Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.003 0.089 0.32 17.0 -9999.0 0.0 17.0 KIRREL -0.013 0.117 -9999.0 0.0 -0.444 17.0 17.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.003 0.089 -9999.0 0.0 -0.32 17.0 17.0 PLCG1 0.023 0.029 -9999.0 0.0 -0.438 1.0 1.0 ARRB2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.001 0.092 -9999.0 0.0 -0.246 29.0 29.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.001 0.065 -9999.0 0.0 -0.236 17.0 17.0 FYN 0.019 0.082 0.143 44.0 -0.224 17.0 61.0 mol:Ca2+ 0.013 0.074 -9999.0 0.0 -0.245 17.0 17.0 mol:DAG 0.013 0.075 -9999.0 0.0 -0.246 17.0 17.0 NPHS2 -0.003 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.013 0.075 -9999.0 0.0 -0.246 17.0 17.0 regulation of endocytosis 0.018 0.066 -9999.0 0.0 -0.212 17.0 17.0 Nephrin/NEPH1/podocin/Cholesterol 0.005 0.066 -9999.0 0.0 -0.232 17.0 17.0 establishment of cell polarity 0.003 0.089 -9999.0 0.0 -0.32 17.0 17.0 Nephrin/NEPH1/podocin/NCK1-2 0.026 0.073 -9999.0 0.0 -0.226 17.0 17.0 Nephrin/NEPH1/beta Arrestin2 0.022 0.067 -9999.0 0.0 -0.214 17.0 17.0 NPHS1 0.021 0.035 -9999.0 0.0 -0.401 1.0 1.0 Nephrin/NEPH1/podocin 0.006 0.064 -9999.0 0.0 -0.225 17.0 17.0 TJP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.023 0.029 -9999.0 0.0 -0.438 1.0 1.0 NCK2 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.014 0.075 -9999.0 0.0 -0.247 17.0 17.0 CD2AP 0.001 0.101 -9999.0 0.0 -0.438 13.0 13.0 Nephrin/NEPH1/podocin/GRB2 0.015 0.071 -9999.0 0.0 -0.233 17.0 17.0 GRB2 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.014 0.09 0.15 40.0 -0.227 20.0 60.0 cytoskeleton organization -0.005 0.074 0.195 5.0 -0.256 17.0 22.0 Nephrin/NEPH1 0.006 0.063 -9999.0 0.0 -0.219 17.0 17.0 Nephrin/NEPH1/ZO-1 0.015 0.076 -9999.0 0.0 -0.253 17.0 17.0