Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.035 0.094 -9999.0 0.0 -0.182 63.0 63.0 epithelial cell differentiation -0.004 0.102 -9999.0 0.0 -0.164 62.0 62.0 CYFIP2 0.014 0.071 -9999.0 0.0 -0.326 9.0 9.0 ENAH -0.046 0.066 0.266 1.0 -0.238 2.0 3.0 EGFR 0.023 0.063 -9999.0 0.0 -0.326 6.0 6.0 EPHA2 0.024 0.049 -9999.0 0.0 -0.326 4.0 4.0 MYO6 -0.049 0.08 0.21 5.0 -0.162 62.0 67.0 CTNNB1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.043 0.052 -9999.0 0.0 -0.187 9.0 9.0 AQP5 -0.028 0.094 0.424 1.0 -0.438 4.0 5.0 CTNND1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.047 0.077 0.208 5.0 -0.158 60.0 65.0 regulation of calcium-dependent cell-cell adhesion -0.046 0.083 0.22 5.0 -0.163 55.0 60.0 EGF -0.025 0.139 -9999.0 0.0 -0.326 38.0 38.0 NCKAP1 0.029 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.053 0.119 0.384 1.0 -0.339 21.0 22.0 cortical microtubule organization -0.004 0.102 -9999.0 0.0 -0.164 62.0 62.0 GO:0000145 -0.047 0.072 0.196 5.0 -0.151 60.0 65.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.0 0.105 -9999.0 0.0 -0.165 62.0 62.0 MLLT4 0.022 0.035 -9999.0 0.0 -0.326 2.0 2.0 ARF6/GDP -0.056 0.06 -9999.0 0.0 -0.156 2.0 2.0 ARF6 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.043 -9999.0 0.0 -0.171 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.036 0.071 0.21 4.0 -9999.0 0.0 4.0 PVRL2 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.044 0.075 0.216 4.0 -0.16 55.0 59.0 ARF6/GTP 0.064 0.046 -9999.0 0.0 -0.162 4.0 4.0 CDH1 -0.067 0.163 -9999.0 0.0 -0.326 62.0 62.0 EGFR/EGFR/EGF/EGF -0.039 0.117 -9999.0 0.0 -0.178 85.0 85.0 RhoA/GDP -0.002 0.1 -9999.0 0.0 -0.159 62.0 62.0 actin cytoskeleton organization -0.054 0.079 0.194 5.0 -0.166 54.0 59.0 IGF-1R heterotetramer 0.027 0.024 -9999.0 0.0 -0.326 1.0 1.0 GIT1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.024 -9999.0 0.0 -0.326 1.0 1.0 IGF1 0.007 0.09 -9999.0 0.0 -0.326 15.0 15.0 DIAPH1 -0.033 0.217 -9999.0 0.0 -0.563 23.0 23.0 Wnt receptor signaling pathway 0.004 0.102 0.164 62.0 -9999.0 0.0 62.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.06 -9999.0 0.0 -0.155 56.0 56.0 CTNNA1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.055 0.08 0.195 5.0 -0.169 54.0 59.0 EFNA1 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.052 0.076 0.202 5.0 -0.157 64.0 69.0 Ephrin A1/EPHA2 -0.01 0.092 -9999.0 0.0 -0.157 59.0 59.0 SEC6/SEC8 -0.05 0.062 -9999.0 0.0 -0.155 55.0 55.0 MGAT3 -0.046 0.084 0.221 5.0 -0.165 55.0 60.0 HGF/MET -0.024 0.11 -9999.0 0.0 -0.175 70.0 70.0 HGF 0.015 0.078 0.115 13.0 -0.326 10.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.035 0.094 -9999.0 0.0 -0.183 63.0 63.0 actin cable formation -0.018 0.102 0.263 10.0 -0.255 4.0 14.0 KIAA1543 -0.05 0.077 0.198 5.0 -0.157 64.0 69.0 KIFC3 -0.05 0.075 0.235 3.0 -0.16 61.0 64.0 NCK1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.05 0.079 0.21 5.0 -0.16 64.0 69.0 NCK1/GIT1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.004 0.102 -9999.0 0.0 -0.164 62.0 62.0 EXOC4 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.048 0.079 0.21 5.0 -0.16 61.0 66.0 PIP5K1C -0.047 0.078 0.21 5.0 -0.16 60.0 65.0 LIMA1 0.029 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.036 0.092 0.446 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.049 0.092 0.275 3.0 -0.289 10.0 13.0 IGF-1R heterotetramer/IGF1 -0.02 0.106 -9999.0 0.0 -0.167 71.0 71.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.03 -9999.0 0.0 -0.228 2.0 2.0 MET 0.002 0.096 -9999.0 0.0 -0.326 17.0 17.0 PLEKHA7 -0.051 0.083 0.21 5.0 -0.164 64.0 69.0 mol:GTP 0.057 0.042 -9999.0 0.0 -0.17 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.022 0.108 0.302 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization -0.035 0.094 -9999.0 0.0 -0.182 63.0 63.0 regulation of cell-cell adhesion -0.054 0.079 0.194 5.0 -0.166 54.0 59.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.035 0.094 -9999.0 0.0 -0.183 63.0 63.0