Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.086 0.158 -9999.0 0.0 -0.526 4.0 4.0 IHH -0.048 0.131 -9999.0 0.0 -0.307 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.039 0.085 -9999.0 0.0 -0.178 14.0 14.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.039 0.085 0.177 14.0 -9999.0 0.0 14.0 SMO/beta Arrestin2 -0.1 0.18 -9999.0 0.0 -0.338 14.0 14.0 SMO -0.114 0.178 -9999.0 0.0 -0.347 15.0 15.0 AKT1 -0.057 0.148 -9999.0 0.0 -0.485 4.0 4.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 STIL -0.061 0.136 0.19 2.0 -0.286 9.0 11.0 DHH N/PTCH2 0.04 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 -0.063 0.124 -9999.0 0.0 -0.211 20.0 20.0 PIK3CA 0.019 0.05 -9999.0 0.0 -0.341 1.0 1.0 DHH 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.124 0.193 -9999.0 0.0 -0.51 6.0 6.0 determination of left/right symmetry -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 PIK3R1 -0.007 0.098 -9999.0 0.0 -0.341 4.0 4.0 skeletal system development -0.123 0.192 -9999.0 0.0 -0.506 6.0 6.0 IHH N/Hhip -0.1 0.137 -9999.0 0.0 -0.254 21.0 21.0 DHH N/Hhip 0.0 0.088 -9999.0 0.0 -0.237 6.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 pancreas development -0.023 0.116 -9999.0 0.0 -0.34 6.0 6.0 HHAT -0.026 0.123 -9999.0 0.0 -0.341 7.0 7.0 PI3K 0.013 0.083 -9999.0 0.0 -0.302 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.047 0.135 -9999.0 0.0 -0.341 9.0 9.0 somite specification -0.112 0.176 -9999.0 0.0 -0.349 14.0 14.0 SHH Np/Cholesterol/PTCH1 -0.075 0.129 -9999.0 0.0 -0.268 12.0 12.0 SHH Np/Cholesterol/PTCH2 -0.005 0.068 -9999.0 0.0 -0.176 7.0 7.0 SHH Np/Cholesterol/Megalin -0.008 0.068 -9999.0 0.0 -0.179 7.0 7.0 SHH -0.018 0.078 -9999.0 0.0 -0.237 6.0 6.0 catabolic process -0.075 0.128 -9999.0 0.0 -0.239 19.0 19.0 SMO/Vitamin D3 -0.077 0.172 -9999.0 0.0 -0.302 16.0 16.0 SHH Np/Cholesterol/Hhip -0.029 0.087 -9999.0 0.0 -0.19 11.0 11.0 LRP2 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.078 0.168 -9999.0 0.0 -0.402 7.0 7.0 SHH Np/Cholesterol/BOC -0.005 0.064 -9999.0 0.0 -0.179 6.0 6.0 SHH Np/Cholesterol/CDO -0.007 0.068 -9999.0 0.0 -0.179 7.0 7.0 mesenchymal cell differentiation 0.029 0.087 0.189 11.0 -9999.0 0.0 11.0 mol:Vitamin D3 -0.054 0.152 0.21 2.0 -0.278 11.0 13.0 IHH N/PTCH2 -0.062 0.11 -9999.0 0.0 -0.215 17.0 17.0 CDON 0.023 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.08 0.134 -9999.0 0.0 -0.238 21.0 21.0 Megalin/LRPAP1 0.033 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.012 0.064 -9999.0 0.0 -0.174 7.0 7.0 PTCH1 -0.076 0.129 -9999.0 0.0 -0.24 19.0 19.0 HHIP -0.023 0.116 -9999.0 0.0 -0.341 6.0 6.0