Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.009 0.076 -9999.0 0.0 -0.284 6.0 6.0 epithelial cell differentiation -0.022 0.086 -9999.0 0.0 -0.356 6.0 6.0 CYFIP2 -0.021 0.142 -9999.0 0.0 -0.616 5.0 5.0 ENAH 0.026 0.102 -9999.0 0.0 -0.464 2.0 2.0 EGFR -0.056 0.187 -9999.0 0.0 -0.533 12.0 12.0 EPHA2 -0.023 0.152 -9999.0 0.0 -0.671 5.0 5.0 MYO6 0.011 0.09 -9999.0 0.0 -0.336 6.0 6.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.004 0.092 -9999.0 0.0 -0.423 4.0 4.0 AQP5 -0.033 0.085 -9999.0 0.0 -0.414 2.0 2.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.011 0.088 -9999.0 0.0 -0.331 6.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.13 -9999.0 0.0 -0.349 11.0 11.0 EGF -0.062 0.168 -9999.0 0.0 -0.429 16.0 16.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.101 0.222 -9999.0 0.0 -0.611 14.0 14.0 cortical microtubule organization -0.022 0.086 -9999.0 0.0 -0.356 6.0 6.0 GO:0000145 0.011 0.084 -9999.0 0.0 -0.316 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.005 0.094 -9999.0 0.0 -0.359 6.0 6.0 MLLT4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.038 0.125 -9999.0 0.0 -0.703 2.0 2.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.002 0.12 -9999.0 0.0 -0.443 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.019 0.089 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 -0.002 0.098 -9999.0 0.0 -0.671 2.0 2.0 ZYX 0.007 0.096 -9999.0 0.0 -0.336 7.0 7.0 ARF6/GTP -0.025 0.104 -9999.0 0.0 -0.406 6.0 6.0 CDH1 -0.031 0.165 -9999.0 0.0 -0.671 6.0 6.0 EGFR/EGFR/EGF/EGF -0.079 0.145 -9999.0 0.0 -0.409 12.0 12.0 RhoA/GDP -0.021 0.08 -9999.0 0.0 -0.332 6.0 6.0 actin cytoskeleton organization 0.013 0.092 -9999.0 0.0 -0.319 6.0 6.0 IGF-1R heterotetramer -0.031 0.165 -9999.0 0.0 -0.67 6.0 6.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.031 0.165 -9999.0 0.0 -0.671 6.0 6.0 IGF1 -0.1 0.221 -9999.0 0.0 -0.5 21.0 21.0 DIAPH1 -0.029 0.124 -9999.0 0.0 -0.62 4.0 4.0 Wnt receptor signaling pathway 0.022 0.086 0.356 6.0 -9999.0 0.0 6.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.038 0.125 -9999.0 0.0 -0.702 2.0 2.0 CTNNA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.013 0.094 -9999.0 0.0 -0.326 6.0 6.0 EFNA1 -0.002 0.098 -9999.0 0.0 -0.671 2.0 2.0 LPP 0.018 0.086 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.044 0.146 -9999.0 0.0 -0.422 10.0 10.0 SEC6/SEC8 -0.024 0.081 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.033 0.132 -9999.0 0.0 -0.354 11.0 11.0 HGF/MET -0.068 0.136 -9999.0 0.0 -0.355 16.0 16.0 HGF -0.09 0.221 -9999.0 0.0 -0.533 18.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.009 0.076 -9999.0 0.0 -0.286 6.0 6.0 actin cable formation 0.039 0.094 -9999.0 0.0 -0.344 3.0 3.0 KIAA1543 -0.025 0.2 -9999.0 0.0 -0.528 11.0 11.0 KIFC3 0.007 0.096 -9999.0 0.0 -0.336 7.0 7.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.011 0.09 -9999.0 0.0 -0.336 6.0 6.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.022 0.086 -9999.0 0.0 -0.356 6.0 6.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.011 0.09 -9999.0 0.0 -0.336 6.0 6.0 PIP5K1C 0.011 0.09 -9999.0 0.0 -0.336 6.0 6.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.018 0.12 -9999.0 0.0 -0.579 2.0 2.0 adherens junction assembly -0.015 0.194 -9999.0 0.0 -0.672 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.088 0.152 -9999.0 0.0 -0.368 19.0 19.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.007 0.074 -9999.0 0.0 -0.498 2.0 2.0 MET 0.005 0.069 -9999.0 0.0 -0.671 1.0 1.0 PLEKHA7 -0.015 0.163 -9999.0 0.0 -0.494 9.0 9.0 mol:GTP 0.001 0.119 -9999.0 0.0 -0.439 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.028 0.092 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.009 0.076 -9999.0 0.0 -0.284 6.0 6.0 regulation of cell-cell adhesion 0.013 0.092 -9999.0 0.0 -0.319 6.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.009 0.076 -9999.0 0.0 -0.286 6.0 6.0