E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.007 0.093 -9999.0 0.0 -0.342 7.0 7.0 KLHL20 -0.003 0.07 -9999.0 0.0 -0.241 12.0 12.0 CYFIP2 0.018 0.057 -9999.0 0.0 -0.438 4.0 4.0 Rac1/GDP 0.009 0.065 -9999.0 0.0 -0.279 3.0 3.0 ENAH -0.013 0.095 -9999.0 0.0 -0.367 6.0 6.0 AP1M1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.021 0.041 -9999.0 0.0 -0.438 2.0 2.0 CDC42/GTP 0.021 0.036 -9999.0 0.0 -0.206 1.0 1.0 ABI1/Sra1/Nap1 -0.018 0.043 -9999.0 0.0 -0.161 12.0 12.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.056 -9999.0 0.0 -0.237 8.0 8.0 RAPGEF1 -0.003 0.077 -9999.0 0.0 -0.347 4.0 4.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.002 0.1 -9999.0 0.0 -0.281 26.0 26.0 CRK -0.004 0.078 -9999.0 0.0 -0.372 4.0 4.0 E-cadherin/gamma catenin/alpha catenin 0.041 0.037 -9999.0 0.0 -0.264 3.0 3.0 alphaE/beta7 Integrin 0.028 0.049 -9999.0 0.0 -0.312 5.0 5.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.005 0.089 -9999.0 0.0 -0.319 7.0 7.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.0 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.037 0.048 -9999.0 0.0 -0.235 7.0 7.0 PI3K 0.005 0.033 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.021 0.041 -9999.0 0.0 -0.438 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.029 0.039 -9999.0 0.0 -0.312 3.0 3.0 TIAM1 0.015 0.065 -9999.0 0.0 -0.438 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.05 0.036 -9999.0 0.0 -0.225 3.0 3.0 AKT1 0.004 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.002 0.094 -9999.0 0.0 -0.438 11.0 11.0 CDH1 0.021 0.03 -9999.0 0.0 -0.438 1.0 1.0 RhoA/GDP 0.01 0.065 -9999.0 0.0 -0.265 4.0 4.0 actin cytoskeleton organization 0.0 0.055 0.172 2.0 -0.174 12.0 14.0 CDC42/GDP 0.011 0.067 -9999.0 0.0 -0.27 5.0 5.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.015 0.026 -9999.0 0.0 -0.218 3.0 3.0 ITGB7 0.015 0.064 -9999.0 0.0 -0.438 5.0 5.0 RAC1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.054 0.038 -9999.0 0.0 -0.24 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.037 0.032 -9999.0 0.0 -0.223 3.0 3.0 mol:GDP -0.003 0.07 -9999.0 0.0 -0.297 5.0 5.0 CDC42/GTP/IQGAP1 0.031 0.02 -9999.0 0.0 -0.262 1.0 1.0 JUP 0.02 0.041 -9999.0 0.0 -0.438 2.0 2.0 p120 catenin/RhoA/GDP 0.017 0.068 -9999.0 0.0 -0.271 4.0 4.0 RAC1/GTP/IQGAP1 0.032 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.034 0.011 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.029 -9999.0 0.0 -0.438 1.0 1.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.001 0.054 0.14 3.0 -0.189 12.0 15.0 NME1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.001 0.087 -9999.0 0.0 -0.395 4.0 4.0 regulation of cell-cell adhesion 0.014 0.03 -9999.0 0.0 -0.183 1.0 1.0 WASF2 0.002 0.029 -9999.0 0.0 -0.114 2.0 2.0 Rap1/GTP 0.027 0.042 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.055 0.057 -9999.0 0.0 -0.224 8.0 8.0 CCND1 0.0 0.066 0.16 3.0 -0.235 12.0 15.0 VAV2 -0.024 0.163 -9999.0 0.0 -0.572 15.0 15.0 RAP1/GDP 0.025 0.056 -9999.0 0.0 -0.326 1.0 1.0 adherens junction assembly -0.001 0.084 -9999.0 0.0 -0.383 4.0 4.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.04 0.057 -9999.0 0.0 -0.216 10.0 10.0 E-cadherin/beta catenin 0.011 0.022 -9999.0 0.0 -0.323 1.0 1.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.006 0.093 -9999.0 0.0 -0.34 8.0 8.0 PIK3CA 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.022 0.108 -9999.0 0.0 -0.373 15.0 15.0 E-cadherin/beta catenin/alpha catenin 0.042 0.037 -9999.0 0.0 -0.264 3.0 3.0 ITGAE 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.101 -9999.0 0.0 -0.286 26.0 26.0