Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	46.0	374.0	8.0	-0.067	0.046	1000.0	-1000.0	-0.003	-1000.0
IL4-mediated signaling events	36.0	3360.0	91.0	-0.644	0.535	1000.0	-1000.0	-0.163	-1000.0
FOXA2 and FOXA3 transcription factor networks	34.0	1591.0	46.0	-0.402	0.028	1000.0	-1000.0	-0.096	-1000.0
Signaling events regulated by Ret tyrosine kinase	34.0	2867.0	82.0	-0.098	0.028	1000.0	-1000.0	-0.05	-1000.0
IL23-mediated signaling events	31.0	1904.0	60.0	-0.389	0.027	1000.0	-1000.0	-0.13	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	29.0	1019.0	34.0	-0.062	0.028	1000.0	-1000.0	-0.029	-1000.0
Syndecan-1-mediated signaling events	28.0	966.0	34.0	-0.107	0.027	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	28.0	199.0	7.0	-0.061	0.045	1000.0	-1000.0	-0.006	-1000.0
Wnt signaling	26.0	182.0	7.0	-0.089	0.002	1000.0	-1000.0	-0.017	-1000.0
TCR signaling in naïve CD8+ T cells	24.0	2298.0	93.0	-0.125	0.039	1000.0	-1000.0	-0.051	-1000.0
Noncanonical Wnt signaling pathway	23.0	621.0	26.0	-0.093	0.027	1000.0	-1000.0	-0.04	-1000.0
Ephrin B reverse signaling	23.0	1124.0	48.0	-0.131	0.037	1000.0	-1000.0	-0.033	-1000.0
Syndecan-4-mediated signaling events	23.0	1589.0	67.0	-0.106	0.037	1000.0	-1000.0	-0.032	-1000.0
Caspase cascade in apoptosis	21.0	1604.0	74.0	-0.146	0.068	1000.0	-1000.0	-0.047	-1000.0
Endothelins	21.0	2089.0	96.0	-0.097	0.029	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	21.0	1449.0	68.0	-0.202	0.096	1000.0	-1000.0	-0.098	-1000.0
Thromboxane A2 receptor signaling	20.0	2122.0	105.0	-0.101	0.036	1000.0	-1000.0	-0.046	-1000.0
IL12-mediated signaling events	19.0	1691.0	87.0	-0.176	0.029	1000.0	-1000.0	-0.088	-1000.0
Signaling events mediated by the Hedgehog family	19.0	1009.0	52.0	-0.1	0.049	1000.0	-1000.0	-0.033	-1000.0
amb2 Integrin signaling	19.0	1611.0	82.0	-0.107	0.036	1000.0	-1000.0	-0.039	-1000.0
Visual signal transduction: Cones	18.0	703.0	38.0	-0.08	0.028	1000.0	-1000.0	-0.011	-1000.0
HIF-1-alpha transcription factor network	17.0	1322.0	76.0	-0.141	0.045	1000.0	-1000.0	-0.097	-1000.0
Fc-epsilon receptor I signaling in mast cells	17.0	1722.0	97.0	-0.065	0.043	1000.0	-1000.0	-0.055	-1000.0
Reelin signaling pathway	17.0	955.0	56.0	-0.082	0.072	1000.0	-1000.0	-0.038	-1000.0
Glucocorticoid receptor regulatory network	16.0	1936.0	114.0	-0.302	0.17	1000.0	-1000.0	-0.067	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	16.0	853.0	52.0	-0.114	0.052	1000.0	-1000.0	-0.052	-1000.0
Visual signal transduction: Rods	16.0	835.0	52.0	-0.063	0.03	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	15.0	1341.0	85.0	-0.055	0.164	1000.0	-1000.0	-0.065	-1000.0
LPA receptor mediated events	15.0	1554.0	102.0	-0.065	0.031	1000.0	-1000.0	-0.055	-1000.0
BCR signaling pathway	15.0	1494.0	99.0	-0.118	0.037	1000.0	-1000.0	-0.059	-1000.0
p75(NTR)-mediated signaling	14.0	1867.0	125.0	-0.077	0.066	1000.0	-1000.0	-0.068	-1000.0
BMP receptor signaling	14.0	1204.0	81.0	-0.12	0.047	1000.0	-1000.0	-0.044	-1000.0
Glypican 1 network	14.0	714.0	48.0	-0.07	0.048	1000.0	-1000.0	-0.03	-1000.0
FAS signaling pathway (CD95)	14.0	659.0	47.0	-0.097	0.039	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	13.0	908.0	65.0	-0.084	0.039	1000.0	-1000.0	-0.058	-1000.0
Retinoic acid receptors-mediated signaling	13.0	791.0	58.0	-0.104	0.048	1000.0	-1000.0	-0.04	-1000.0
Effects of Botulinum toxin	13.0	358.0	26.0	-0.067	0.027	1000.0	-1000.0	-0.008	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	410.0	31.0	-0.091	0.027	1000.0	-1000.0	-0.035	-1000.0
Osteopontin-mediated events	12.0	461.0	38.0	-0.062	0.033	1000.0	-1000.0	-0.038	-1000.0
Nongenotropic Androgen signaling	12.0	629.0	52.0	-0.043	0.037	1000.0	-1000.0	-0.041	-1000.0
IL27-mediated signaling events	12.0	627.0	51.0	-0.094	0.042	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	12.0	1001.0	78.0	-0.068	0.028	1000.0	-1000.0	-0.043	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	11.0	992.0	85.0	-0.028	0.034	1000.0	-1000.0	-0.049	-1000.0
Plasma membrane estrogen receptor signaling	11.0	983.0	86.0	-0.053	0.043	1000.0	-1000.0	-0.051	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	11.0	1411.0	120.0	-0.093	0.071	1000.0	-1000.0	-0.045	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.003	0.003	1000.0	-1000.0	-0.013	-1000.0
LPA4-mediated signaling events	10.0	122.0	12.0	-0.052	0.013	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by PTP1B	10.0	781.0	76.0	-0.042	0.034	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	10.0	462.0	45.0	-0.054	0.066	1000.0	-1000.0	-0.048	-1000.0
Canonical Wnt signaling pathway	10.0	558.0	51.0	-0.11	0.15	1000.0	-1000.0	-0.05	-1000.0
EGFR-dependent Endothelin signaling events	10.0	229.0	21.0	-0.032	0.042	1000.0	-1000.0	-0.04	-1000.0
IGF1 pathway	10.0	603.0	57.0	-0.015	0.052	1000.0	-1000.0	-0.035	-1000.0
Coregulation of Androgen receptor activity	9.0	737.0	76.0	-0.106	0.051	1000.0	-1000.0	-0.022	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	523.0	54.0	-0.058	0.039	1000.0	-1000.0	-0.029	-1000.0
JNK signaling in the CD4+ TCR pathway	9.0	156.0	17.0	-0.014	0.031	1000.0	-1000.0	-0.031	-1000.0
Arf6 signaling events	9.0	599.0	62.0	-0.031	0.059	1000.0	-1000.0	-0.04	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	402.0	44.0	-0.053	0.036	1000.0	-1000.0	-0.039	-1000.0
IL6-mediated signaling events	9.0	687.0	75.0	-0.117	0.044	1000.0	-1000.0	-0.06	-1000.0
BARD1 signaling events	8.0	504.0	57.0	-0.036	0.063	1000.0	-1000.0	-0.039	-1000.0
Syndecan-2-mediated signaling events	8.0	554.0	69.0	-0.03	0.04	1000.0	-1000.0	-0.035	-1000.0
Cellular roles of Anthrax toxin	8.0	350.0	39.0	-0.061	0.027	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	8.0	457.0	55.0	0.002	0.063	1000.0	-1000.0	-0.042	-1000.0
Nectin adhesion pathway	8.0	566.0	63.0	-0.029	0.051	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class III	8.0	327.0	40.0	-0.075	0.053	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	8.0	419.0	49.0	-0.03	0.038	1000.0	-1000.0	-0.036	-1000.0
S1P1 pathway	8.0	315.0	36.0	-0.049	0.028	1000.0	-1000.0	-0.038	-1000.0
IL2 signaling events mediated by PI3K	8.0	471.0	58.0	-0.025	0.051	1000.0	-1000.0	-0.052	-1000.0
Integrins in angiogenesis	8.0	699.0	84.0	-0.053	0.049	1000.0	-1000.0	-0.046	-1000.0
Glypican 2 network	8.0	32.0	4.0	0.012	0.019	1000.0	-1000.0	0.011	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	290.0	33.0	-0.071	0.067	1000.0	-1000.0	-0.036	-1000.0
FOXM1 transcription factor network	8.0	412.0	51.0	-0.072	0.048	1000.0	-1000.0	-0.124	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1079.0	136.0	-0.168	0.071	1000.0	-1000.0	-0.047	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	473.0	61.0	-0.105	0.066	1000.0	-1000.0	-0.04	-1000.0
IFN-gamma pathway	7.0	508.0	68.0	-0.04	0.044	1000.0	-1000.0	-0.051	-1000.0
Ceramide signaling pathway	7.0	581.0	76.0	-0.035	0.07	1000.0	-1000.0	-0.033	-1000.0
Syndecan-3-mediated signaling events	7.0	261.0	35.0	-0.051	0.066	1000.0	-1000.0	-0.024	-1000.0
Angiopoietin receptor Tie2-mediated signaling	7.0	673.0	88.0	-0.035	0.047	1000.0	-1000.0	-0.084	-1000.0
Ras signaling in the CD4+ TCR pathway	7.0	135.0	17.0	-0.006	0.042	1000.0	-1000.0	-0.019	-1000.0
ErbB4 signaling events	6.0	449.0	69.0	-0.113	0.087	1000.0	-1000.0	-0.042	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	239.0	37.0	-0.027	0.059	1000.0	-1000.0	-0.03	-1000.0
IL1-mediated signaling events	6.0	418.0	62.0	-0.025	0.056	1000.0	-1000.0	-0.041	-1000.0
HIF-2-alpha transcription factor network	6.0	272.0	43.0	-0.054	0.056	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	6.0	340.0	54.0	-0.054	0.064	1000.0	-1000.0	-0.047	-1000.0
IL2 signaling events mediated by STAT5	6.0	153.0	22.0	-0.024	0.028	1000.0	-1000.0	-0.05	-1000.0
PDGFR-beta signaling pathway	6.0	648.0	97.0	-0.096	0.062	1000.0	-1000.0	-0.058	-1000.0
Regulation of Androgen receptor activity	6.0	472.0	70.0	-0.102	0.032	1000.0	-1000.0	-0.049	-1000.0
Ephrin A  reverse signaling	5.0	40.0	7.0	-0.002	0.019	1000.0	-1000.0	-0.008	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	25.0	5.0	0.014	0.033	1000.0	-1000.0	0.012	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	326.0	65.0	-0.171	0.055	1000.0	-1000.0	-0.042	-1000.0
TRAIL signaling pathway	5.0	265.0	48.0	-0.005	0.031	1000.0	-1000.0	-0.035	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	430.0	74.0	-0.052	0.065	1000.0	-1000.0	-0.064	-1000.0
Class I PI3K signaling events	5.0	365.0	73.0	-0.029	0.05	1000.0	-1000.0	-0.042	-1000.0
Regulation of Telomerase	5.0	531.0	102.0	-0.126	0.06	1000.0	-1000.0	-0.045	-1000.0
S1P3 pathway	5.0	210.0	42.0	-0.021	0.041	1000.0	-1000.0	-0.032	-1000.0
S1P4 pathway	5.0	132.0	25.0	-0.021	0.039	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	135.0	28.0	-0.017	0.038	1000.0	-1000.0	-0.026	-1000.0
Aurora A signaling	4.0	242.0	60.0	-0.023	0.059	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	4.0	414.0	85.0	-0.005	0.057	1000.0	-1000.0	-0.038	-1000.0
mTOR signaling pathway	4.0	264.0	53.0	-0.063	0.058	1000.0	-1000.0	-0.036	-1000.0
S1P5 pathway	4.0	72.0	17.0	-0.013	0.028	1000.0	-1000.0	-0.021	-1000.0
FoxO family signaling	4.0	263.0	64.0	-0.095	0.047	1000.0	-1000.0	-0.065	-1000.0
TCGA08_rtk_signaling	4.0	110.0	26.0	-0.035	0.06	1000.0	-1000.0	-0.005	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	378.0	76.0	-0.044	0.055	1000.0	-1000.0	-0.052	-1000.0
Insulin Pathway	4.0	327.0	74.0	-0.023	0.068	1000.0	-1000.0	-0.047	-1000.0
Canonical NF-kappaB pathway	3.0	129.0	39.0	-0.03	0.054	1000.0	-1000.0	-0.036	-1000.0
Arf6 downstream pathway	3.0	144.0	43.0	-0.045	0.047	1000.0	-1000.0	-0.02	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	207.0	68.0	-0.035	0.05	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class I	3.0	381.0	104.0	-0.047	0.063	1000.0	-1000.0	-0.035	-1000.0
Signaling mediated by p38-gamma and p38-delta	3.0	49.0	15.0	-0.027	0.03	1000.0	-1000.0	-0.028	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	113.0	36.0	-0.043	0.046	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	3.0	140.0	43.0	-0.023	0.041	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling events	3.0	15.0	5.0	0.015	0.042	1000.0	-1000.0	0.008	-1000.0
Aurora B signaling	3.0	220.0	67.0	-0.046	0.061	1000.0	-1000.0	-0.038	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	0.007	0.026	1000.0	-1000.0	-0.011	-1000.0
Aurora C signaling	2.0	18.0	7.0	0.0	0.039	1000.0	-1000.0	-0.015	-1000.0
Insulin-mediated glucose transport	2.0	67.0	32.0	-0.014	0.053	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	231.0	83.0	-0.065	0.056	1000.0	-1000.0	-0.047	-1000.0
Rapid glucocorticoid signaling	2.0	57.0	20.0	-0.003	0.035	1000.0	-1000.0	-0.003	-1000.0
Signaling events mediated by PRL	2.0	75.0	34.0	-0.034	0.039	1000.0	-1000.0	-0.036	-1000.0
p38 MAPK signaling pathway	2.0	115.0	44.0	-0.028	0.054	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by HDAC Class II	1.0	134.0	75.0	-0.029	0.07	1000.0	-1000.0	-0.035	-1000.0
Circadian rhythm pathway	1.0	38.0	22.0	-0.007	0.044	1000.0	-1000.0	-0.044	-1000.0
Atypical NF-kappaB pathway	1.0	39.0	31.0	0.0	0.031	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	156.0	125.0	-0.006	0.068	1000.0	-1000.0	-0.046	-1000.0
Arf6 trafficking events	1.0	98.0	71.0	-0.047	0.05	1000.0	-1000.0	-0.029	-1000.0
VEGFR1 specific signals	1.0	92.0	56.0	-0.019	0.055	1000.0	-1000.0	-0.043	-1000.0
Arf1 pathway	1.0	57.0	54.0	-0.002	0.035	1000.0	-1000.0	-0.019	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	0.01	0.051	1000.0	-1000.0	-0.028	-1000.0
PDGFR-alpha signaling pathway	0.0	43.0	44.0	-0.039	0.064	1000.0	-1000.0	-0.043	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.0	0.062	1000.0	-1000.0	-0.035	-1000.0
Alternative NF-kappaB pathway	0.0	7.0	13.0	0.0	0.072	1000.0	-1000.0	0.0	-1000.0
Total	1331	80569	7203	-8.96542231793	6.82012527444	131000	-131000	-5.31322278984	-131000