E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.099 0.192 -9999.0 0.0 -0.388 67.0 67.0 KLHL20 -0.021 0.083 -9999.0 0.0 -0.212 10.0 10.0 CYFIP2 -0.012 0.099 -9999.0 0.0 -0.387 14.0 14.0 Rac1/GDP -0.038 0.119 -9999.0 0.0 -0.245 3.0 3.0 ENAH -0.103 0.194 -9999.0 0.0 -0.394 67.0 67.0 AP1M1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.012 0.018 -9999.0 0.0 -0.256 1.0 1.0 RAP1A 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.045 0.063 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.035 0.047 -9999.0 0.0 -0.154 14.0 14.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.062 0.126 -9999.0 0.0 -0.225 76.0 76.0 RAPGEF1 -0.077 0.169 -9999.0 0.0 -0.333 67.0 67.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.106 0.197 -9999.0 0.0 -0.404 67.0 67.0 CRK -0.088 0.181 -9999.0 0.0 -0.362 67.0 67.0 E-cadherin/gamma catenin/alpha catenin -0.066 0.127 -9999.0 0.0 -0.247 67.0 67.0 alphaE/beta7 Integrin -0.0 0.077 -9999.0 0.0 -0.283 15.0 15.0 IQGAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.024 0.025 -9999.0 0.0 -0.215 2.0 2.0 DLG1 -0.098 0.192 -9999.0 0.0 -0.388 67.0 67.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.033 0.046 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.01 0.041 -9999.0 0.0 -0.423 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.01 0.061 -9999.0 0.0 -0.214 15.0 15.0 PI3K -0.042 0.058 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.09 0.149 -9999.0 0.0 -0.299 68.0 68.0 TIAM1 -0.017 0.111 -9999.0 0.0 -0.413 16.0 16.0 E-cadherin(dimer)/Ca2+ -0.044 0.104 -9999.0 0.0 -0.196 67.0 67.0 AKT1 -0.024 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.012 0.029 -9999.0 0.0 -0.423 1.0 1.0 CDH1 -0.134 0.2 -9999.0 0.0 -0.396 80.0 80.0 RhoA/GDP -0.038 0.119 -9999.0 0.0 -0.242 3.0 3.0 actin cytoskeleton organization -0.014 0.063 -9999.0 0.0 -0.155 10.0 10.0 CDC42/GDP -0.038 0.119 -9999.0 0.0 -0.242 3.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.055 0.108 -9999.0 0.0 -0.214 67.0 67.0 ITGB7 -0.015 0.107 -9999.0 0.0 -0.412 15.0 15.0 RAC1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.047 0.112 -9999.0 0.0 -0.209 67.0 67.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.051 0.103 -9999.0 0.0 -0.201 67.0 67.0 mol:GDP -0.051 0.133 -9999.0 0.0 -0.252 64.0 64.0 CDC42/GTP/IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.005 0.054 -9999.0 0.0 -0.312 6.0 6.0 p120 catenin/RhoA/GDP -0.038 0.121 -9999.0 0.0 -0.245 3.0 3.0 RAC1/GTP/IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.008 0.048 -9999.0 0.0 -0.148 7.0 7.0 NME1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.102 0.193 -9999.0 0.0 -0.391 67.0 67.0 regulation of cell-cell adhesion -0.04 0.056 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.018 0.025 -9999.0 0.0 -0.11 1.0 1.0 Rap1/GTP -0.024 0.091 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.056 0.124 -9999.0 0.0 -0.378 9.0 9.0 CCND1 -0.01 0.058 -9999.0 0.0 -0.182 7.0 7.0 VAV2 -0.098 0.206 -9999.0 0.0 -0.385 71.0 71.0 RAP1/GDP -0.03 0.1 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.098 0.187 -9999.0 0.0 -0.38 67.0 67.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.049 0.118 -9999.0 0.0 -0.358 9.0 9.0 E-cadherin/beta catenin -0.089 0.145 -9999.0 0.0 -0.307 67.0 67.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.098 0.192 -9999.0 0.0 -0.388 67.0 67.0 PIK3CA 0.012 0.029 -9999.0 0.0 -0.423 1.0 1.0 Rac1/GTP -0.071 0.1 -9999.0 0.0 -0.345 10.0 10.0 E-cadherin/beta catenin/alpha catenin -0.062 0.122 -9999.0 0.0 -0.238 67.0 67.0 ITGAE 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.108 0.201 -9999.0 0.0 -0.412 67.0 67.0