Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.04 0.17 -9999.0 0.0 -0.525 7.0 7.0 IHH -0.003 0.123 -9999.0 0.0 -0.464 4.0 4.0 SHH Np/Cholesterol/GAS1 -0.016 0.104 -9999.0 0.0 -0.22 14.0 14.0 LRPAP1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.016 0.103 0.219 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.024 0.164 -9999.0 0.0 -0.465 5.0 5.0 SMO -0.046 0.162 -9999.0 0.0 -0.493 5.0 5.0 AKT1 -0.043 0.18 -9999.0 0.0 -0.603 5.0 5.0 ARRB2 0.025 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.045 0.16 -9999.0 0.0 -0.486 5.0 5.0 STIL -0.023 0.135 0.344 1.0 -0.468 3.0 4.0 DHH N/PTCH2 0.02 0.094 -9999.0 0.0 -0.282 6.0 6.0 DHH N/PTCH1 -0.019 0.142 -9999.0 0.0 -0.317 10.0 10.0 PIK3CA 0.026 0.05 -9999.0 0.0 -0.394 1.0 1.0 DHH 0.002 0.11 -9999.0 0.0 -0.394 5.0 5.0 PTHLH -0.081 0.272 -9999.0 0.0 -0.869 7.0 7.0 determination of left/right symmetry -0.045 0.16 -9999.0 0.0 -0.486 5.0 5.0 PIK3R1 0.031 0.012 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.08 0.269 -9999.0 0.0 -0.858 7.0 7.0 IHH N/Hhip -0.019 0.161 -9999.0 0.0 -0.374 11.0 11.0 DHH N/Hhip -0.021 0.143 -9999.0 0.0 -0.301 14.0 14.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.045 0.16 -9999.0 0.0 -0.486 5.0 5.0 pancreas development -0.024 0.151 -9999.0 0.0 -0.393 10.0 10.0 HHAT 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.041 0.04 -9999.0 0.0 -0.282 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.02 0.163 -9999.0 0.0 -0.394 11.0 11.0 somite specification -0.045 0.16 -9999.0 0.0 -0.486 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.02 0.132 -9999.0 0.0 -0.317 10.0 10.0 SHH Np/Cholesterol/PTCH2 0.014 0.065 -9999.0 0.0 -0.274 3.0 3.0 SHH Np/Cholesterol/Megalin 0.014 0.051 -9999.0 0.0 -0.212 3.0 3.0 SHH -0.021 0.055 0.243 1.0 -0.283 2.0 3.0 catabolic process -0.02 0.131 -9999.0 0.0 -0.329 10.0 10.0 SMO/Vitamin D3 -0.04 0.153 -9999.0 0.0 -0.394 9.0 9.0 SHH Np/Cholesterol/Hhip -0.015 0.105 -9999.0 0.0 -0.249 11.0 11.0 LRP2 0.031 0.018 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.044 0.151 -9999.0 0.0 -0.527 4.0 4.0 SHH Np/Cholesterol/BOC 0.016 0.05 -9999.0 0.0 -0.211 3.0 3.0 SHH Np/Cholesterol/CDO 0.014 0.049 -9999.0 0.0 -0.211 3.0 3.0 mesenchymal cell differentiation 0.015 0.105 0.247 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.014 0.143 0.365 1.0 -0.328 9.0 10.0 IHH N/PTCH2 0.02 0.1 -9999.0 0.0 -0.336 4.0 4.0 CDON 0.024 0.05 -9999.0 0.0 -0.394 1.0 1.0 IHH N/PTCH1 -0.009 0.137 -9999.0 0.0 -0.331 10.0 10.0 Megalin/LRPAP1 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.028 0.052 -9999.0 0.0 -0.394 1.0 1.0 SHH Np/Cholesterol 0.005 0.045 -9999.0 0.0 -0.206 3.0 3.0 PTCH1 -0.02 0.132 -9999.0 0.0 -0.33 10.0 10.0 HHIP -0.024 0.151 -9999.0 0.0 -0.394 10.0 10.0