Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.046 0.102 -9999.0 0.0 -0.199 67.0 67.0 epithelial cell differentiation -0.046 0.102 -9999.0 0.0 -0.194 67.0 67.0 CYFIP2 -0.012 0.099 -9999.0 0.0 -0.387 14.0 14.0 ENAH -0.016 0.078 -9999.0 0.0 -0.273 2.0 2.0 EGFR -0.02 0.101 -9999.0 0.0 -0.307 23.0 23.0 EPHA2 0.001 0.068 -9999.0 0.0 -0.34 8.0 8.0 MYO6 -0.048 0.101 -9999.0 0.0 -0.338 2.0 2.0 CTNNB1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.012 0.06 -9999.0 0.0 -0.238 11.0 11.0 AQP5 -0.048 0.106 -9999.0 0.0 -0.501 4.0 4.0 CTNND1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.041 0.095 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.053 0.106 -9999.0 0.0 -0.195 71.0 71.0 EGF -0.089 0.174 -9999.0 0.0 -0.369 59.0 59.0 NCKAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.058 0.142 -9999.0 0.0 -0.477 15.0 15.0 cortical microtubule organization -0.046 0.102 -9999.0 0.0 -0.194 67.0 67.0 GO:0000145 -0.04 0.089 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.044 0.104 -9999.0 0.0 -0.196 67.0 67.0 MLLT4 0.01 0.041 -9999.0 0.0 -0.423 2.0 2.0 ARF6/GDP -0.051 0.068 -9999.0 0.0 -0.242 3.0 3.0 ARF6 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.037 -9999.0 0.0 -0.209 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.034 0.091 -9999.0 0.0 -0.212 2.0 2.0 PVRL2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.042 0.098 -9999.0 0.0 -0.293 2.0 2.0 ARF6/GTP 0.032 0.035 -9999.0 0.0 -0.189 4.0 4.0 CDH1 -0.134 0.2 -9999.0 0.0 -0.396 80.0 80.0 EGFR/EGFR/EGF/EGF -0.11 0.125 -9999.0 0.0 -0.351 33.0 33.0 RhoA/GDP -0.04 0.095 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.043 0.098 -9999.0 0.0 -0.313 2.0 2.0 IGF-1R heterotetramer 0.012 0.029 -9999.0 0.0 -0.423 1.0 1.0 GIT1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.029 -9999.0 0.0 -0.423 1.0 1.0 IGF1 -0.025 0.12 -9999.0 0.0 -0.391 21.0 21.0 DIAPH1 -0.023 0.129 -9999.0 0.0 -0.587 11.0 11.0 Wnt receptor signaling pathway 0.046 0.102 0.194 67.0 -9999.0 0.0 67.0 RHOA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.069 -9999.0 0.0 -0.242 3.0 3.0 CTNNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.044 0.1 -9999.0 0.0 -0.321 2.0 2.0 EFNA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.039 0.092 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.061 0.081 -9999.0 0.0 -0.279 3.0 3.0 SEC6/SEC8 -0.052 0.07 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.054 0.107 -9999.0 0.0 -0.198 71.0 71.0 HGF/MET -0.093 0.112 -9999.0 0.0 -0.316 28.0 28.0 HGF -0.026 0.113 -9999.0 0.0 -0.327 26.0 26.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.046 0.103 -9999.0 0.0 -0.2 67.0 67.0 actin cable formation -0.005 0.079 -9999.0 0.0 -0.27 2.0 2.0 KIAA1543 -0.076 0.119 -9999.0 0.0 -0.327 20.0 20.0 KIFC3 -0.042 0.096 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.018 -9999.0 0.0 -0.256 1.0 1.0 ACTN1 -0.045 0.097 -9999.0 0.0 -0.181 71.0 71.0 NCK1/GIT1 0.02 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.046 0.102 -9999.0 0.0 -0.194 67.0 67.0 EXOC4 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.041 0.096 -9999.0 0.0 -0.181 67.0 67.0 PIP5K1C -0.041 0.096 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.02 0.082 -9999.0 0.0 -0.214 3.0 3.0 adherens junction assembly -0.06 0.117 -9999.0 0.0 -0.361 11.0 11.0 IGF-1R heterotetramer/IGF1 -0.073 0.096 -9999.0 0.0 -0.347 9.0 9.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.017 0.029 -9999.0 0.0 -0.292 2.0 2.0 MET -0.038 0.133 -9999.0 0.0 -0.368 30.0 30.0 PLEKHA7 -0.054 0.109 -9999.0 0.0 -0.313 9.0 9.0 mol:GTP 0.027 0.037 -9999.0 0.0 -0.208 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.02 0.087 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.046 0.102 -9999.0 0.0 -0.199 67.0 67.0 regulation of cell-cell adhesion -0.043 0.098 -9999.0 0.0 -0.313 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.046 0.103 -9999.0 0.0 -0.2 67.0 67.0