Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.031 0.202 -9999.0 0.0 -0.728 21.0 21.0 IHH 0.007 0.078 -9999.0 0.0 -0.381 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.023 0.113 -9999.0 0.0 -0.335 31.0 31.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.023 0.112 0.333 31.0 -9999.0 0.0 31.0 SMO/beta Arrestin2 0.01 0.107 -9999.0 0.0 -0.404 8.0 8.0 SMO -0.012 0.104 -9999.0 0.0 -0.42 9.0 9.0 AKT1 -0.005 0.085 -9999.0 0.0 -0.407 2.0 2.0 ARRB2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.066 -9999.0 0.0 -0.533 4.0 4.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.01 0.105 -9999.0 0.0 -0.414 9.0 9.0 STIL -0.027 0.115 -9999.0 0.0 -0.3 29.0 29.0 DHH N/PTCH2 0.015 0.087 -9999.0 0.0 -0.391 12.0 12.0 DHH N/PTCH1 0.001 0.116 -9999.0 0.0 -0.332 29.0 29.0 PIK3CA 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.006 0.102 -9999.0 0.0 -0.533 10.0 10.0 PTHLH -0.038 0.229 -9999.0 0.0 -0.826 19.0 19.0 determination of left/right symmetry -0.01 0.105 -9999.0 0.0 -0.414 9.0 9.0 PIK3R1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.037 0.225 -9999.0 0.0 -0.813 19.0 19.0 IHH N/Hhip -0.035 0.154 -9999.0 0.0 -0.426 37.0 37.0 DHH N/Hhip -0.035 0.153 -9999.0 0.0 -0.393 44.0 44.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.01 0.105 -9999.0 0.0 -0.414 9.0 9.0 pancreas development -0.046 0.178 -9999.0 0.0 -0.532 34.0 34.0 HHAT 0.006 0.107 -9999.0 0.0 -0.533 11.0 11.0 PI3K 0.029 0.019 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.001 0.115 -9999.0 0.0 -0.533 13.0 13.0 somite specification -0.01 0.105 -9999.0 0.0 -0.414 9.0 9.0 SHH Np/Cholesterol/PTCH1 -0.024 0.114 -9999.0 0.0 -0.295 41.0 41.0 SHH Np/Cholesterol/PTCH2 -0.012 0.089 -9999.0 0.0 -0.32 20.0 20.0 SHH Np/Cholesterol/Megalin -0.078 0.148 -9999.0 0.0 -0.328 71.0 71.0 SHH -0.03 0.105 -9999.0 0.0 -0.409 20.0 20.0 catabolic process -0.003 0.103 -9999.0 0.0 -0.354 22.0 22.0 SMO/Vitamin D3 -0.02 0.123 -9999.0 0.0 -0.389 13.0 13.0 SHH Np/Cholesterol/Hhip -0.049 0.139 -9999.0 0.0 -0.343 48.0 48.0 LRP2 -0.1 0.217 -9999.0 0.0 -0.533 58.0 58.0 receptor-mediated endocytosis -0.068 0.149 -9999.0 0.0 -0.457 15.0 15.0 SHH Np/Cholesterol/BOC -0.013 0.093 -9999.0 0.0 -0.323 22.0 22.0 SHH Np/Cholesterol/CDO -0.01 0.096 -9999.0 0.0 -0.345 20.0 20.0 mesenchymal cell differentiation 0.049 0.138 0.34 48.0 -9999.0 0.0 48.0 mol:Vitamin D3 -0.019 0.12 -9999.0 0.0 -0.295 41.0 41.0 IHH N/PTCH2 0.02 0.064 -9999.0 0.0 -0.38 5.0 5.0 CDON 0.022 0.047 -9999.0 0.0 -0.533 2.0 2.0 IHH N/PTCH1 0.005 0.106 -9999.0 0.0 -0.356 22.0 22.0 Megalin/LRPAP1 -0.062 0.166 -9999.0 0.0 -0.391 58.0 58.0 PTCH2 0.018 0.049 -9999.0 0.0 -0.533 2.0 2.0 SHH Np/Cholesterol -0.015 0.085 -9999.0 0.0 -0.317 20.0 20.0 PTCH1 -0.004 0.103 -9999.0 0.0 -0.355 22.0 22.0 HHIP -0.046 0.178 -9999.0 0.0 -0.533 34.0 34.0