Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.029 -9999.0 0.0 -0.274 3.0 3.0 epithelial cell differentiation 0.058 0.019 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.032 -9999.0 0.0 -0.577 1.0 1.0 ENAH 0.025 0.085 0.506 8.0 -9999.0 0.0 8.0 EGFR 0.002 0.12 -9999.0 0.0 -0.539 17.0 17.0 EPHA2 0.025 0.044 -9999.0 0.0 -0.577 2.0 2.0 MYO6 0.036 0.074 0.447 10.0 -9999.0 0.0 10.0 CTNNB1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.055 0.026 -9999.0 0.0 -0.363 1.0 1.0 AQP5 -0.046 0.175 -9999.0 0.0 -0.505 46.0 46.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.054 0.41 6.0 -9999.0 0.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.119 0.415 3.0 -0.295 54.0 57.0 EGF -0.033 0.148 -9999.0 0.0 -0.335 64.0 64.0 NCKAP1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.043 0.168 -9999.0 0.0 -0.481 45.0 45.0 cortical microtubule organization 0.058 0.019 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.015 0.054 0.4 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.064 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.064 0.035 -9999.0 0.0 -0.331 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.017 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.022 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.071 0.035 -9999.0 0.0 -0.308 1.0 1.0 CDH1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF 0.01 0.104 -9999.0 0.0 -0.304 29.0 29.0 RhoA/GDP 0.06 0.019 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.024 0.059 0.416 7.0 -9999.0 0.0 7.0 IGF-1R heterotetramer 0.027 0.031 -9999.0 0.0 -0.576 1.0 1.0 GIT1 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.031 -9999.0 0.0 -0.577 1.0 1.0 IGF1 -0.057 0.173 -9999.0 0.0 -0.355 83.0 83.0 DIAPH1 0.052 0.062 -9999.0 0.0 -0.624 1.0 1.0 Wnt receptor signaling pathway -0.058 0.019 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.025 0.059 0.418 7.0 -9999.0 0.0 7.0 EFNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.016 0.041 0.358 2.0 -0.291 1.0 3.0 Ephrin A1/EPHA2 0.049 0.028 -9999.0 0.0 -0.29 1.0 1.0 SEC6/SEC8 0.015 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.034 0.12 0.418 3.0 -0.3 54.0 57.0 HGF/MET -0.011 0.133 -9999.0 0.0 -0.306 57.0 57.0 HGF -0.031 0.164 -9999.0 0.0 -0.437 47.0 47.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.029 -9999.0 0.0 -0.276 3.0 3.0 actin cable formation 0.071 0.136 0.507 22.0 -0.331 1.0 23.0 KIAA1543 0.013 0.06 0.373 6.0 -0.287 4.0 10.0 KIFC3 0.023 0.024 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.029 0.004 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.026 0.039 0.358 3.0 -9999.0 0.0 3.0 NCK1/GIT1 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.058 0.019 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.024 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.054 0.413 6.0 -9999.0 0.0 6.0 LIMA1 0.025 0.044 -9999.0 0.0 -0.577 2.0 2.0 ABI1 0.029 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.048 0.109 0.462 17.0 -9999.0 0.0 17.0 adherens junction assembly 0.028 0.096 0.508 9.0 -9999.0 0.0 9.0 IGF-1R heterotetramer/IGF1 0.006 0.096 -9999.0 0.0 -0.29 22.0 22.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.03 0.178 -9999.0 0.0 -0.577 36.0 36.0 PLEKHA7 0.026 0.061 0.383 6.0 -0.3 4.0 10.0 mol:GTP 0.062 0.034 -9999.0 0.0 -0.329 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.033 0.065 0.507 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.029 0.029 -9999.0 0.0 -0.274 3.0 3.0 regulation of cell-cell adhesion 0.024 0.059 0.416 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.029 -9999.0 0.0 -0.276 3.0 3.0