Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.036 0.207 -9999.0 0.0 -0.658 33.0 33.0 IHH 0.003 0.082 -9999.0 0.0 -0.251 20.0 20.0 SHH Np/Cholesterol/GAS1 -0.001 0.069 -9999.0 0.0 -0.34 6.0 6.0 LRPAP1 0.027 0.032 -9999.0 0.0 -0.577 1.0 1.0 dorsoventral neural tube patterning 0.001 0.068 0.338 6.0 -9999.0 0.0 6.0 SMO/beta Arrestin2 0.016 0.112 -9999.0 0.0 -0.46 4.0 4.0 SMO -0.002 0.109 -9999.0 0.0 -0.431 8.0 8.0 AKT1 0.028 0.076 -9999.0 0.0 -0.63 2.0 2.0 ARRB2 0.027 0.017 -9999.0 0.0 -0.259 1.0 1.0 BOC 0.007 0.109 -9999.0 0.0 -0.513 15.0 15.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.0 0.109 -9999.0 0.0 -0.425 8.0 8.0 STIL -0.006 0.104 -9999.0 0.0 -0.421 8.0 8.0 DHH N/PTCH2 0.002 0.129 -9999.0 0.0 -0.436 28.0 28.0 DHH N/PTCH1 -0.012 0.14 -9999.0 0.0 -0.373 37.0 37.0 PIK3CA 0.026 0.044 -9999.0 0.0 -0.577 2.0 2.0 DHH -0.001 0.127 -9999.0 0.0 -0.543 19.0 19.0 PTHLH -0.056 0.286 -9999.0 0.0 -0.914 34.0 34.0 determination of left/right symmetry 0.0 0.109 -9999.0 0.0 -0.425 8.0 8.0 PIK3R1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.055 0.282 -9999.0 0.0 -0.9 34.0 34.0 IHH N/Hhip 0.002 0.083 -9999.0 0.0 -0.266 7.0 7.0 DHH N/Hhip -0.001 0.113 -9999.0 0.0 -0.429 17.0 17.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.0 0.109 -9999.0 0.0 -0.425 8.0 8.0 pancreas development 0.0 0.082 -9999.0 0.0 -0.259 34.0 34.0 HHAT 0.026 0.032 -9999.0 0.0 -0.577 1.0 1.0 PI3K 0.039 0.035 -9999.0 0.0 -0.424 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.01 0.111 -9999.0 0.0 -0.306 42.0 42.0 somite specification 0.0 0.109 -9999.0 0.0 -0.425 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.008 0.099 -9999.0 0.0 -0.395 9.0 9.0 SHH Np/Cholesterol/PTCH2 0.005 0.07 -9999.0 0.0 -0.32 12.0 12.0 SHH Np/Cholesterol/Megalin -0.023 0.11 -9999.0 0.0 -0.344 31.0 31.0 SHH -0.01 0.045 -9999.0 0.0 -0.424 1.0 1.0 catabolic process -0.009 0.121 -9999.0 0.0 -0.358 34.0 34.0 SMO/Vitamin D3 0.002 0.111 -9999.0 0.0 -0.441 7.0 7.0 SHH Np/Cholesterol/Hhip 0.002 0.059 -9999.0 0.0 -0.261 6.0 6.0 LRP2 -0.05 0.191 -9999.0 0.0 -0.469 59.0 59.0 receptor-mediated endocytosis -0.025 0.133 -9999.0 0.0 -0.522 10.0 10.0 SHH Np/Cholesterol/BOC 0.008 0.066 -9999.0 0.0 -0.327 9.0 9.0 SHH Np/Cholesterol/CDO -0.001 0.064 -9999.0 0.0 -0.296 4.0 4.0 mesenchymal cell differentiation -0.002 0.059 0.26 6.0 -9999.0 0.0 6.0 mol:Vitamin D3 0.004 0.109 0.288 1.0 -0.396 9.0 10.0 IHH N/PTCH2 0.007 0.106 -9999.0 0.0 -0.391 19.0 19.0 CDON -0.009 0.1 -9999.0 0.0 -0.27 47.0 47.0 IHH N/PTCH1 0.0 0.127 -9999.0 0.0 -0.361 34.0 34.0 Megalin/LRPAP1 -0.021 0.148 -9999.0 0.0 -0.343 59.0 59.0 PTCH2 0.005 0.111 -9999.0 0.0 -0.483 17.0 17.0 SHH Np/Cholesterol 0.006 0.035 -9999.0 0.0 -0.331 1.0 1.0 PTCH1 -0.009 0.121 -9999.0 0.0 -0.36 34.0 34.0 HHIP 0.0 0.082 -9999.0 0.0 -0.259 34.0 34.0