Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.017 0.039 -9999.0 0.0 -0.247 5.0 5.0 epithelial cell differentiation 0.046 0.05 -9999.0 0.0 -0.287 5.0 5.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.008 0.052 0.273 1.0 -9999.0 0.0 1.0 EGFR 0.011 0.092 -9999.0 0.0 -0.533 8.0 8.0 EPHA2 0.025 0.033 -9999.0 0.0 -0.533 1.0 1.0 MYO6 -0.015 0.048 -9999.0 0.0 -0.33 5.0 5.0 CTNNB1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.052 0.163 -9999.0 0.0 -0.493 33.0 33.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.039 -9999.0 0.0 -0.274 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.036 0.083 -9999.0 0.0 -0.279 29.0 29.0 EGF -0.006 0.12 -9999.0 0.0 -0.533 14.0 14.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.015 0.098 -9999.0 0.0 -0.442 10.0 10.0 cortical microtubule organization 0.046 0.05 -9999.0 0.0 -0.287 5.0 5.0 GO:0000145 -0.014 0.037 -9999.0 0.0 -0.262 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.051 0.052 -9999.0 0.0 -0.29 5.0 5.0 MLLT4 0.024 0.033 -9999.0 0.0 -0.533 1.0 1.0 ARF6/GDP -0.022 0.033 -9999.0 0.0 -0.258 1.0 1.0 ARF6 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.034 -9999.0 0.0 -0.308 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.0 0.036 -9999.0 0.0 -0.274 1.0 1.0 PVRL2 0.024 0.033 -9999.0 0.0 -0.533 1.0 1.0 ZYX -0.014 0.04 -9999.0 0.0 -0.278 5.0 5.0 ARF6/GTP 0.065 0.036 -9999.0 0.0 -0.289 1.0 1.0 CDH1 0.015 0.073 -9999.0 0.0 -0.533 5.0 5.0 EGFR/EGFR/EGF/EGF 0.014 0.093 -9999.0 0.0 -0.272 26.0 26.0 RhoA/GDP 0.047 0.049 -9999.0 0.0 -0.276 5.0 5.0 actin cytoskeleton organization -0.017 0.049 -9999.0 0.0 -0.326 6.0 6.0 IGF-1R heterotetramer 0.007 0.102 -9999.0 0.0 -0.532 10.0 10.0 GIT1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.007 0.102 -9999.0 0.0 -0.533 10.0 10.0 IGF1 0.007 0.097 -9999.0 0.0 -0.533 9.0 9.0 DIAPH1 0.042 0.094 -9999.0 0.0 -0.539 2.0 2.0 Wnt receptor signaling pathway -0.046 0.05 0.287 5.0 -9999.0 0.0 5.0 RHOA 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.022 0.033 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.05 -9999.0 0.0 -0.334 6.0 6.0 EFNA1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.013 0.036 -9999.0 0.0 -0.268 3.0 3.0 Ephrin A1/EPHA2 0.038 0.048 -9999.0 0.0 -0.273 5.0 5.0 SEC6/SEC8 -0.02 0.041 -9999.0 0.0 -0.274 7.0 7.0 MGAT3 -0.036 0.084 -9999.0 0.0 -0.283 29.0 29.0 HGF/MET 0.013 0.099 -9999.0 0.0 -0.282 28.0 28.0 HGF 0.017 0.073 -9999.0 0.0 -0.533 5.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.017 0.039 -9999.0 0.0 -0.249 5.0 5.0 actin cable formation 0.03 0.071 0.318 5.0 -9999.0 0.0 5.0 KIAA1543 -0.016 0.045 -9999.0 0.0 -0.278 7.0 7.0 KIFC3 -0.015 0.037 -9999.0 0.0 -0.278 5.0 5.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.039 -9999.0 0.0 -0.275 5.0 5.0 NCK1/GIT1 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.046 0.05 -9999.0 0.0 -0.287 5.0 5.0 EXOC4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.014 0.04 -9999.0 0.0 -0.278 5.0 5.0 PIP5K1C -0.014 0.039 -9999.0 0.0 -0.278 5.0 5.0 LIMA1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.005 0.062 0.294 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.03 0.12 -9999.0 0.0 -0.695 7.0 7.0 IGF-1R heterotetramer/IGF1 0.017 0.094 -9999.0 0.0 -0.29 23.0 23.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.032 0.039 -9999.0 0.0 -0.391 2.0 2.0 MET -0.013 0.141 -9999.0 0.0 -0.533 20.0 20.0 PLEKHA7 -0.016 0.047 -9999.0 0.0 -0.291 7.0 7.0 mol:GTP 0.057 0.033 -9999.0 0.0 -0.306 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.011 0.089 0.322 6.0 -0.328 1.0 7.0 cortical actin cytoskeleton stabilization 0.017 0.039 -9999.0 0.0 -0.247 5.0 5.0 regulation of cell-cell adhesion -0.017 0.049 -9999.0 0.0 -0.326 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.017 0.039 -9999.0 0.0 -0.249 5.0 5.0