Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.019 0.034 -9999.0 0.0 -0.243 4.0 4.0 epithelial cell differentiation 0.045 0.034 -9999.0 0.0 -0.223 3.0 3.0 CYFIP2 0.018 0.057 -9999.0 0.0 -0.438 4.0 4.0 ENAH -0.005 0.059 0.255 4.0 -0.389 1.0 5.0 EGFR 0.014 0.07 -9999.0 0.0 -0.438 6.0 6.0 EPHA2 0.015 0.064 -9999.0 0.0 -0.438 5.0 5.0 MYO6 0.01 0.03 0.178 1.0 -0.216 4.0 5.0 CTNNB1 0.021 0.041 -9999.0 0.0 -0.438 2.0 2.0 ABI1/Sra1/Nap1 0.044 0.037 -9999.0 0.0 -0.264 3.0 3.0 AQP5 -0.04 0.144 -9999.0 0.0 -0.427 30.0 30.0 CTNND1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.01 0.024 -9999.0 0.0 -0.212 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.072 0.177 1.0 -0.212 29.0 30.0 EGF -0.023 0.122 -9999.0 0.0 -0.438 19.0 19.0 NCKAP1 0.025 0.003 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.019 0.119 -9999.0 0.0 -0.43 19.0 19.0 cortical microtubule organization 0.045 0.034 -9999.0 0.0 -0.223 3.0 3.0 GO:0000145 -0.007 0.022 -9999.0 0.0 -0.203 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.05 0.036 -9999.0 0.0 -0.225 3.0 3.0 MLLT4 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.016 0.052 -9999.0 0.0 -0.694 1.0 1.0 ARF6 0.021 0.041 -9999.0 0.0 -0.438 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.039 0.059 -9999.0 0.0 -0.276 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.007 0.022 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.011 0.027 -9999.0 0.0 -0.215 3.0 3.0 ARF6/GTP 0.043 0.066 -9999.0 0.0 -0.292 6.0 6.0 CDH1 0.021 0.03 -9999.0 0.0 -0.438 1.0 1.0 EGFR/EGFR/EGF/EGF 0.008 0.088 -9999.0 0.0 -0.235 25.0 25.0 RhoA/GDP 0.046 0.034 -9999.0 0.0 -0.213 3.0 3.0 actin cytoskeleton organization -0.008 0.026 -9999.0 0.0 -0.209 4.0 4.0 IGF-1R heterotetramer 0.001 0.101 -9999.0 0.0 -0.437 13.0 13.0 GIT1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.001 0.101 -9999.0 0.0 -0.438 13.0 13.0 IGF1 -0.013 0.116 -9999.0 0.0 -0.438 17.0 17.0 DIAPH1 0.014 0.122 -9999.0 0.0 -0.527 8.0 8.0 Wnt receptor signaling pathway -0.045 0.034 0.223 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.015 0.045 -9999.0 0.0 -0.538 1.0 1.0 CTNNA1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.008 0.026 -9999.0 0.0 -0.213 4.0 4.0 EFNA1 0.017 0.041 -9999.0 0.0 -0.438 2.0 2.0 LPP -0.007 0.022 0.172 1.0 -0.207 2.0 3.0 Ephrin A1/EPHA2 0.025 0.054 -9999.0 0.0 -0.235 8.0 8.0 SEC6/SEC8 0.01 0.024 -9999.0 0.0 -0.202 3.0 3.0 MGAT3 -0.014 0.073 0.178 1.0 -0.215 29.0 30.0 HGF/MET 0.011 0.085 -9999.0 0.0 -0.226 25.0 25.0 HGF -0.003 0.102 -9999.0 0.0 -0.438 13.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.019 0.035 -9999.0 0.0 -0.244 4.0 4.0 actin cable formation 0.051 0.105 0.229 49.0 -0.272 3.0 52.0 KIAA1543 -0.006 0.027 0.167 2.0 -0.205 3.0 5.0 KIFC3 0.007 0.036 -9999.0 0.0 -0.216 6.0 6.0 NCK1 0.023 0.029 -9999.0 0.0 -0.438 1.0 1.0 EXOC3 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.01 0.03 0.178 1.0 -0.216 4.0 5.0 NCK1/GIT1 0.033 0.024 -9999.0 0.0 -0.312 1.0 1.0 mol:GDP 0.045 0.034 -9999.0 0.0 -0.223 3.0 3.0 EXOC4 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.011 0.029 0.178 2.0 -0.215 3.0 5.0 PIP5K1C 0.01 0.025 -9999.0 0.0 -0.215 3.0 3.0 LIMA1 0.023 0.029 -9999.0 0.0 -0.438 1.0 1.0 ABI1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.024 0.092 0.311 7.0 -0.465 1.0 8.0 adherens junction assembly -0.023 0.108 -9999.0 0.0 -0.491 9.0 9.0 IGF-1R heterotetramer/IGF1 0.006 0.087 -9999.0 0.0 -0.216 31.0 31.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.001 0.102 -9999.0 0.0 -0.438 13.0 13.0 PLEKHA7 0.012 0.029 0.178 2.0 -0.215 3.0 5.0 mol:GTP 0.038 0.058 -9999.0 0.0 -0.274 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.004 0.065 0.367 4.0 -9999.0 0.0 4.0 cortical actin cytoskeleton stabilization 0.019 0.034 -9999.0 0.0 -0.243 4.0 4.0 regulation of cell-cell adhesion -0.008 0.026 -9999.0 0.0 -0.209 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.019 0.035 -9999.0 0.0 -0.244 4.0 4.0