Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	16.0	116.0	7.0	-0.14	0.004	1000.0	-1000.0	-0.012	-1000.0
IL4-mediated signaling events	12.0	1115.0	91.0	-0.686	0.603	1000.0	-1000.0	-0.165	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	476.0	44.0	-0.193	0.012	1000.0	-1000.0	-0.044	-1000.0
Syndecan-4-mediated signaling events	9.0	609.0	67.0	-0.174	0.025	1000.0	-1000.0	-0.08	-1000.0
IL23-mediated signaling events	9.0	545.0	60.0	-0.432	0.012	1000.0	-1000.0	-0.184	-1000.0
FOXA2 and FOXA3 transcription factor networks	8.0	382.0	46.0	-0.503	0.018	1000.0	-1000.0	-0.113	-1000.0
Endothelins	8.0	778.0	96.0	-0.166	0.012	1000.0	-1000.0	-0.078	-1000.0
IL12-mediated signaling events	7.0	628.0	87.0	-0.323	0.079	1000.0	-1000.0	-0.139	-1000.0
Signaling events mediated by the Hedgehog family	7.0	374.0	52.0	-0.148	0.091	1000.0	-1000.0	-0.054	-1000.0
TCGA08_p53	7.0	55.0	7.0	-0.055	0.027	1000.0	-1000.0	-0.02	-1000.0
Wnt signaling	7.0	49.0	7.0	-0.089	0.004	1000.0	-1000.0	-0.027	-1000.0
Syndecan-1-mediated signaling events	6.0	215.0	34.0	-0.152	0.012	1000.0	-1000.0	-0.047	-1000.0
HIF-1-alpha transcription factor network	6.0	517.0	76.0	-0.323	0.018	1000.0	-1000.0	-0.164	-1000.0
p75(NTR)-mediated signaling	6.0	754.0	125.0	-0.157	0.03	1000.0	-1000.0	-0.083	-1000.0
Glypican 1 network	6.0	334.0	48.0	-0.172	0.015	1000.0	-1000.0	-0.034	-1000.0
amb2 Integrin signaling	6.0	497.0	82.0	-0.132	0.012	1000.0	-1000.0	-0.076	-1000.0
BCR signaling pathway	6.0	635.0	99.0	-0.161	0.02	1000.0	-1000.0	-0.082	-1000.0
EGFR-dependent Endothelin signaling events	6.0	127.0	21.0	-0.147	0.012	1000.0	-1000.0	-0.06	-1000.0
Syndecan-2-mediated signaling events	5.0	360.0	69.0	-0.147	0.02	1000.0	-1000.0	-0.035	-1000.0
BMP receptor signaling	5.0	422.0	81.0	-0.165	0.022	1000.0	-1000.0	-0.089	-1000.0
Glucocorticoid receptor regulatory network	5.0	630.0	114.0	-0.381	0.233	1000.0	-1000.0	-0.055	-1000.0
Ephrin B reverse signaling	5.0	250.0	48.0	-0.142	0.048	1000.0	-1000.0	-0.06	-1000.0
TCR signaling in naïve CD8+ T cells	5.0	518.0	93.0	-0.118	0.012	1000.0	-1000.0	-0.077	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	369.0	68.0	-0.301	0.083	1000.0	-1000.0	-0.113	-1000.0
TCGA08_retinoblastoma	5.0	47.0	8.0	-0.068	0.02	1000.0	-1000.0	-0.013	-1000.0
Caspase cascade in apoptosis	4.0	303.0	74.0	-0.094	0.068	1000.0	-1000.0	-0.041	-1000.0
Thromboxane A2 receptor signaling	4.0	475.0	105.0	-0.147	0.043	1000.0	-1000.0	-0.062	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	450.0	97.0	-0.133	0.031	1000.0	-1000.0	-0.08	-1000.0
Reelin signaling pathway	4.0	251.0	56.0	-0.087	0.02	1000.0	-1000.0	-0.067	-1000.0
Retinoic acid receptors-mediated signaling	4.0	236.0	58.0	-0.166	0.012	1000.0	-1000.0	-0.063	-1000.0
Effects of Botulinum toxin	4.0	129.0	26.0	-0.13	0.012	1000.0	-1000.0	-0.05	-1000.0
Calcium signaling in the CD4+ TCR pathway	4.0	148.0	31.0	-0.129	0.012	1000.0	-1000.0	-0.045	-1000.0
LPA receptor mediated events	4.0	478.0	102.0	-0.152	0.021	1000.0	-1000.0	-0.08	-1000.0
Plasma membrane estrogen receptor signaling	4.0	376.0	86.0	-0.067	0.055	1000.0	-1000.0	-0.083	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	4.0	598.0	120.0	-0.2	0.132	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	4.0	339.0	78.0	-0.097	0.067	1000.0	-1000.0	-0.083	-1000.0
Osteopontin-mediated events	3.0	137.0	38.0	-0.143	0.013	1000.0	-1000.0	-0.091	-1000.0
Noncanonical Wnt signaling pathway	3.0	95.0	26.0	-0.089	0.012	1000.0	-1000.0	-0.042	-1000.0
Cellular roles of Anthrax toxin	3.0	148.0	39.0	-0.044	0.012	1000.0	-1000.0	-0.029	-1000.0
Arf6 signaling events	3.0	201.0	62.0	-0.147	0.023	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PTP1B	3.0	233.0	76.0	-0.147	0.018	1000.0	-1000.0	-0.08	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	239.0	61.0	-0.16	0.061	1000.0	-1000.0	-0.065	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	254.0	82.0	-0.106	0.012	1000.0	-1000.0	-0.077	-1000.0
FAS signaling pathway (CD95)	3.0	181.0	47.0	-0.139	0.015	1000.0	-1000.0	-0.038	-1000.0
Canonical Wnt signaling pathway	3.0	198.0	51.0	-0.161	0.089	1000.0	-1000.0	-0.058	-1000.0
EPHB forward signaling	3.0	303.0	85.0	-0.14	0.063	1000.0	-1000.0	-0.077	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.008	-0.001	1000.0	-1000.0	-0.015	-1000.0
IL27-mediated signaling events	3.0	175.0	51.0	-0.282	0.013	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by PRL	3.0	119.0	34.0	-0.047	0.039	1000.0	-1000.0	-0.031	-1000.0
LPA4-mediated signaling events	2.0	31.0	12.0	-0.029	0.016	1000.0	-1000.0	-0.027	-1000.0
Coregulation of Androgen receptor activity	2.0	175.0	76.0	-0.175	0.045	1000.0	-1000.0	-0.027	-1000.0
ErbB4 signaling events	2.0	170.0	69.0	-0.118	0.035	1000.0	-1000.0	-0.088	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	66.0	28.0	-0.058	0.019	1000.0	-1000.0	-0.039	-1000.0
Visual signal transduction: Cones	2.0	77.0	38.0	-0.023	0.011	1000.0	-1000.0	-0.023	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	108.0	54.0	-0.083	0.023	1000.0	-1000.0	-0.084	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	146.0	65.0	-0.085	0.029	1000.0	-1000.0	-0.063	-1000.0
Nectin adhesion pathway	2.0	168.0	63.0	-0.043	0.02	1000.0	-1000.0	-0.071	-1000.0
Signaling events mediated by HDAC Class III	2.0	92.0	40.0	-0.091	0.022	1000.0	-1000.0	-0.026	-1000.0
TRAIL signaling pathway	2.0	118.0	48.0	-0.043	0.025	1000.0	-1000.0	-0.058	-1000.0
IL1-mediated signaling events	2.0	170.0	62.0	-0.085	0.049	1000.0	-1000.0	-0.083	-1000.0
S1P1 pathway	2.0	80.0	36.0	-0.108	0.012	1000.0	-1000.0	-0.068	-1000.0
Syndecan-3-mediated signaling events	2.0	78.0	35.0	-0.147	0.027	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	2.0	123.0	58.0	-0.053	0.022	1000.0	-1000.0	-0.08	-1000.0
Integrins in angiogenesis	2.0	223.0	84.0	-0.173	0.026	1000.0	-1000.0	-0.082	-1000.0
Nongenotropic Androgen signaling	2.0	116.0	52.0	-0.058	0.02	1000.0	-1000.0	-0.052	-1000.0
IL6-mediated signaling events	2.0	156.0	75.0	-0.119	0.034	1000.0	-1000.0	-0.067	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	71.0	27.0	-0.041	0.012	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by STAT5	2.0	53.0	22.0	-0.061	0.021	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events	2.0	212.0	73.0	-0.057	0.019	1000.0	-1000.0	-0.057	-1000.0
Regulation of Telomerase	2.0	216.0	102.0	-0.174	0.029	1000.0	-1000.0	-0.1	-1000.0
S1P3 pathway	2.0	93.0	42.0	-0.059	0.019	1000.0	-1000.0	-0.04	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	237.0	88.0	-0.153	0.073	1000.0	-1000.0	-0.091	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.003	-1000.0	1000.0	-1000.0	-0.01	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	39.0	17.0	-0.046	0.011	1000.0	-1000.0	-0.041	-1000.0
ErbB2/ErbB3 signaling events	1.0	109.0	65.0	-0.041	0.039	1000.0	-1000.0	-0.064	-1000.0
Regulation of nuclear SMAD2/3 signaling	1.0	188.0	136.0	-0.056	0.048	1000.0	-1000.0	-0.056	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	65.0	34.0	-0.041	0.012	1000.0	-1000.0	-0.041	-1000.0
Canonical NF-kappaB pathway	1.0	45.0	39.0	-0.025	0.047	1000.0	-1000.0	-0.075	-1000.0
Signaling events mediated by HDAC Class II	1.0	113.0	75.0	-0.044	0.031	1000.0	-1000.0	-0.037	-1000.0
BARD1 signaling events	1.0	61.0	57.0	-0.056	0.048	1000.0	-1000.0	-0.058	-1000.0
PLK2 and PLK4 events	1.0	4.0	3.0	-0.001	0.012	1000.0	-1000.0	-0.01	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	32.0	17.0	-0.025	0.014	1000.0	-1000.0	-0.038	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.017	0.017	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	118.0	85.0	-0.048	0.037	1000.0	-1000.0	-0.064	-1000.0
Aurora A signaling	1.0	60.0	60.0	-0.053	0.032	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	1.0	65.0	55.0	-0.048	0.032	1000.0	-1000.0	-0.082	-1000.0
PDGFR-alpha signaling pathway	1.0	73.0	44.0	-0.058	0.023	1000.0	-1000.0	-0.06	-1000.0
mTOR signaling pathway	1.0	60.0	53.0	-0.014	0.02	1000.0	-1000.0	-0.057	-1000.0
IFN-gamma pathway	1.0	95.0	68.0	-0.048	0.033	1000.0	-1000.0	-0.089	-1000.0
Ceramide signaling pathway	1.0	118.0	76.0	-0.147	0.047	1000.0	-1000.0	-0.043	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	40.0	37.0	-0.085	0.033	1000.0	-1000.0	-0.049	-1000.0
S1P5 pathway	1.0	31.0	17.0	-0.058	0.017	1000.0	-1000.0	-0.037	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	75.0	52.0	-0.074	0.031	1000.0	-1000.0	-0.043	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	115.0	83.0	-0.165	0.044	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by HDAC Class I	1.0	111.0	104.0	-0.041	0.034	1000.0	-1000.0	-0.062	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	16.0	15.0	-0.027	0.021	1000.0	-1000.0	-0.025	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	1.0	51.0	45.0	-0.048	0.044	1000.0	-1000.0	-0.081	-1000.0
Regulation of p38-alpha and p38-beta	1.0	59.0	54.0	-0.057	0.03	1000.0	-1000.0	-0.06	-1000.0
TCGA08_rtk_signaling	1.0	47.0	26.0	-0.043	0.025	1000.0	-1000.0	-0.02	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	1.0	92.0	74.0	-0.147	0.042	1000.0	-1000.0	-0.08	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	109.0	76.0	-0.036	0.028	1000.0	-1000.0	-0.074	-1000.0
Insulin Pathway	1.0	132.0	74.0	-0.138	0.027	1000.0	-1000.0	-0.075	-1000.0
VEGFR1 specific signals	1.0	60.0	56.0	-0.041	0.023	1000.0	-1000.0	-0.052	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	54.0	33.0	-0.076	0.035	1000.0	-1000.0	-0.035	-1000.0
PDGFR-beta signaling pathway	1.0	165.0	97.0	-0.052	0.028	1000.0	-1000.0	-0.073	-1000.0
Visual signal transduction: Rods	1.0	95.0	52.0	-0.06	0.017	1000.0	-1000.0	-0.064	-1000.0
FOXM1 transcription factor network	1.0	68.0	51.0	-0.143	0.035	1000.0	-1000.0	-0.193	-1000.0
S1P4 pathway	1.0	44.0	25.0	-0.058	0.019	1000.0	-1000.0	-0.037	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	-0.003	0.014	1000.0	-1000.0	-0.021	-1000.0
p38 MAPK signaling pathway	1.0	45.0	44.0	-0.023	0.022	1000.0	-1000.0	-0.069	-1000.0
Regulation of Androgen receptor activity	1.0	122.0	70.0	-0.245	0.039	1000.0	-1000.0	-0.063	-1000.0
Aurora B signaling	1.0	94.0	67.0	-0.103	0.028	1000.0	-1000.0	-0.068	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	0.004	0.033	1000.0	-1000.0	-0.047	-1000.0
Circadian rhythm pathway	0.0	8.0	22.0	-0.012	0.038	1000.0	-1000.0	-0.05	-1000.0
Arf6 downstream pathway	0.0	11.0	43.0	-0.024	0.025	1000.0	-1000.0	-0.034	-1000.0
Aurora C signaling	0.0	6.0	7.0	-0.01	0.012	1000.0	-1000.0	-0.027	-1000.0
PLK1 signaling events	0.0	64.0	85.0	-0.026	0.029	1000.0	-1000.0	-0.041	-1000.0
Insulin-mediated glucose transport	0.0	20.0	32.0	-0.018	0.03	1000.0	-1000.0	-0.04	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	32.0	68.0	-0.029	0.037	1000.0	-1000.0	-0.048	-1000.0
ceramide signaling pathway	0.0	32.0	49.0	-0.024	0.028	1000.0	-1000.0	-0.046	-1000.0
HIF-2-alpha transcription factor network	0.0	37.0	43.0	-0.039	0.048	1000.0	-1000.0	-0.077	-1000.0
FoxO family signaling	0.0	28.0	64.0	-0.05	0.108	1000.0	-1000.0	-0.077	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	20.0	36.0	-0.033	0.035	1000.0	-1000.0	-0.065	-1000.0
Atypical NF-kappaB pathway	0.0	10.0	31.0	-0.031	0.029	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	95.0	125.0	-0.044	0.056	1000.0	-1000.0	-0.091	-1000.0
Arf6 trafficking events	0.0	33.0	71.0	-0.039	0.029	1000.0	-1000.0	-0.068	-1000.0
IGF1 pathway	0.0	40.0	57.0	-0.022	0.029	1000.0	-1000.0	-0.079	-1000.0
Rapid glucocorticoid signaling	0.0	11.0	20.0	-0.008	0.012	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in keratinocytes	0.0	19.0	43.0	-0.027	0.032	1000.0	-1000.0	-0.055	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.022	0.028	1000.0	-1000.0	-0.031	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.035	1000.0	-1000.0	-0.029	-1000.0
Total	348	23233	7203	-13.4779970344	-995.301052343	131000	-131000	-7.89500491313	-131000