	425.0	58.0	-0.069	0.027	1000.0	-1000.0	-0.099	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	7.0	324.0	45.0	-0.089	0.025	1000.0	-1000.0	-0.104	-1000.0
IGF1 pathway	7.0	449.0	57.0	-0.036	0.023	1000.0	-1000.0	-0.103	-1000.0
S1P4 pathway	7.0	179.0	25.0	-0.085	0.015	1000.0	-1000.0	-0.063	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	195.0	28.0	-0.085	0.017	1000.0	-1000.0	-0.044	-1000.0
Ceramide signaling pathway	6.0	490.0	76.0	-0.084	0.03	1000.0	-1000.0	-0.062	-1000.0
Regulation of p38-alpha and p38-beta	6.0	341.0	54.0	-0.116	0.029	1000.0	-1000.0	-0.078	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	455.0	74.0	-0.082	0.059	1000.0	-1000.0	-0.097	-1000.0
Regulation of Telomerase	6.0	646.0	102.0	-0.155	0.031	1000.0	-1000.0	-0.109	-1000.0
S1P3 pathway	6.0	272.0	42.0	-0.085	0.019	1000.0	-1000.0	-0.055	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	26.0	5.0	-0.008	0.009	1000.0	-1000.0	-0.03	-1000.0
Aurora A signaling	5.0	324.0	60.0	-0.088	0.028	1000.0	-1000.0	-0.066	-1000.0
EPO signaling pathway	5.0	323.0	55.0	-0.023	0.038	1000.0	-1000.0	-0.109	-1000.0
IFN-gamma pathway	5.0	396.0	68.0	-0.084	0.031	1000.0	-1000.0	-0.107	-1000.0
HIF-2-alpha transcription factor network	5.0	249.0	43.0	-0.047	0.048	1000.0	-1000.0	-0.106	-1000.0
TCGA08_rtk_signaling	5.0	148.0	26.0	-0.05	0.032	1000.0	-1000.0	-0.026	-1000.0
Class I PI3K signaling events	5.0	430.0	73.0	-0.098	0.028	1000.0	-1000.0	-0.074	-1000.0
Rapid glucocorticoid signaling	5.0	106.0	20.0	-0.044	0.013	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by PRL	5.0	190.0	34.0	-0.091	0.018	1000.0	-1000.0	-0.055	-1000.0
PLK2 and PLK4 events	4.0	12.0	3.0	-0.002	0.011	1000.0	-1000.0	-0.019	-1000.0
Hedgehog signaling events mediated by Gli proteins	4.0	319.0	65.0	-0.252	0.039	1000.0	-1000.0	-0.081	-1000.0
ceramide signaling pathway	4.0	234.0	49.0	-0.084	0.02	1000.0	-1000.0	-0.066	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	4.0	347.0	83.0	-0.169	0.043	1000.0	-1000.0	-0.076	-1000.0
Signaling events mediated by HDAC Class I	4.0	449.0	104.0	-0.084	0.044	1000.0	-1000.0	-0.074	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	218.0	44.0	-0.092	0.019	1000.0	-1000.0	-0.061	-1000.0
PDGFR-beta signaling pathway	4.0	481.0	97.0	-0.074	0.036	1000.0	-1000.0	-0.089	-1000.0
Aurora B signaling	4.0	270.0	67.0	-0.09	0.02	1000.0	-1000.0	-0.086	-1000.0
Canonical NF-kappaB pathway	3.0	126.0	39.0	-0.084	0.056	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by HDAC Class II	3.0	272.0	75.0	-0.055	0.032	1000.0	-1000.0	-0.057	-1000.0
Aurora C signaling	3.0	25.0	7.0	-0.014	0.004	1000.0	-1000.0	-0.03	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	49.0	15.0	-0.025	0.025	1000.0	-1000.0	-0.042	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	129.0	36.0	-0.061	0.028	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in the nascent adherens junction	3.0	299.0	76.0	-0.047	0.036	1000.0	-1000.0	-0.095	-1000.0
Insulin Pathway	3.0	234.0	74.0	-0.078	0.03	1000.0	-1000.0	-0.094	-1000.0
E-cadherin signaling events	3.0	18.0	5.0	-0.004	0.013	1000.0	-1000.0	-0.029	-1000.0
Circadian rhythm pathway	2.0	59.0	22.0	-0.028	0.03	1000.0	-1000.0	-0.057	-1000.0
PDGFR-alpha signaling pathway	2.0	90.0	44.0	-0.067	0.028	1000.0	-1000.0	-0.072	-1000.0
FoxO family signaling	2.0	153.0	64.0	-0.117	0.088	1000.0	-1000.0	-0.091	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	286.0	125.0	-0.052	0.063	1000.0	-1000.0	-0.101	-1000.0
E-cadherin signaling in keratinocytes	2.0	115.0	43.0	-0.059	0.033	1000.0	-1000.0	-0.074	-1000.0
p38 MAPK signaling pathway	2.0	125.0	44.0	-0.084	0.025	1000.0	-1000.0	-0.086	-1000.0
Arf6 downstream pathway	1.0	78.0	43.0	-0.018	0.019	1000.0	-1000.0	-0.053	-1000.0
PLK1 signaling events	1.0	156.0	85.0	-0.012	0.026	1000.0	-1000.0	-0.062	-1000.0
Insulin-mediated glucose transport	1.0	61.0	32.0	-0.046	0.023	1000.0	-1000.0	-0.073	-1000.0
mTOR signaling pathway	1.0	89.0	53.0	-0.004	0.028	1000.0	-1000.0	-0.064	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	84.0	68.0	-0.046	0.041	1000.0	-1000.0	-0.063	-1000.0
Atypical NF-kappaB pathway	1.0	33.0	31.0	-0.007	0.035	1000.0	-1000.0	-0.054	-1000.0
VEGFR1 specific signals	1.0	98.0	56.0	-0.02	0.049	1000.0	-1000.0	-0.081	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	13.0	23.0	0.006	0.036	1000.0	-1000.0	-0.06	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	2.0	27.0	0.0	0.028	1000.0	-1000.0	-0.05	-1000.0
Arf6 trafficking events	0.0	66.0	71.0	-0.056	0.036	1000.0	-1000.0	-0.084	-1000.0
Arf1 pathway	0.0	29.0	54.0	-0.011	0.025	1000.0	-1000.0	-0.039	-1000.0
Alternative NF-kappaB pathway	0.0	7.0	13.0	-0.002	0.032	1000.0	-1000.0	-0.05	-1000.0
Total	1539	88830	7203	-15.9131124849	-995.013565725	131000	-131000	-10.2414660448	-131000