Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.314 -9999.0 0.0 -0.923 4.0 4.0 IHH -0.122 0.32 -9999.0 0.0 -0.908 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.165 0.242 -9999.0 0.0 -0.555 11.0 11.0 LRPAP1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.164 0.24 0.55 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.117 0.282 -9999.0 0.0 -0.772 5.0 5.0 SMO -0.129 0.298 -9999.0 0.0 -0.822 5.0 5.0 AKT1 -0.034 0.118 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.056 0.188 -9999.0 0.0 -0.555 5.0 5.0 ADRBK1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.126 0.292 -9999.0 0.0 -0.802 5.0 5.0 STIL -0.185 0.353 -9999.0 0.0 -0.859 6.0 6.0 DHH N/PTCH2 -0.039 0.129 -9999.0 0.0 -0.662 1.0 1.0 DHH N/PTCH1 -0.125 0.242 -9999.0 0.0 -0.721 4.0 4.0 PIK3CA 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.011 0.13 -9999.0 0.0 -0.853 1.0 1.0 PTHLH -0.118 0.37 -9999.0 0.0 -1.091 4.0 4.0 determination of left/right symmetry -0.126 0.292 -9999.0 0.0 -0.802 5.0 5.0 PIK3R1 0.009 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.116 0.362 -9999.0 0.0 -1.066 4.0 4.0 IHH N/Hhip -0.241 0.336 -9999.0 0.0 -0.715 12.0 12.0 DHH N/Hhip -0.17 0.252 -9999.0 0.0 -0.662 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.126 0.292 -9999.0 0.0 -0.802 5.0 5.0 pancreas development -0.202 0.321 -9999.0 0.0 -0.639 14.0 14.0 HHAT -0.011 0.13 -9999.0 0.0 -0.853 1.0 1.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.042 0.194 -9999.0 0.0 -0.729 3.0 3.0 somite specification -0.126 0.292 -9999.0 0.0 -0.802 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.194 0.344 -9999.0 0.0 -0.855 6.0 6.0 SHH Np/Cholesterol/PTCH2 -0.152 0.222 -9999.0 0.0 -0.53 10.0 10.0 SHH Np/Cholesterol/Megalin -0.229 0.287 -9999.0 0.0 -0.633 12.0 12.0 SHH -0.158 0.279 -9999.0 0.0 -0.563 13.0 13.0 catabolic process -0.094 0.274 -9999.0 0.0 -0.66 7.0 7.0 SMO/Vitamin D3 -0.194 0.347 -9999.0 0.0 -0.936 5.0 5.0 SHH Np/Cholesterol/Hhip -0.254 0.289 -9999.0 0.0 -0.619 14.0 14.0 LRP2 -0.162 0.291 -9999.0 0.0 -0.605 12.0 12.0 receptor-mediated endocytosis -0.261 0.335 -9999.0 0.0 -0.842 8.0 8.0 SHH Np/Cholesterol/BOC -0.171 0.227 -9999.0 0.0 -0.53 11.0 11.0 SHH Np/Cholesterol/CDO -0.141 0.217 -9999.0 0.0 -0.533 9.0 9.0 mesenchymal cell differentiation 0.252 0.286 0.612 14.0 -9999.0 0.0 14.0 mol:Vitamin D3 -0.192 0.347 -9999.0 0.0 -0.86 6.0 6.0 IHH N/PTCH2 -0.102 0.233 -9999.0 0.0 -0.589 7.0 7.0 CDON -0.002 0.074 -9999.0 0.0 -0.48 1.0 1.0 IHH N/PTCH1 -0.096 0.277 -9999.0 0.0 -0.67 7.0 7.0 Megalin/LRPAP1 -0.124 0.215 -9999.0 0.0 -0.662 4.0 4.0 PTCH2 -0.025 0.125 -9999.0 0.0 -0.48 3.0 3.0 SHH Np/Cholesterol -0.137 0.22 -9999.0 0.0 -0.539 9.0 9.0 PTCH1 -0.095 0.275 -9999.0 0.0 -0.663 7.0 7.0 HHIP -0.202 0.322 -9999.0 0.0 -0.64 14.0 14.0