Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.001 0.086 -9999.0 0.0 -0.287 5.0 5.0 epithelial cell differentiation 0.055 0.049 -9999.0 0.0 -0.208 2.0 2.0 CYFIP2 0.019 0.07 -9999.0 0.0 -0.394 2.0 2.0 ENAH -0.037 0.046 -9999.0 0.0 -0.288 1.0 1.0 EGFR 0.021 0.051 -9999.0 0.0 -0.394 1.0 1.0 EPHA2 0.032 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.026 0.039 0.17 1.0 -9999.0 0.0 1.0 CTNNB1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.052 0.053 -9999.0 0.0 -0.242 2.0 2.0 AQP5 -0.006 0.052 -9999.0 0.0 -0.306 1.0 1.0 CTNND1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.027 0.038 0.169 1.0 -9999.0 0.0 1.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.06 0.169 1.0 -9999.0 0.0 1.0 EGF -0.003 0.143 -9999.0 0.0 -0.394 8.0 8.0 NCKAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.018 0.097 -9999.0 0.0 -0.455 3.0 3.0 cortical microtubule organization 0.055 0.049 -9999.0 0.0 -0.208 2.0 2.0 GO:0000145 -0.026 0.036 0.153 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.051 -9999.0 0.0 -0.21 2.0 2.0 MLLT4 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.042 0.029 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.073 0.029 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.016 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.029 0.031 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.072 0.04 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.07 -9999.0 0.0 -0.394 2.0 2.0 EGFR/EGFR/EGF/EGF 0.014 0.105 -9999.0 0.0 -0.24 9.0 9.0 RhoA/GDP 0.055 0.049 -9999.0 0.0 -0.202 2.0 2.0 actin cytoskeleton organization -0.026 0.038 0.154 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.034 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DIAPH1 0.029 0.15 -9999.0 0.0 -0.583 4.0 4.0 Wnt receptor signaling pathway -0.055 0.049 0.208 2.0 -9999.0 0.0 2.0 RHOA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.043 0.029 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.026 0.039 0.155 1.0 -9999.0 0.0 1.0 EFNA1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.029 0.037 0.157 1.0 -9999.0 0.0 1.0 Ephrin A1/EPHA2 0.043 0.051 -9999.0 0.0 -0.203 2.0 2.0 SEC6/SEC8 -0.038 0.031 -9999.0 0.0 -0.202 2.0 2.0 MGAT3 -0.04 0.061 0.17 1.0 -9999.0 0.0 1.0 HGF/MET 0.043 0.057 -9999.0 0.0 -0.203 3.0 3.0 HGF 0.032 0.016 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.002 0.087 -9999.0 0.0 -0.289 5.0 5.0 actin cable formation -0.024 0.08 0.289 2.0 -0.254 1.0 3.0 KIAA1543 -0.027 0.036 0.154 1.0 -9999.0 0.0 1.0 KIFC3 -0.03 0.03 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.025 0.039 0.17 1.0 -9999.0 0.0 1.0 NCK1/GIT1 0.046 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.049 -9999.0 0.0 -0.208 2.0 2.0 EXOC4 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.03 0.03 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.027 0.038 0.17 1.0 -9999.0 0.0 1.0 LIMA1 0.006 0.098 -9999.0 0.0 -0.394 4.0 4.0 ABI1 0.031 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.032 0.06 0.277 1.0 -0.333 1.0 2.0 adherens junction assembly -0.012 0.052 0.264 1.0 -9999.0 0.0 1.0 IGF-1R heterotetramer/IGF1 0.047 0.049 -9999.0 0.0 -0.203 2.0 2.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.023 0.051 -9999.0 0.0 -0.394 1.0 1.0 PLEKHA7 -0.028 0.038 0.17 1.0 -9999.0 0.0 1.0 mol:GTP 0.07 0.028 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.024 0.071 0.307 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.001 0.086 -9999.0 0.0 -0.287 5.0 5.0 regulation of cell-cell adhesion -0.026 0.038 0.154 1.0 -9999.0 0.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.002 0.087 -9999.0 0.0 -0.289 5.0 5.0