Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.019 0.128 -9999.0 0.0 -0.385 3.0 3.0 IHH -0.027 0.185 -9999.0 0.0 -0.467 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.02 0.104 -9999.0 0.0 -0.264 6.0 6.0 LRPAP1 0.035 0.01 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.02 0.103 0.262 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 -0.036 0.199 -9999.0 0.0 -0.497 5.0 5.0 SMO -0.054 0.196 -9999.0 0.0 -0.487 6.0 6.0 AKT1 -0.016 0.136 -9999.0 0.0 -0.611 1.0 1.0 ARRB2 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.03 0.078 -9999.0 0.0 -0.468 1.0 1.0 ADRBK1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.051 0.193 -9999.0 0.0 -0.479 6.0 6.0 STIL -0.048 0.159 -9999.0 0.0 -0.437 4.0 4.0 DHH N/PTCH2 0.048 0.061 -9999.0 0.0 -0.341 1.0 1.0 DHH N/PTCH1 -0.016 0.153 -9999.0 0.0 -0.337 7.0 7.0 PIK3CA 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.026 0.076 -9999.0 0.0 -0.468 1.0 1.0 PTHLH -0.049 0.196 -9999.0 0.0 -0.632 3.0 3.0 determination of left/right symmetry -0.051 0.193 -9999.0 0.0 -0.479 6.0 6.0 PIK3R1 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.049 0.194 -9999.0 0.0 -0.627 3.0 3.0 IHH N/Hhip -0.045 0.19 -9999.0 0.0 -0.379 10.0 10.0 DHH N/Hhip -0.008 0.149 -9999.0 0.0 -0.342 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.051 0.193 -9999.0 0.0 -0.479 6.0 6.0 pancreas development -0.029 0.178 -9999.0 0.0 -0.468 6.0 6.0 HHAT 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.047 0.021 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.015 0.107 -9999.0 0.0 -0.468 2.0 2.0 somite specification -0.051 0.193 -9999.0 0.0 -0.479 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.051 0.156 -9999.0 0.0 -0.327 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.007 0.099 -9999.0 0.0 -0.266 5.0 5.0 SHH Np/Cholesterol/Megalin -0.031 0.137 -9999.0 0.0 -0.301 8.0 8.0 SHH -0.046 0.109 -9999.0 0.0 -0.342 5.0 5.0 catabolic process -0.03 0.155 -9999.0 0.0 -0.385 6.0 6.0 SMO/Vitamin D3 -0.058 0.182 -9999.0 0.0 -0.445 6.0 6.0 SHH Np/Cholesterol/Hhip -0.042 0.144 -9999.0 0.0 -0.293 10.0 10.0 LRP2 -0.001 0.151 -9999.0 0.0 -0.468 4.0 4.0 receptor-mediated endocytosis -0.073 0.206 -9999.0 0.0 -0.547 5.0 5.0 SHH Np/Cholesterol/BOC -0.015 0.107 -9999.0 0.0 -0.266 6.0 6.0 SHH Np/Cholesterol/CDO -0.011 0.095 -9999.0 0.0 -0.262 5.0 5.0 mesenchymal cell differentiation 0.042 0.143 0.291 10.0 -9999.0 0.0 10.0 mol:Vitamin D3 -0.041 0.165 -9999.0 0.0 -0.341 8.0 8.0 IHH N/PTCH2 0.012 0.123 -9999.0 0.0 -0.314 5.0 5.0 CDON 0.034 0.015 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.018 0.158 -9999.0 0.0 -0.388 6.0 6.0 Megalin/LRPAP1 0.023 0.116 -9999.0 0.0 -0.334 4.0 4.0 PTCH2 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.02 0.09 -9999.0 0.0 -0.261 5.0 5.0 PTCH1 -0.03 0.155 -9999.0 0.0 -0.386 6.0 6.0 HHIP -0.029 0.178 -9999.0 0.0 -0.468 6.0 6.0