Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.049 0.23 -9999.0 0.0 -0.58 10.0 10.0 IHH -0.033 0.159 -9999.0 0.0 -0.59 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.091 0.151 -9999.0 0.0 -0.278 27.0 27.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.091 0.15 0.276 27.0 -9999.0 0.0 27.0 SMO/beta Arrestin2 -0.056 0.203 -9999.0 0.0 -0.603 6.0 6.0 SMO -0.065 0.214 -9999.0 0.0 -0.641 6.0 6.0 AKT1 -0.016 0.104 -9999.0 0.0 -0.357 2.0 2.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.076 -9999.0 0.0 -0.45 2.0 2.0 ADRBK1 0.005 0.054 -9999.0 0.0 -0.45 1.0 1.0 heart looping -0.063 0.209 -9999.0 0.0 -0.628 6.0 6.0 STIL -0.026 0.177 -9999.0 0.0 -0.609 4.0 4.0 DHH N/PTCH2 -0.044 0.147 -9999.0 0.0 -0.384 11.0 11.0 DHH N/PTCH1 -0.059 0.183 -9999.0 0.0 -0.582 4.0 4.0 PIK3CA 0.004 0.063 -9999.0 0.0 -0.529 1.0 1.0 DHH -0.054 0.173 -9999.0 0.0 -0.511 9.0 9.0 PTHLH -0.091 0.333 -9999.0 0.0 -0.895 10.0 10.0 determination of left/right symmetry -0.063 0.209 -9999.0 0.0 -0.628 6.0 6.0 PIK3R1 0.005 0.054 -9999.0 0.0 -0.45 1.0 1.0 skeletal system development -0.09 0.329 -9999.0 0.0 -0.883 10.0 10.0 IHH N/Hhip -0.085 0.21 -9999.0 0.0 -0.455 16.0 16.0 DHH N/Hhip -0.102 0.192 -9999.0 0.0 -0.39 21.0 21.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.063 0.209 -9999.0 0.0 -0.628 6.0 6.0 pancreas development -0.089 0.205 -9999.0 0.0 -0.505 14.0 14.0 HHAT 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.007 0.06 -9999.0 0.0 -0.345 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.148 0.234 -9999.0 0.0 -0.488 23.0 23.0 somite specification -0.063 0.209 -9999.0 0.0 -0.628 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.033 0.187 -9999.0 0.0 -0.65 4.0 4.0 SHH Np/Cholesterol/PTCH2 -0.014 0.104 -9999.0 0.0 -0.292 8.0 8.0 SHH Np/Cholesterol/Megalin -0.018 0.091 -9999.0 0.0 -0.257 9.0 9.0 SHH -0.012 0.104 -9999.0 0.0 -0.356 6.0 6.0 catabolic process -0.03 0.177 -9999.0 0.0 -0.66 3.0 3.0 SMO/Vitamin D3 -0.056 0.209 -9999.0 0.0 -0.621 6.0 6.0 SHH Np/Cholesterol/Hhip -0.059 0.146 -9999.0 0.0 -0.298 18.0 18.0 LRP2 -0.014 0.091 -9999.0 0.0 -0.45 3.0 3.0 receptor-mediated endocytosis -0.051 0.202 -9999.0 0.0 -0.728 4.0 4.0 SHH Np/Cholesterol/BOC -0.01 0.088 -9999.0 0.0 -0.257 8.0 8.0 SHH Np/Cholesterol/CDO -0.011 0.101 -9999.0 0.0 -0.309 7.0 7.0 mesenchymal cell differentiation 0.059 0.145 0.296 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.031 0.189 -9999.0 0.0 -0.654 4.0 4.0 IHH N/PTCH2 -0.024 0.135 -9999.0 0.0 -0.427 6.0 6.0 CDON -0.003 0.089 -9999.0 0.0 -0.529 2.0 2.0 IHH N/PTCH1 -0.03 0.18 -9999.0 0.0 -0.67 3.0 3.0 Megalin/LRPAP1 -0.001 0.065 -9999.0 0.0 -0.312 3.0 3.0 PTCH2 -0.009 0.098 -9999.0 0.0 -0.476 3.0 3.0 SHH Np/Cholesterol -0.011 0.079 -9999.0 0.0 -0.273 6.0 6.0 PTCH1 -0.03 0.178 -9999.0 0.0 -0.664 3.0 3.0 HHIP -0.089 0.206 -9999.0 0.0 -0.506 14.0 14.0