Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.015 0.122 -9999.0 0.0 -0.476 11.0 11.0 IHH 0.032 0.053 0.152 2.0 -0.138 16.0 18.0 SHH Np/Cholesterol/GAS1 0.014 0.034 -9999.0 0.0 -0.169 7.0 7.0 LRPAP1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.014 0.034 0.168 7.0 -9999.0 0.0 7.0 SMO/beta Arrestin2 0.009 0.13 -9999.0 0.0 -0.411 8.0 8.0 SMO -0.012 0.122 -9999.0 0.0 -0.425 9.0 9.0 AKT1 0.001 0.103 -9999.0 0.0 -0.396 7.0 7.0 ARRB2 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.062 -9999.0 0.0 -0.326 6.0 6.0 ADRBK1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.011 0.12 -9999.0 0.0 -0.419 9.0 9.0 STIL 0.012 0.084 0.191 15.0 -0.257 10.0 25.0 DHH N/PTCH2 0.037 0.066 0.168 3.0 -0.228 11.0 14.0 DHH N/PTCH1 0.024 0.111 -9999.0 0.0 -0.343 15.0 15.0 PIK3CA 0.027 0.024 -9999.0 0.0 -0.326 1.0 1.0 DHH 0.027 0.069 -9999.0 0.0 -0.326 7.0 7.0 PTHLH -0.003 0.181 -9999.0 0.0 -0.653 14.0 14.0 determination of left/right symmetry -0.011 0.12 -9999.0 0.0 -0.419 9.0 9.0 PIK3R1 0.026 0.025 -9999.0 0.0 -0.326 1.0 1.0 skeletal system development -0.003 0.179 -9999.0 0.0 -0.646 14.0 14.0 IHH N/Hhip 0.044 0.042 0.18 2.0 -9999.0 0.0 2.0 DHH N/Hhip 0.042 0.056 0.168 3.0 -0.228 7.0 10.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.011 0.12 -9999.0 0.0 -0.419 9.0 9.0 pancreas development 0.031 0.023 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.018 0.053 -9999.0 0.0 -0.326 5.0 5.0 PI3K 0.038 0.028 -9999.0 0.0 -0.228 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.024 0.034 -9999.0 0.0 -0.326 2.0 2.0 somite specification -0.011 0.12 -9999.0 0.0 -0.419 9.0 9.0 SHH Np/Cholesterol/PTCH1 0.008 0.074 -9999.0 0.0 -0.258 11.0 11.0 SHH Np/Cholesterol/PTCH2 0.016 0.038 -9999.0 0.0 -0.169 8.0 8.0 SHH Np/Cholesterol/Megalin -0.007 0.098 -9999.0 0.0 -0.181 49.0 49.0 SHH 0.001 0.034 -9999.0 0.0 -0.223 5.0 5.0 catabolic process 0.009 0.107 -9999.0 0.0 -0.361 16.0 16.0 SMO/Vitamin D3 0.009 0.101 0.243 5.0 -0.292 12.0 17.0 SHH Np/Cholesterol/Hhip 0.018 0.032 -9999.0 0.0 -0.167 5.0 5.0 LRP2 -0.031 0.173 -9999.0 0.0 -0.326 55.0 55.0 receptor-mediated endocytosis -0.029 0.123 -9999.0 0.0 -0.342 16.0 16.0 SHH Np/Cholesterol/BOC 0.016 0.043 -9999.0 0.0 -0.169 10.0 10.0 SHH Np/Cholesterol/CDO 0.011 0.043 -9999.0 0.0 -0.186 9.0 9.0 mesenchymal cell differentiation -0.018 0.032 0.167 5.0 -9999.0 0.0 5.0 mol:Vitamin D3 0.025 0.091 0.218 15.0 -0.259 11.0 26.0 IHH N/PTCH2 0.038 0.055 0.189 1.0 -0.245 4.0 5.0 CDON 0.018 0.053 -9999.0 0.0 -0.326 5.0 5.0 IHH N/PTCH1 0.02 0.112 -9999.0 0.0 -0.363 16.0 16.0 Megalin/LRPAP1 -0.006 0.13 -9999.0 0.0 -0.227 55.0 55.0 PTCH2 0.025 0.05 -9999.0 0.0 -0.326 4.0 4.0 SHH Np/Cholesterol 0.013 0.028 -9999.0 0.0 -0.165 5.0 5.0 PTCH1 0.009 0.107 -9999.0 0.0 -0.362 16.0 16.0 HHIP 0.031 0.023 -9999.0 0.0 -9999.0 0.0 0.0