E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.104 0.189 0.226 1.0 -0.366 74.0 75.0 KLHL20 -0.033 0.094 0.19 4.0 -0.221 18.0 22.0 CYFIP2 0.014 0.071 -9999.0 0.0 -0.326 9.0 9.0 Rac1/GDP -0.05 0.118 -9999.0 0.0 -0.229 52.0 52.0 ENAH -0.099 0.185 0.221 1.0 -0.366 69.0 70.0 AP1M1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.02 0.084 -9999.0 0.0 -0.157 48.0 48.0 ABI1/Sra1/Nap1 -0.042 0.055 -9999.0 0.0 -0.147 25.0 25.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.011 0.119 -9999.0 0.0 -0.182 70.0 70.0 RAPGEF1 -0.086 0.169 0.215 2.0 -0.331 66.0 68.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.102 0.197 -9999.0 0.0 -0.377 74.0 74.0 CRK -0.091 0.179 0.213 1.0 -0.351 67.0 68.0 E-cadherin/gamma catenin/alpha catenin -0.015 0.117 -9999.0 0.0 -0.198 62.0 62.0 alphaE/beta7 Integrin 0.026 0.061 -9999.0 0.0 -0.223 12.0 12.0 IQGAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.044 0.03 -9999.0 0.0 -0.162 2.0 2.0 DLG1 -0.104 0.188 -9999.0 0.0 -0.369 73.0 73.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.041 0.047 -9999.0 0.0 -0.122 48.0 48.0 MLLT4 0.022 0.035 -9999.0 0.0 -0.326 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.041 0.053 -9999.0 0.0 -0.171 12.0 12.0 PI3K -0.051 0.06 -9999.0 0.0 -0.153 48.0 48.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.033 0.127 -9999.0 0.0 -0.234 62.0 62.0 TIAM1 0.009 0.081 -9999.0 0.0 -0.326 12.0 12.0 E-cadherin(dimer)/Ca2+ -0.0 0.105 -9999.0 0.0 -0.165 62.0 62.0 AKT1 -0.025 0.049 0.139 1.0 -9999.0 0.0 1.0 PIK3R1 0.026 0.025 -9999.0 0.0 -0.326 1.0 1.0 CDH1 -0.067 0.163 -9999.0 0.0 -0.326 62.0 62.0 RhoA/GDP -0.048 0.129 0.29 2.0 -0.229 57.0 59.0 actin cytoskeleton organization -0.023 0.073 0.163 5.0 -0.161 18.0 23.0 CDC42/GDP -0.049 0.128 0.29 2.0 -0.229 57.0 59.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.041 0.098 -9999.0 0.0 -0.191 64.0 64.0 ITGB7 0.01 0.081 -9999.0 0.0 -0.326 12.0 12.0 RAC1 0.026 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.0 0.113 -9999.0 0.0 -0.177 62.0 62.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.01 0.096 -9999.0 0.0 -0.161 62.0 62.0 mol:GDP -0.066 0.136 0.297 2.0 -0.259 57.0 59.0 CDC42/GTP/IQGAP1 0.037 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.027 0.036 -9999.0 0.0 -0.326 2.0 2.0 p120 catenin/RhoA/GDP -0.043 0.132 0.267 1.0 -0.234 55.0 56.0 RAC1/GTP/IQGAP1 0.033 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.012 0.056 0.136 6.0 -0.112 16.0 22.0 NME1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.108 0.19 -9999.0 0.0 -0.371 74.0 74.0 regulation of cell-cell adhesion -0.027 0.067 -9999.0 0.0 -0.14 48.0 48.0 WASF2 -0.015 0.041 0.093 3.0 -0.085 18.0 21.0 Rap1/GTP -0.022 0.096 0.259 2.0 -0.17 49.0 51.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.004 0.123 -9999.0 0.0 -0.178 69.0 69.0 CCND1 -0.016 0.066 0.155 6.0 -0.135 17.0 23.0 VAV2 -0.129 0.251 0.357 1.0 -0.65 22.0 23.0 RAP1/GDP -0.028 0.108 0.342 1.0 -0.186 51.0 52.0 adherens junction assembly -0.104 0.185 -9999.0 0.0 -0.361 74.0 74.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.015 0.113 0.216 2.0 -0.173 69.0 71.0 E-cadherin/beta catenin -0.068 0.131 -9999.0 0.0 -0.28 61.0 61.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.101 0.184 0.221 1.0 -0.359 73.0 74.0 PIK3CA 0.027 0.024 -9999.0 0.0 -0.326 1.0 1.0 Rac1/GTP -0.08 0.126 -9999.0 0.0 -0.35 21.0 21.0 E-cadherin/beta catenin/alpha catenin -0.014 0.113 -9999.0 0.0 -0.192 62.0 62.0 ITGAE 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.104 0.201 -9999.0 0.0 -0.385 74.0 74.0