Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	42.0	294.0	7.0	-0.045	0.004	1000.0	-1000.0	0.0	-1000.0
E-cadherin signaling events	37.0	188.0	5.0	-0.067	0.029	1000.0	-1000.0	0.02	-1000.0
IL4-mediated signaling events	34.0	3166.0	91.0	-0.53	0.395	1000.0	-1000.0	-0.07	-1000.0
TCR signaling in naïve CD8+ T cells	31.0	2907.0	93.0	-0.205	0.122	1000.0	-1000.0	-0.036	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	31.0	2340.0	74.0	-0.067	0.064	1000.0	-1000.0	-0.041	-1000.0
E-cadherin signaling in the nascent adherens junction	30.0	2319.0	76.0	-0.129	0.044	1000.0	-1000.0	-0.037	-1000.0
IL23-mediated signaling events	29.0	1747.0	60.0	-0.278	0.029	1000.0	-1000.0	-0.086	-1000.0
Angiopoietin receptor Tie2-mediated signaling	29.0	2579.0	88.0	-0.215	0.039	1000.0	-1000.0	-0.049	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	29.0	2297.0	78.0	-0.181	0.057	1000.0	-1000.0	-0.043	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	27.0	1862.0	68.0	-0.303	0.084	1000.0	-1000.0	-0.047	-1000.0
Signaling events regulated by Ret tyrosine kinase	25.0	2091.0	82.0	-0.054	0.033	1000.0	-1000.0	-0.034	-1000.0
IL12-mediated signaling events	24.0	2162.0	87.0	-0.278	0.061	1000.0	-1000.0	-0.042	-1000.0
Endothelins	24.0	2354.0	96.0	-0.116	0.05	1000.0	-1000.0	-0.032	-1000.0
E-cadherin signaling in keratinocytes	24.0	1054.0	43.0	-0.07	0.032	1000.0	-1000.0	-0.012	-1000.0
BCR signaling pathway	23.0	2319.0	99.0	-0.142	0.036	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	20.0	771.0	38.0	-0.048	0.032	1000.0	-1000.0	-0.013	-1000.0
Nectin adhesion pathway	20.0	1308.0	63.0	-0.099	0.044	1000.0	-1000.0	-0.031	-1000.0
Calcium signaling in the CD4+ TCR pathway	20.0	627.0	31.0	-0.085	0.03	1000.0	-1000.0	-0.022	-1000.0
Glucocorticoid receptor regulatory network	19.0	2273.0	114.0	-0.232	0.123	1000.0	-1000.0	-0.037	-1000.0
IL27-mediated signaling events	19.0	989.0	51.0	-0.176	0.104	1000.0	-1000.0	-0.064	-1000.0
LPA receptor mediated events	19.0	2033.0	102.0	-0.077	0.033	1000.0	-1000.0	-0.065	-1000.0
Syndecan-1-mediated signaling events	18.0	625.0	34.0	-0.053	0.03	1000.0	-1000.0	-0.015	-1000.0
Glypican 1 network	18.0	883.0	48.0	-0.038	0.042	1000.0	-1000.0	-0.02	-1000.0
EGFR-dependent Endothelin signaling events	18.0	379.0	21.0	-0.036	0.042	1000.0	-1000.0	-0.028	-1000.0
Thromboxane A2 receptor signaling	17.0	1855.0	105.0	-0.09	0.035	1000.0	-1000.0	-0.036	-1000.0
p75(NTR)-mediated signaling	17.0	2182.0	125.0	-0.051	0.073	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	17.0	843.0	47.0	-0.022	0.037	1000.0	-1000.0	-0.035	-1000.0
Signaling mediated by p38-alpha and p38-beta	17.0	787.0	44.0	-0.068	0.029	1000.0	-1000.0	-0.013	-1000.0
Integrins in angiogenesis	17.0	1499.0	84.0	-0.1	0.055	1000.0	-1000.0	-0.018	-1000.0
Glypican 2 network	17.0	68.0	4.0	0.01	0.013	1000.0	-1000.0	0.018	-1000.0
TCGA08_retinoblastoma	17.0	139.0	8.0	-0.007	0.05	1000.0	-1000.0	-0.006	-1000.0
Caspase cascade in apoptosis	16.0	1200.0	74.0	-0.061	0.041	1000.0	-1000.0	-0.025	-1000.0
a4b1 and a4b7 Integrin signaling	16.0	83.0	5.0	0.003	0.021	1000.0	-1000.0	0.019	-1000.0
EPHB forward signaling	16.0	1403.0	85.0	-0.056	0.055	1000.0	-1000.0	-0.041	-1000.0
Wnt signaling	16.0	114.0	7.0	-0.026	0.024	1000.0	-1000.0	-0.001	-1000.0
JNK signaling in the CD4+ TCR pathway	15.0	262.0	17.0	-0.089	0.039	1000.0	-1000.0	-0.021	-1000.0
Noncanonical Wnt signaling pathway	15.0	407.0	26.0	-0.036	0.028	1000.0	-1000.0	-0.02	-1000.0
Syndecan-4-mediated signaling events	15.0	1035.0	67.0	-0.038	0.038	1000.0	-1000.0	-0.022	-1000.0
HIF-1-alpha transcription factor network	14.0	1131.0	76.0	-0.023	0.067	1000.0	-1000.0	-0.02	-1000.0
Arf6 signaling events	14.0	879.0	62.0	-0.025	0.059	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PTP1B	14.0	1098.0	76.0	-0.06	0.036	1000.0	-1000.0	-0.02	-1000.0
BMP receptor signaling	14.0	1152.0	81.0	-0.053	0.051	1000.0	-1000.0	-0.015	-1000.0
Ceramide signaling pathway	14.0	1083.0	76.0	-0.04	0.047	1000.0	-1000.0	-0.018	-1000.0
Class IB PI3K non-lipid kinase events	14.0	42.0	3.0	-0.007	0.007	1000.0	-1000.0	-0.02	-1000.0
Reelin signaling pathway	13.0	768.0	56.0	-0.028	0.057	1000.0	-1000.0	-0.014	-1000.0
TRAIL signaling pathway	13.0	649.0	48.0	-0.025	0.042	1000.0	-1000.0	-0.026	-1000.0
Ephrin B reverse signaling	13.0	658.0	48.0	-0.045	0.038	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	13.0	602.0	45.0	-0.046	0.058	1000.0	-1000.0	-0.028	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1126.0	86.0	-0.115	0.084	1000.0	-1000.0	-0.034	-1000.0
S1P4 pathway	13.0	342.0	25.0	-0.031	0.037	1000.0	-1000.0	-0.011	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1243.0	97.0	-0.044	0.051	1000.0	-1000.0	-0.051	-1000.0
IFN-gamma pathway	12.0	871.0	68.0	-0.034	0.038	1000.0	-1000.0	-0.029	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	12.0	637.0	52.0	-0.052	0.06	1000.0	-1000.0	-0.02	-1000.0
IL2 signaling events mediated by PI3K	12.0	739.0	58.0	-0.094	0.044	1000.0	-1000.0	-0.028	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	205.0	17.0	-0.018	0.052	1000.0	-1000.0	-0.008	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	11.0	1016.0	85.0	-0.023	0.046	1000.0	-1000.0	-0.036	-1000.0
amb2 Integrin signaling	11.0	932.0	82.0	-0.027	0.048	1000.0	-1000.0	-0.012	-1000.0
Effects of Botulinum toxin	11.0	289.0	26.0	-0.018	0.043	1000.0	-1000.0	-0.001	-1000.0
Class I PI3K signaling events	11.0	851.0	73.0	-0.098	0.052	1000.0	-1000.0	-0.023	-1000.0
LPA4-mediated signaling events	10.0	120.0	12.0	-0.039	0.006	1000.0	-1000.0	-0.017	-1000.0
ErbB2/ErbB3 signaling events	10.0	670.0	65.0	-0.034	0.042	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by the Hedgehog family	10.0	559.0	52.0	-0.031	0.044	1000.0	-1000.0	-0.024	-1000.0
Syndecan-2-mediated signaling events	10.0	705.0	69.0	-0.015	0.043	1000.0	-1000.0	-0.033	-1000.0
ceramide signaling pathway	10.0	518.0	49.0	-0.022	0.042	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-gamma and p38-delta	10.0	155.0	15.0	-0.018	0.028	1000.0	-1000.0	-0.022	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	10.0	1231.0	120.0	-0.07	0.071	1000.0	-1000.0	-0.039	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	489.0	54.0	-0.023	0.041	1000.0	-1000.0	-0.018	-1000.0
Cellular roles of Anthrax toxin	9.0	370.0	39.0	-0.03	0.029	1000.0	-1000.0	-0.017	-1000.0
FOXA2 and FOXA3 transcription factor networks	9.0	453.0	46.0	-0.156	0.034	1000.0	-1000.0	-0.062	-1000.0
PDGFR-alpha signaling pathway	9.0	396.0	44.0	-0.02	0.056	1000.0	-1000.0	-0.031	-1000.0
S1P1 pathway	9.0	342.0	36.0	-0.059	0.029	1000.0	-1000.0	-0.017	-1000.0
TCGA08_p53	9.0	65.0	7.0	-0.012	0.026	1000.0	-1000.0	-0.002	-1000.0
PDGFR-beta signaling pathway	9.0	929.0	97.0	-0.057	0.064	1000.0	-1000.0	-0.033	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	8.0	323.0	37.0	-0.032	0.05	1000.0	-1000.0	-0.019	-1000.0
IL1-mediated signaling events	8.0	527.0	62.0	-0.026	0.077	1000.0	-1000.0	-0.022	-1000.0
S1P5 pathway	8.0	144.0	17.0	-0.027	0.034	1000.0	-1000.0	-0.004	-1000.0
Paxillin-dependent events mediated by a4b1	8.0	300.0	36.0	-0.039	0.048	1000.0	-1000.0	-0.031	-1000.0
IL2 signaling events mediated by STAT5	8.0	193.0	22.0	-0.037	0.03	1000.0	-1000.0	-0.022	-1000.0
Presenilin action in Notch and Wnt signaling	7.0	436.0	61.0	-0.013	0.073	1000.0	-1000.0	-0.029	-1000.0
EPO signaling pathway	7.0	401.0	55.0	-0.001	0.05	1000.0	-1000.0	-0.018	-1000.0
Canonical Wnt signaling pathway	7.0	382.0	51.0	-0.047	0.063	1000.0	-1000.0	-0.026	-1000.0
Regulation of p38-alpha and p38-beta	7.0	415.0	54.0	-0.058	0.059	1000.0	-1000.0	-0.039	-1000.0
IGF1 pathway	7.0	430.0	57.0	-0.027	0.062	1000.0	-1000.0	-0.025	-1000.0
Insulin Pathway	7.0	546.0	74.0	-0.088	0.065	1000.0	-1000.0	-0.036	-1000.0
Rapid glucocorticoid signaling	7.0	140.0	20.0	-0.0	0.029	1000.0	-1000.0	-0.0	-1000.0
Visual signal transduction: Rods	7.0	406.0	52.0	-0.0	0.047	1000.0	-1000.0	-0.008	-1000.0
Regulation of Androgen receptor activity	7.0	520.0	70.0	-0.105	0.037	1000.0	-1000.0	-0.045	-1000.0
Regulation of nuclear SMAD2/3 signaling	6.0	896.0	136.0	-0.29	0.07	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	6.0	186.0	28.0	-0.027	0.044	1000.0	-1000.0	-0.018	-1000.0
mTOR signaling pathway	6.0	322.0	53.0	-0.041	0.034	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class III	6.0	240.0	40.0	-0.061	0.048	1000.0	-1000.0	-0.039	-1000.0
Atypical NF-kappaB pathway	6.0	188.0	31.0	-0.017	0.038	1000.0	-1000.0	-0.019	-1000.0
Nongenotropic Androgen signaling	6.0	363.0	52.0	-0.052	0.044	1000.0	-1000.0	-0.018	-1000.0
S1P3 pathway	6.0	289.0	42.0	-0.027	0.045	1000.0	-1000.0	-0.022	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	6.0	208.0	33.0	-0.003	0.062	1000.0	-1000.0	-0.028	-1000.0
Aurora B signaling	6.0	407.0	67.0	-0.066	0.065	1000.0	-1000.0	-0.038	-1000.0
Coregulation of Androgen receptor activity	5.0	408.0	76.0	-0.072	0.05	1000.0	-1000.0	-0.018	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	385.0	65.0	-0.041	0.068	1000.0	-1000.0	-0.039	-1000.0
HIF-2-alpha transcription factor network	5.0	226.0	43.0	-0.104	0.107	1000.0	-1000.0	-0.034	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	5.0	428.0	83.0	-0.033	0.054	1000.0	-1000.0	-0.018	-1000.0
FoxO family signaling	5.0	342.0	64.0	-0.186	0.043	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	5.0	324.0	58.0	-0.037	0.056	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	5.0	153.0	26.0	-0.022	0.061	1000.0	-1000.0	-0.006	-1000.0
IL6-mediated signaling events	5.0	432.0	75.0	-0.037	0.084	1000.0	-1000.0	-0.044	-1000.0
Regulation of Telomerase	5.0	579.0	102.0	-0.086	0.058	1000.0	-1000.0	-0.03	-1000.0
FOXM1 transcription factor network	5.0	297.0	51.0	-0.016	0.084	1000.0	-1000.0	-0.072	-1000.0
ErbB4 signaling events	4.0	337.0	69.0	-0.073	0.066	1000.0	-1000.0	-0.019	-1000.0
Visual signal transduction: Cones	4.0	164.0	38.0	-0.01	0.049	1000.0	-1000.0	-0.013	-1000.0
Arf6 downstream pathway	4.0	180.0	43.0	-0.04	0.05	1000.0	-1000.0	-0.028	-1000.0
Class I PI3K signaling events mediated by Akt	4.0	283.0	68.0	-0.038	0.053	1000.0	-1000.0	-0.02	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	107.0	34.0	-0.043	0.066	1000.0	-1000.0	-0.031	-1000.0
Canonical NF-kappaB pathway	3.0	142.0	39.0	-0.007	0.06	1000.0	-1000.0	-0.015	-1000.0
BARD1 signaling events	3.0	207.0	57.0	-0.056	0.062	1000.0	-1000.0	-0.043	-1000.0
PLK2 and PLK4 events	3.0	11.0	3.0	-0.017	-1000.0	1000.0	-1000.0	-0.018	-1000.0
PLK1 signaling events	3.0	338.0	85.0	-0.007	0.052	1000.0	-1000.0	-0.02	-1000.0
Syndecan-3-mediated signaling events	3.0	110.0	35.0	0.0	0.073	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	460.0	125.0	-0.014	0.068	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by PRL	3.0	125.0	34.0	-0.027	0.046	1000.0	-1000.0	-0.023	-1000.0
p38 MAPK signaling pathway	3.0	167.0	44.0	-0.041	0.047	1000.0	-1000.0	-0.017	-1000.0
Aurora A signaling	2.0	150.0	60.0	-0.028	0.061	1000.0	-1000.0	-0.017	-1000.0
Aurora C signaling	2.0	15.0	7.0	-0.0	0.047	1000.0	-1000.0	-0.006	-1000.0
Insulin-mediated glucose transport	2.0	77.0	32.0	-0.026	0.053	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class I	2.0	219.0	104.0	-0.054	0.068	1000.0	-1000.0	-0.04	-1000.0
Arf6 trafficking events	2.0	149.0	71.0	-0.041	0.053	1000.0	-1000.0	-0.033	-1000.0
VEGFR1 specific signals	2.0	131.0	56.0	-0.033	0.055	1000.0	-1000.0	-0.022	-1000.0
Signaling events mediated by HDAC Class II	1.0	127.0	75.0	-0.031	0.073	1000.0	-1000.0	-0.021	-1000.0
Circadian rhythm pathway	1.0	38.0	22.0	-0.007	0.045	1000.0	-1000.0	-0.024	-1000.0
Arf1 pathway	1.0	92.0	54.0	-0.002	0.048	1000.0	-1000.0	-0.013	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	11.0	23.0	0.004	0.058	1000.0	-1000.0	-0.01	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	5.0	27.0	-0.011	0.068	1000.0	-1000.0	-0.026	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	-0.0	0.074	1000.0	-1000.0	-0.0	-1000.0
Total	1502	90243	7203	-7.97443130903	-993.096842633	131000	-131000	-3.38185442812	-131000