Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	8.0	422.0	52.0	-0.124	0.04	1000.0	-1000.0	-0.017	-1000.0
HIF-1-alpha transcription factor network	8.0	624.0	76.0	-0.191	0.031	1000.0	-1000.0	-0.016	-1000.0
Ephrin B reverse signaling	8.0	410.0	48.0	-0.222	0.028	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	7.0	565.0	78.0	-0.231	0.087	1000.0	-1000.0	-0.045	-1000.0
PLK2 and PLK4 events	6.0	20.0	3.0	-0.047	0.02	1000.0	-1000.0	-0.0	-1000.0
IGF1 pathway	6.0	372.0	57.0	-0.063	0.046	1000.0	-1000.0	-0.021	-1000.0
FOXM1 transcription factor network	6.0	346.0	51.0	-0.433	0.027	1000.0	-1000.0	-0.089	-1000.0
Osteopontin-mediated events	5.0	198.0	38.0	-0.095	0.028	1000.0	-1000.0	-0.021	-1000.0
Noncanonical Wnt signaling pathway	5.0	145.0	26.0	-0.071	0.027	1000.0	-1000.0	-0.029	-1000.0
Glypican 1 network	5.0	278.0	48.0	-0.058	0.03	1000.0	-1000.0	-0.018	-1000.0
Nectin adhesion pathway	5.0	358.0	63.0	-0.082	0.057	1000.0	-1000.0	-0.022	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	5.0	364.0	68.0	-0.205	0.117	1000.0	-1000.0	-0.043	-1000.0
TCGA08_retinoblastoma	5.0	47.0	8.0	-0.036	0.023	1000.0	-1000.0	-0.002	-1000.0
Plasma membrane estrogen receptor signaling	5.0	514.0	86.0	-0.167	0.157	1000.0	-1000.0	-0.03	-1000.0
IL12-mediated signaling events	4.0	377.0	87.0	-0.26	0.048	1000.0	-1000.0	-0.043	-1000.0
Syndecan-1-mediated signaling events	4.0	138.0	34.0	-0.079	0.037	1000.0	-1000.0	-0.021	-1000.0
IL4-mediated signaling events	4.0	421.0	91.0	-0.554	0.356	1000.0	-1000.0	-0.067	-1000.0
Endothelins	4.0	479.0	96.0	-0.149	0.033	1000.0	-1000.0	-0.037	-1000.0
Signaling mediated by p38-alpha and p38-beta	4.0	180.0	44.0	-0.067	0.028	1000.0	-1000.0	-0.012	-1000.0
EPHB forward signaling	4.0	341.0	85.0	-0.072	0.047	1000.0	-1000.0	-0.043	-1000.0
Wnt signaling	4.0	32.0	7.0	-0.065	0.024	1000.0	-1000.0	-0.005	-1000.0
IL23-mediated signaling events	4.0	243.0	60.0	-0.306	0.028	1000.0	-1000.0	-0.065	-1000.0
Caspase cascade in apoptosis	3.0	223.0	74.0	-0.036	0.038	1000.0	-1000.0	-0.027	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	499.0	136.0	-0.412	0.074	1000.0	-1000.0	-0.03	-1000.0
Thromboxane A2 receptor signaling	3.0	330.0	105.0	-0.075	0.05	1000.0	-1000.0	-0.029	-1000.0
FOXA2 and FOXA3 transcription factor networks	3.0	140.0	46.0	-0.169	0.038	1000.0	-1000.0	-0.058	-1000.0
BMP receptor signaling	3.0	282.0	81.0	-0.1	0.047	1000.0	-1000.0	-0.021	-1000.0
Fc-epsilon receptor I signaling in mast cells	3.0	300.0	97.0	-0.064	0.046	1000.0	-1000.0	-0.037	-1000.0
Reelin signaling pathway	3.0	179.0	56.0	-0.049	0.05	1000.0	-1000.0	-0.017	-1000.0
TCGA08_p53	3.0	21.0	7.0	-0.035	0.022	1000.0	-1000.0	-0.002	-1000.0
FAS signaling pathway (CD95)	3.0	179.0	47.0	-0.083	0.034	1000.0	-1000.0	-0.025	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	292.0	93.0	-0.057	0.037	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	153.0	45.0	-0.031	0.048	1000.0	-1000.0	-0.03	-1000.0
Glypican 2 network	3.0	15.0	4.0	-0.01	0.0	1000.0	-1000.0	0.0	-1000.0
Nongenotropic Androgen signaling	3.0	191.0	52.0	-0.1	0.048	1000.0	-1000.0	-0.017	-1000.0
IL27-mediated signaling events	3.0	160.0	51.0	-0.094	0.047	1000.0	-1000.0	-0.03	-1000.0
LPA receptor mediated events	3.0	321.0	102.0	-0.104	0.028	1000.0	-1000.0	-0.041	-1000.0
Syndecan-4-mediated signaling events	3.0	210.0	67.0	-0.06	0.038	1000.0	-1000.0	-0.024	-1000.0
VEGFR1 specific signals	3.0	200.0	56.0	-0.048	0.028	1000.0	-1000.0	-0.029	-1000.0
Regulation of Androgen receptor activity	3.0	218.0	70.0	-0.143	0.034	1000.0	-1000.0	-0.032	-1000.0
Coregulation of Androgen receptor activity	2.0	210.0	76.0	-0.133	0.047	1000.0	-1000.0	-0.014	-1000.0
Visual signal transduction: Cones	2.0	82.0	38.0	-0.014	0.043	1000.0	-1000.0	-0.0	-1000.0
JNK signaling in the CD4+ TCR pathway	2.0	34.0	17.0	-0.032	0.048	1000.0	-1000.0	-0.016	-1000.0
Syndecan-2-mediated signaling events	2.0	146.0	69.0	-0.035	0.04	1000.0	-1000.0	-0.02	-1000.0
Cellular roles of Anthrax toxin	2.0	105.0	39.0	-0.056	0.027	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by PTP1B	2.0	185.0	76.0	-0.07	0.047	1000.0	-1000.0	-0.028	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	179.0	65.0	-0.317	0.066	1000.0	-1000.0	-0.023	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	155.0	61.0	-0.083	0.051	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	2.0	111.0	55.0	-0.075	0.048	1000.0	-1000.0	-0.021	-1000.0
PLK1 signaling events	2.0	219.0	85.0	-0.044	0.029	1000.0	-1000.0	-0.032	-1000.0
PDGFR-alpha signaling pathway	2.0	114.0	44.0	-0.131	0.038	1000.0	-1000.0	-0.029	-1000.0
mTOR signaling pathway	2.0	114.0	53.0	-0.019	0.034	1000.0	-1000.0	-0.029	-1000.0
IFN-gamma pathway	2.0	170.0	68.0	-0.049	0.039	1000.0	-1000.0	-0.029	-1000.0
Glucocorticoid receptor regulatory network	2.0	233.0	114.0	-0.13	0.072	1000.0	-1000.0	-0.041	-1000.0
TRAIL signaling pathway	2.0	107.0	48.0	-0.014	0.037	1000.0	-1000.0	-0.021	-1000.0
IL1-mediated signaling events	2.0	168.0	62.0	-0.042	0.043	1000.0	-1000.0	-0.018	-1000.0
S1P5 pathway	2.0	40.0	17.0	-0.024	0.027	1000.0	-1000.0	-0.004	-1000.0
ceramide signaling pathway	2.0	136.0	49.0	-0.025	0.04	1000.0	-1000.0	-0.021	-1000.0
HIF-2-alpha transcription factor network	2.0	106.0	43.0	-0.049	0.049	1000.0	-1000.0	-0.033	-1000.0
S1P1 pathway	2.0	93.0	36.0	-0.102	0.026	1000.0	-1000.0	-0.014	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	37.0	15.0	-0.025	0.026	1000.0	-1000.0	-0.024	-1000.0
Retinoic acid receptors-mediated signaling	2.0	160.0	58.0	-0.105	0.054	1000.0	-1000.0	-0.031	-1000.0
Syndecan-3-mediated signaling events	2.0	72.0	35.0	-0.055	0.05	1000.0	-1000.0	-0.013	-1000.0
IL2 signaling events mediated by PI3K	2.0	123.0	58.0	-0.1	0.028	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	2.0	247.0	84.0	-0.075	0.055	1000.0	-1000.0	-0.018	-1000.0
Canonical Wnt signaling pathway	2.0	147.0	51.0	-0.083	0.067	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	266.0	125.0	-0.031	0.045	1000.0	-1000.0	-0.021	-1000.0
IL6-mediated signaling events	2.0	201.0	75.0	-0.077	0.073	1000.0	-1000.0	-0.041	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	172.0	74.0	-0.054	0.049	1000.0	-1000.0	-0.05	-1000.0
IL2 signaling events mediated by STAT5	2.0	48.0	22.0	-0.067	0.035	1000.0	-1000.0	-0.022	-1000.0
Class I PI3K signaling events	2.0	167.0	73.0	-0.029	0.045	1000.0	-1000.0	-0.016	-1000.0
BCR signaling pathway	2.0	254.0	99.0	-0.048	0.053	1000.0	-1000.0	-0.03	-1000.0
Visual signal transduction: Rods	2.0	109.0	52.0	-0.076	0.061	1000.0	-1000.0	-0.015	-1000.0
E-cadherin signaling in keratinocytes	2.0	101.0	43.0	-0.032	0.041	1000.0	-1000.0	-0.021	-1000.0
Ras signaling in the CD4+ TCR pathway	2.0	37.0	17.0	-0.014	0.043	1000.0	-1000.0	-0.013	-1000.0
Aurora B signaling	2.0	154.0	67.0	-0.073	0.043	1000.0	-1000.0	-0.027	-1000.0
LPA4-mediated signaling events	1.0	20.0	12.0	-0.023	0.002	1000.0	-1000.0	-0.016	-1000.0
ErbB2/ErbB3 signaling events	1.0	79.0	65.0	-0.038	0.067	1000.0	-1000.0	-0.035	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	25.0	23.0	-0.003	0.037	1000.0	-1000.0	-0.017	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	1.0	61.0	34.0	-0.023	0.059	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	1.0	41.0	39.0	-0.017	0.063	1000.0	-1000.0	-0.017	-1000.0
BARD1 signaling events	1.0	59.0	57.0	-0.049	0.065	1000.0	-1000.0	-0.028	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	31.0	28.0	-0.024	0.038	1000.0	-1000.0	-0.012	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	74.0	54.0	-0.034	0.039	1000.0	-1000.0	-0.015	-1000.0
Ephrin A  reverse signaling	1.0	8.0	7.0	-0.0	0.032	1000.0	-1000.0	-0.0	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	7.0	5.0	0.011	0.026	1000.0	-1000.0	0.015	-1000.0
Arf6 signaling events	1.0	112.0	62.0	-0.009	0.043	1000.0	-1000.0	-0.005	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	127.0	85.0	-0.129	0.051	1000.0	-1000.0	-0.031	-1000.0
Aurora A signaling	1.0	93.0	60.0	-0.022	0.047	1000.0	-1000.0	-0.009	-1000.0
p75(NTR)-mediated signaling	1.0	247.0	125.0	-0.085	0.061	1000.0	-1000.0	-0.037	-1000.0
amb2 Integrin signaling	1.0	150.0	82.0	-0.025	0.063	1000.0	-1000.0	-0.018	-1000.0
Ceramide signaling pathway	1.0	138.0	76.0	-0.045	0.063	1000.0	-1000.0	-0.011	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	1.0	58.0	37.0	-0.023	0.046	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class III	1.0	70.0	40.0	-0.051	0.052	1000.0	-1000.0	-0.03	-1000.0
Signaling events regulated by Ret tyrosine kinase	1.0	89.0	82.0	-0.018	0.048	1000.0	-1000.0	-0.033	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	1.0	94.0	52.0	-0.052	0.064	1000.0	-1000.0	-0.024	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	116.0	83.0	-0.026	0.056	1000.0	-1000.0	-0.016	-1000.0
FoxO family signaling	1.0	70.0	64.0	-0.037	0.041	1000.0	-1000.0	-0.035	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	57.0	36.0	-0.034	0.041	1000.0	-1000.0	-0.021	-1000.0
Atypical NF-kappaB pathway	1.0	40.0	31.0	-0.007	0.028	1000.0	-1000.0	-0.005	-1000.0
Regulation of p38-alpha and p38-beta	1.0	64.0	54.0	-0.045	0.058	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	1.0	47.0	31.0	-0.027	0.034	1000.0	-1000.0	-0.024	-1000.0
TCGA08_rtk_signaling	1.0	41.0	26.0	-0.056	0.064	1000.0	-1000.0	-0.014	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	117.0	76.0	-0.026	0.053	1000.0	-1000.0	-0.036	-1000.0
Regulation of Telomerase	1.0	126.0	102.0	-0.065	0.056	1000.0	-1000.0	-0.026	-1000.0
EGFR-dependent Endothelin signaling events	1.0	30.0	21.0	-0.015	0.041	1000.0	-1000.0	-0.027	-1000.0
Insulin Pathway	1.0	129.0	74.0	-0.042	0.058	1000.0	-1000.0	-0.025	-1000.0
S1P3 pathway	1.0	65.0	42.0	-0.03	0.038	1000.0	-1000.0	-0.017	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	163.0	120.0	-0.046	0.075	1000.0	-1000.0	-0.028	-1000.0
PDGFR-beta signaling pathway	1.0	161.0	97.0	-0.025	0.061	1000.0	-1000.0	-0.028	-1000.0
S1P4 pathway	1.0	42.0	25.0	-0.026	0.038	1000.0	-1000.0	-0.012	-1000.0
E-cadherin signaling events	1.0	6.0	5.0	0.014	0.041	1000.0	-1000.0	0.012	-1000.0
p38 MAPK signaling pathway	1.0	55.0	44.0	-0.032	0.048	1000.0	-1000.0	-0.011	-1000.0
Signaling events mediated by HDAC Class II	0.0	63.0	75.0	-0.065	0.069	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	0.0	39.0	69.0	-0.031	0.056	1000.0	-1000.0	-0.017	-1000.0
Circadian rhythm pathway	0.0	6.0	22.0	-0.01	0.058	1000.0	-1000.0	-0.022	-1000.0
Arf6 downstream pathway	0.0	34.0	43.0	-0.041	0.045	1000.0	-1000.0	-0.024	-1000.0
Aurora C signaling	0.0	5.0	7.0	-0.0	0.037	1000.0	-1000.0	-0.007	-1000.0
Insulin-mediated glucose transport	0.0	23.0	32.0	-0.002	0.05	1000.0	-1000.0	-0.014	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	60.0	68.0	-0.039	0.047	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	0.0	85.0	104.0	-0.037	0.064	1000.0	-1000.0	-0.025	-1000.0
Effects of Botulinum toxin	0.0	9.0	26.0	-0.001	0.046	1000.0	-1000.0	-0.001	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	17.0	27.0	-0.0	0.064	1000.0	-1000.0	-0.019	-1000.0
Arf6 trafficking events	0.0	18.0	71.0	-0.039	0.049	1000.0	-1000.0	-0.02	-1000.0
Angiopoietin receptor Tie2-mediated signaling	0.0	87.0	88.0	-0.042	0.046	1000.0	-1000.0	-0.052	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	24.0	33.0	-0.042	0.066	1000.0	-1000.0	-0.022	-1000.0
Rapid glucocorticoid signaling	0.0	8.0	20.0	-0.003	0.034	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by PRL	0.0	27.0	34.0	-0.031	0.041	1000.0	-1000.0	-0.026	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.027	0.027	1000.0	-1000.0	-0.017	-1000.0
Arf1 pathway	0.0	17.0	54.0	-0.001	0.05	1000.0	-1000.0	-0.012	-1000.0
Alternative NF-kappaB pathway	0.0	3.0	13.0	0.0	0.067	1000.0	-1000.0	0.0	-1000.0
Total	279	19226	7203	-9.23453593802	6.35135845623	131000	-131000	-3.03269576149	-131000