Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	43.0	2250.0	52.0	-0.153	0.066	1000.0	-1000.0	-0.024	-1000.0
IL4-mediated signaling events	37.0	3385.0	91.0	-0.598	0.468	1000.0	-1000.0	-0.088	-1000.0
Signaling mediated by p38-alpha and p38-beta	35.0	1545.0	44.0	-0.125	0.025	1000.0	-1000.0	-0.015	-1000.0
IL23-mediated signaling events	30.0	1813.0	60.0	-0.389	0.024	1000.0	-1000.0	-0.092	-1000.0
EPHB forward signaling	29.0	2489.0	85.0	-0.084	0.069	1000.0	-1000.0	-0.046	-1000.0
HIF-1-alpha transcription factor network	27.0	2068.0	76.0	-0.196	0.037	1000.0	-1000.0	-0.056	-1000.0
Syndecan-1-mediated signaling events	26.0	884.0	34.0	-0.109	0.024	1000.0	-1000.0	-0.028	-1000.0
Ephrin A  reverse signaling	25.0	175.0	7.0	-0.041	0.015	1000.0	-1000.0	-0.0	-1000.0
Noncanonical Wnt signaling pathway	25.0	664.0	26.0	-0.082	0.025	1000.0	-1000.0	-0.032	-1000.0
TCR signaling in naïve CD8+ T cells	25.0	2377.0	93.0	-0.095	0.035	1000.0	-1000.0	-0.037	-1000.0
Ephrin B reverse signaling	24.0	1198.0	48.0	-0.089	0.025	1000.0	-1000.0	-0.024	-1000.0
Wnt signaling	24.0	169.0	7.0	-0.082	0.02	1000.0	-1000.0	-0.014	-1000.0
Glucocorticoid receptor regulatory network	23.0	2700.0	114.0	-0.386	0.195	1000.0	-1000.0	-0.041	-1000.0
Endothelins	23.0	2225.0	96.0	-0.12	0.047	1000.0	-1000.0	-0.046	-1000.0
FOXA2 and FOXA3 transcription factor networks	21.0	1010.0	46.0	-0.277	0.026	1000.0	-1000.0	-0.095	-1000.0
LPA receptor mediated events	21.0	2207.0	102.0	-0.089	0.028	1000.0	-1000.0	-0.041	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	21.0	1432.0	68.0	-0.211	0.077	1000.0	-1000.0	-0.074	-1000.0
p75(NTR)-mediated signaling	20.0	2539.0	125.0	-0.137	0.058	1000.0	-1000.0	-0.048	-1000.0
TCGA08_retinoblastoma	20.0	165.0	8.0	-0.02	0.021	1000.0	-1000.0	-0.002	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	19.0	1496.0	78.0	-0.102	0.046	1000.0	-1000.0	-0.043	-1000.0
Nectin adhesion pathway	18.0	1156.0	63.0	-0.059	0.06	1000.0	-1000.0	-0.044	-1000.0
Reelin signaling pathway	18.0	1056.0	56.0	-0.062	0.046	1000.0	-1000.0	-0.032	-1000.0
FOXM1 transcription factor network	18.0	929.0	51.0	-0.151	0.025	1000.0	-1000.0	-0.125	-1000.0
Thromboxane A2 receptor signaling	17.0	1854.0	105.0	-0.079	0.031	1000.0	-1000.0	-0.035	-1000.0
Plasma membrane estrogen receptor signaling	17.0	1534.0	86.0	-0.087	0.081	1000.0	-1000.0	-0.042	-1000.0
IL12-mediated signaling events	16.0	1477.0	87.0	-0.202	0.025	1000.0	-1000.0	-0.076	-1000.0
Glypican 1 network	16.0	788.0	48.0	-0.065	0.042	1000.0	-1000.0	-0.018	-1000.0
Signaling events regulated by Ret tyrosine kinase	16.0	1382.0	82.0	-0.047	0.025	1000.0	-1000.0	-0.044	-1000.0
BMP receptor signaling	15.0	1269.0	81.0	-0.084	0.046	1000.0	-1000.0	-0.04	-1000.0
IGF1 pathway	15.0	889.0	57.0	-0.033	0.039	1000.0	-1000.0	-0.032	-1000.0
Caspase cascade in apoptosis	14.0	1069.0	74.0	-0.087	0.036	1000.0	-1000.0	-0.035	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	14.0	477.0	34.0	-0.013	0.026	1000.0	-1000.0	-0.023	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1389.0	97.0	-0.053	0.04	1000.0	-1000.0	-0.042	-1000.0
Osteopontin-mediated events	13.0	495.0	38.0	-0.045	0.025	1000.0	-1000.0	-0.04	-1000.0
amb2 Integrin signaling	13.0	1074.0	82.0	-0.118	0.034	1000.0	-1000.0	-0.032	-1000.0
TCGA08_p53	13.0	91.0	7.0	-0.022	0.021	1000.0	-1000.0	-0.008	-1000.0
IL6-mediated signaling events	13.0	995.0	75.0	-0.162	0.059	1000.0	-1000.0	-0.047	-1000.0
BCR signaling pathway	13.0	1366.0	99.0	-0.066	0.033	1000.0	-1000.0	-0.054	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1644.0	120.0	-0.087	0.068	1000.0	-1000.0	-0.038	-1000.0
Syndecan-2-mediated signaling events	12.0	836.0	69.0	-0.03	0.034	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PTP1B	12.0	960.0	76.0	-0.064	0.028	1000.0	-1000.0	-0.024	-1000.0
Integrins in angiogenesis	12.0	1008.0	84.0	-0.067	0.042	1000.0	-1000.0	-0.034	-1000.0
Canonical Wnt signaling pathway	12.0	630.0	51.0	-0.127	0.066	1000.0	-1000.0	-0.044	-1000.0
Syndecan-4-mediated signaling events	12.0	851.0	67.0	-0.067	0.034	1000.0	-1000.0	-0.034	-1000.0
Arf6 signaling events	11.0	742.0	62.0	-0.023	0.039	1000.0	-1000.0	-0.023	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	11.0	621.0	52.0	-0.064	0.048	1000.0	-1000.0	-0.042	-1000.0
S1P1 pathway	11.0	403.0	36.0	-0.139	0.025	1000.0	-1000.0	-0.03	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	368.0	31.0	-0.1	0.025	1000.0	-1000.0	-0.021	-1000.0
Nongenotropic Androgen signaling	11.0	602.0	52.0	-0.039	0.035	1000.0	-1000.0	-0.028	-1000.0
EGFR-dependent Endothelin signaling events	11.0	236.0	21.0	-0.027	0.035	1000.0	-1000.0	-0.031	-1000.0
JNK signaling in the CD4+ TCR pathway	10.0	182.0	17.0	-0.036	0.036	1000.0	-1000.0	-0.029	-1000.0
Cellular roles of Anthrax toxin	10.0	411.0	39.0	-0.055	0.025	1000.0	-1000.0	-0.021	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	10.0	891.0	85.0	-0.027	0.025	1000.0	-1000.0	-0.039	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	652.0	61.0	-0.126	0.051	1000.0	-1000.0	-0.042	-1000.0
FAS signaling pathway (CD95)	10.0	484.0	47.0	-0.056	0.037	1000.0	-1000.0	-0.041	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	10.0	475.0	45.0	-0.038	0.065	1000.0	-1000.0	-0.039	-1000.0
PLK2 and PLK4 events	9.0	28.0	3.0	-0.002	-1000.0	1000.0	-1000.0	-0.001	-1000.0
IL1-mediated signaling events	9.0	611.0	62.0	-0.033	0.056	1000.0	-1000.0	-0.033	-1000.0
Retinoic acid receptors-mediated signaling	9.0	525.0	58.0	-0.047	0.048	1000.0	-1000.0	-0.033	-1000.0
IL2 signaling events mediated by PI3K	9.0	540.0	58.0	-0.058	0.033	1000.0	-1000.0	-0.039	-1000.0
Glypican 2 network	9.0	36.0	4.0	0.01	0.015	1000.0	-1000.0	0.012	-1000.0
ErbB2/ErbB3 signaling events	8.0	546.0	65.0	-0.04	0.046	1000.0	-1000.0	-0.055	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1170.0	136.0	-0.247	0.078	1000.0	-1000.0	-0.026	-1000.0
Coregulation of Androgen receptor activity	8.0	618.0	76.0	-0.069	0.039	1000.0	-1000.0	-0.019	-1000.0
BARD1 signaling events	8.0	507.0	57.0	-0.027	0.045	1000.0	-1000.0	-0.027	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	8.0	459.0	54.0	-0.062	0.036	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	8.0	471.0	55.0	-0.007	0.048	1000.0	-1000.0	-0.028	-1000.0
PDGFR-alpha signaling pathway	8.0	372.0	44.0	-0.041	0.042	1000.0	-1000.0	-0.036	-1000.0
IFN-gamma pathway	8.0	555.0	68.0	-0.048	0.048	1000.0	-1000.0	-0.051	-1000.0
Effects of Botulinum toxin	8.0	227.0	26.0	-0.045	0.038	1000.0	-1000.0	-0.003	-1000.0
Regulation of Androgen receptor activity	8.0	598.0	70.0	-0.087	0.032	1000.0	-1000.0	-0.045	-1000.0
Ras signaling in the CD4+ TCR pathway	8.0	137.0	17.0	-0.019	0.041	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	7.0	506.0	65.0	-0.196	0.054	1000.0	-1000.0	-0.04	-1000.0
Ceramide signaling pathway	7.0	587.0	76.0	-0.034	0.068	1000.0	-1000.0	-0.031	-1000.0
ceramide signaling pathway	7.0	356.0	49.0	-0.018	0.037	1000.0	-1000.0	-0.029	-1000.0
HIF-2-alpha transcription factor network	7.0	343.0	43.0	-0.042	0.053	1000.0	-1000.0	-0.044	-1000.0
IL27-mediated signaling events	7.0	407.0	51.0	-0.053	0.036	1000.0	-1000.0	-0.059	-1000.0
Regulation of Telomerase	7.0	739.0	102.0	-0.15	0.057	1000.0	-1000.0	-0.051	-1000.0
Angiopoietin receptor Tie2-mediated signaling	7.0	664.0	88.0	-0.054	0.034	1000.0	-1000.0	-0.054	-1000.0
Aurora B signaling	7.0	522.0	67.0	-0.154	0.061	1000.0	-1000.0	-0.027	-1000.0
LPA4-mediated signaling events	6.0	77.0	12.0	-0.036	0.007	1000.0	-1000.0	-0.019	-1000.0
PLK1 signaling events	6.0	516.0	85.0	-0.006	0.039	1000.0	-1000.0	-0.04	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	6.0	253.0	37.0	-0.027	0.05	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class III	6.0	252.0	40.0	-0.047	0.044	1000.0	-1000.0	-0.013	-1000.0
S1P5 pathway	6.0	114.0	17.0	-0.006	0.025	1000.0	-1000.0	-0.011	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	6.0	515.0	74.0	-0.045	0.051	1000.0	-1000.0	-0.05	-1000.0
IL2 signaling events mediated by STAT5	6.0	147.0	22.0	-0.029	0.026	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in keratinocytes	6.0	258.0	43.0	-0.014	0.039	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	6.0	155.0	25.0	-0.008	0.034	1000.0	-1000.0	-0.023	-1000.0
a4b1 and a4b7 Integrin signaling	5.0	27.0	5.0	0.011	0.025	1000.0	-1000.0	0.009	-1000.0
mTOR signaling pathway	5.0	287.0	53.0	-0.019	0.025	1000.0	-1000.0	-0.03	-1000.0
TRAIL signaling pathway	5.0	277.0	48.0	-0.002	0.05	1000.0	-1000.0	-0.023	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	75.0	15.0	-0.013	0.024	1000.0	-1000.0	-0.029	-1000.0
TCGA08_rtk_signaling	5.0	130.0	26.0	-0.037	0.052	1000.0	-1000.0	-0.006	-1000.0
Class I PI3K signaling events	5.0	401.0	73.0	-0.038	0.047	1000.0	-1000.0	-0.031	-1000.0
Insulin Pathway	5.0	413.0	74.0	-0.054	0.058	1000.0	-1000.0	-0.034	-1000.0
Visual signal transduction: Rods	5.0	290.0	52.0	-0.035	0.037	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by PRL	5.0	199.0	34.0	-0.044	0.037	1000.0	-1000.0	-0.039	-1000.0
Canonical NF-kappaB pathway	4.0	182.0	39.0	-0.018	0.054	1000.0	-1000.0	-0.024	-1000.0
ErbB4 signaling events	4.0	305.0	69.0	-0.026	0.029	1000.0	-1000.0	-0.036	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	131.0	28.0	-0.009	0.045	1000.0	-1000.0	-0.015	-1000.0
Arf6 downstream pathway	4.0	197.0	43.0	-0.036	0.04	1000.0	-1000.0	-0.022	-1000.0
FoxO family signaling	4.0	261.0	64.0	-0.103	0.051	1000.0	-1000.0	-0.053	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	158.0	36.0	-0.041	0.043	1000.0	-1000.0	-0.023	-1000.0
Syndecan-3-mediated signaling events	4.0	153.0	35.0	-0.032	0.051	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	523.0	125.0	-0.014	0.055	1000.0	-1000.0	-0.039	-1000.0
E-cadherin signaling in the nascent adherens junction	4.0	314.0	76.0	-0.024	0.055	1000.0	-1000.0	-0.045	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	135.0	33.0	-0.022	0.06	1000.0	-1000.0	-0.022	-1000.0
PDGFR-beta signaling pathway	4.0	444.0	97.0	-0.061	0.061	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	257.0	68.0	-0.031	0.047	1000.0	-1000.0	-0.028	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	260.0	83.0	-0.031	0.042	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class I	3.0	376.0	104.0	-0.039	0.062	1000.0	-1000.0	-0.028	-1000.0
Atypical NF-kappaB pathway	3.0	97.0	31.0	-0.0	0.025	1000.0	-1000.0	-0.014	-1000.0
Regulation of p38-alpha and p38-beta	3.0	215.0	54.0	-0.034	0.059	1000.0	-1000.0	-0.041	-1000.0
S1P3 pathway	3.0	154.0	42.0	-0.006	0.041	1000.0	-1000.0	-0.04	-1000.0
p38 MAPK signaling pathway	3.0	161.0	44.0	-0.048	0.045	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class II	2.0	222.0	75.0	-0.034	0.067	1000.0	-1000.0	-0.02	-1000.0
Visual signal transduction: Cones	2.0	96.0	38.0	-0.003	0.033	1000.0	-1000.0	-0.004	-1000.0
Aurora A signaling	2.0	135.0	60.0	-0.015	0.049	1000.0	-1000.0	-0.017	-1000.0
Aurora C signaling	2.0	19.0	7.0	-0.0	0.034	1000.0	-1000.0	-0.009	-1000.0
Insulin-mediated glucose transport	2.0	76.0	32.0	-0.008	0.041	1000.0	-1000.0	-0.024	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	2.0	75.0	27.0	-0.001	0.056	1000.0	-1000.0	-0.024	-1000.0
Arf6 trafficking events	2.0	193.0	71.0	-0.04	0.043	1000.0	-1000.0	-0.021	-1000.0
VEGFR1 specific signals	2.0	164.0	56.0	-0.014	0.048	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling events	2.0	13.0	5.0	0.02	0.039	1000.0	-1000.0	0.008	-1000.0
Arf1 pathway	2.0	111.0	54.0	-0.001	0.039	1000.0	-1000.0	-0.014	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	42.0	23.0	0.004	0.047	1000.0	-1000.0	-0.025	-1000.0
Circadian rhythm pathway	1.0	23.0	22.0	-0.008	0.045	1000.0	-1000.0	-0.034	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.022	0.022	1000.0	-1000.0	-0.013	-1000.0
Rapid glucocorticoid signaling	0.0	18.0	20.0	-0.0	0.026	1000.0	-1000.0	-0.003	-1000.0
Alternative NF-kappaB pathway	0.0	2.0	13.0	-0.0	0.067	1000.0	-1000.0	-0.0	-1000.0
Total	1366	85502	7203	-8.66054501773	-994.020748182	131000	-131000	-4.22839165339	-131000