Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.037 0.184 -9999.0 0.0 -0.548 20.0 20.0 IHH -0.003 0.056 -9999.0 0.0 -0.283 4.0 4.0 SHH Np/Cholesterol/GAS1 0.007 0.044 -9999.0 0.0 -0.22 8.0 8.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.007 0.044 0.219 8.0 -9999.0 0.0 8.0 SMO/beta Arrestin2 -0.03 0.143 -9999.0 0.0 -0.458 12.0 12.0 SMO -0.038 0.149 -9999.0 0.0 -0.471 13.0 13.0 AKT1 -0.002 0.076 -9999.0 0.0 -0.261 1.0 1.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.014 0.093 -9999.0 0.0 -0.309 19.0 19.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.038 0.147 -9999.0 0.0 -0.464 13.0 13.0 STIL -0.007 0.099 -9999.0 0.0 -0.359 9.0 9.0 DHH N/PTCH2 -0.021 0.093 -9999.0 0.0 -0.21 40.0 40.0 DHH N/PTCH1 -0.03 0.133 -9999.0 0.0 -0.345 21.0 21.0 PIK3CA 0.012 0.029 -9999.0 0.0 -0.423 1.0 1.0 DHH -0.031 0.111 -9999.0 0.0 -0.293 32.0 32.0 PTHLH -0.052 0.242 -9999.0 0.0 -0.818 17.0 17.0 determination of left/right symmetry -0.038 0.147 -9999.0 0.0 -0.464 13.0 13.0 PIK3R1 0.012 0.029 -9999.0 0.0 -0.423 1.0 1.0 skeletal system development -0.051 0.239 -9999.0 0.0 -0.808 17.0 17.0 IHH N/Hhip -0.004 0.061 -9999.0 0.0 -0.211 14.0 14.0 DHH N/Hhip -0.025 0.088 -9999.0 0.0 -0.196 43.0 43.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.038 0.147 -9999.0 0.0 -0.464 13.0 13.0 pancreas development -0.008 0.065 -9999.0 0.0 -0.256 14.0 14.0 HHAT 0.004 0.065 -9999.0 0.0 -0.423 5.0 5.0 PI3K 0.017 0.029 -9999.0 0.0 -0.292 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.008 0.05 -9999.0 0.0 -0.423 3.0 3.0 somite specification -0.038 0.147 -9999.0 0.0 -0.464 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.011 0.103 -9999.0 0.0 -0.291 19.0 19.0 SHH Np/Cholesterol/PTCH2 0.002 0.051 -9999.0 0.0 -0.176 16.0 16.0 SHH Np/Cholesterol/Megalin -0.092 0.106 -9999.0 0.0 -0.171 128.0 128.0 SHH 0.002 0.046 -9999.0 0.0 -0.298 5.0 5.0 catabolic process -0.016 0.125 -9999.0 0.0 -0.376 18.0 18.0 SMO/Vitamin D3 -0.022 0.121 -9999.0 0.0 -0.403 13.0 13.0 SHH Np/Cholesterol/Hhip -0.001 0.049 -9999.0 0.0 -0.154 18.0 18.0 LRP2 -0.184 0.18 -9999.0 0.0 -0.328 128.0 128.0 receptor-mediated endocytosis -0.086 0.146 -9999.0 0.0 -0.393 26.0 26.0 SHH Np/Cholesterol/BOC -0.004 0.059 -9999.0 0.0 -0.165 24.0 24.0 SHH Np/Cholesterol/CDO 0.005 0.053 -9999.0 0.0 -0.244 9.0 9.0 mesenchymal cell differentiation 0.001 0.049 0.153 18.0 -9999.0 0.0 18.0 mol:Vitamin D3 -0.009 0.105 -9999.0 0.0 -0.292 19.0 19.0 IHH N/PTCH2 -0.0 0.069 -9999.0 0.0 -0.269 11.0 11.0 CDON 0.004 0.065 -9999.0 0.0 -0.423 5.0 5.0 IHH N/PTCH1 -0.014 0.127 -9999.0 0.0 -0.378 18.0 18.0 Megalin/LRPAP1 -0.118 0.127 -9999.0 0.0 -0.292 55.0 55.0 PTCH2 -0.003 0.074 -9999.0 0.0 -0.317 11.0 11.0 SHH Np/Cholesterol 0.004 0.035 -9999.0 0.0 -0.225 5.0 5.0 PTCH1 -0.016 0.126 -9999.0 0.0 -0.378 18.0 18.0 HHIP -0.008 0.065 -9999.0 0.0 -0.256 14.0 14.0