Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.099 0.203 -9999.0 0.0 -0.641 23.0 23.0 IHH -0.153 0.228 -9999.0 0.0 -0.477 82.0 82.0 SHH Np/Cholesterol/GAS1 -0.05 0.116 -9999.0 0.0 -0.267 53.0 53.0 LRPAP1 0.019 0.05 -9999.0 0.0 -0.438 3.0 3.0 dorsoventral neural tube patterning 0.05 0.116 0.266 53.0 -9999.0 0.0 53.0 SMO/beta Arrestin2 -0.109 0.219 -9999.0 0.0 -0.408 70.0 70.0 SMO -0.13 0.217 -9999.0 0.0 -0.424 73.0 73.0 AKT1 -0.056 0.167 -9999.0 0.0 -0.515 20.0 20.0 ARRB2 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.013 0.055 -9999.0 0.0 -0.438 3.0 3.0 ADRBK1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.213 -9999.0 0.0 -0.417 73.0 73.0 STIL -0.09 0.19 -9999.0 0.0 -0.392 48.0 48.0 DHH N/PTCH2 0.002 0.109 -9999.0 0.0 -0.349 21.0 21.0 DHH N/PTCH1 -0.091 0.181 -9999.0 0.0 -0.303 88.0 88.0 PIK3CA 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.004 0.108 -9999.0 0.0 -0.438 15.0 15.0 PTHLH -0.132 0.254 -9999.0 0.0 -0.686 29.0 29.0 determination of left/right symmetry -0.129 0.213 -9999.0 0.0 -0.417 73.0 73.0 PIK3R1 0.002 0.094 -9999.0 0.0 -0.438 11.0 11.0 skeletal system development -0.131 0.251 -9999.0 0.0 -0.678 29.0 29.0 IHH N/Hhip -0.133 0.199 -9999.0 0.0 -0.366 97.0 97.0 DHH N/Hhip -0.045 0.146 -9999.0 0.0 -0.324 54.0 54.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.213 -9999.0 0.0 -0.417 73.0 73.0 pancreas development -0.055 0.168 -9999.0 0.0 -0.437 41.0 41.0 HHAT 0.002 0.093 -9999.0 0.0 -0.438 11.0 11.0 PI3K 0.025 0.051 -9999.0 0.0 -0.312 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.025 0.125 -9999.0 0.0 -0.438 20.0 20.0 somite specification -0.129 0.213 -9999.0 0.0 -0.417 73.0 73.0 SHH Np/Cholesterol/PTCH1 -0.112 0.182 -9999.0 0.0 -0.382 58.0 58.0 SHH Np/Cholesterol/PTCH2 -0.036 0.107 -9999.0 0.0 -0.259 44.0 44.0 SHH Np/Cholesterol/Megalin -0.069 0.124 -9999.0 0.0 -0.271 63.0 63.0 SHH -0.051 0.124 -9999.0 0.0 -0.325 42.0 42.0 catabolic process -0.097 0.178 -9999.0 0.0 -0.316 89.0 89.0 SMO/Vitamin D3 -0.108 0.227 -9999.0 0.0 -0.398 74.0 74.0 SHH Np/Cholesterol/Hhip -0.066 0.14 -9999.0 0.0 -0.298 62.0 62.0 LRP2 -0.064 0.155 -9999.0 0.0 -0.438 35.0 35.0 receptor-mediated endocytosis -0.141 0.228 -9999.0 0.0 -0.495 51.0 51.0 SHH Np/Cholesterol/BOC -0.034 0.104 -9999.0 0.0 -0.258 42.0 42.0 SHH Np/Cholesterol/CDO -0.033 0.106 -9999.0 0.0 -0.261 42.0 42.0 mesenchymal cell differentiation 0.066 0.139 0.296 62.0 -9999.0 0.0 62.0 mol:Vitamin D3 -0.089 0.207 0.37 1.0 -0.4 53.0 54.0 IHH N/PTCH2 -0.086 0.155 -9999.0 0.0 -0.301 82.0 82.0 CDON 0.019 0.043 -9999.0 0.0 -0.438 2.0 2.0 IHH N/PTCH1 -0.091 0.184 -9999.0 0.0 -0.319 89.0 89.0 Megalin/LRPAP1 -0.036 0.123 -9999.0 0.0 -0.319 37.0 37.0 PTCH2 0.007 0.086 -9999.0 0.0 -0.438 9.0 9.0 SHH Np/Cholesterol -0.036 0.097 -9999.0 0.0 -0.247 42.0 42.0 PTCH1 -0.097 0.178 -9999.0 0.0 -0.317 89.0 89.0 HHIP -0.055 0.168 -9999.0 0.0 -0.438 41.0 41.0