Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
TCGA08_retinoblastoma	32.0	259.0	8.0	-0.295	0.151	1000.0	-1000.0	-0.015	-1000.0
TCGA08_p53	26.0	182.0	7.0	-0.222	0.116	1000.0	-1000.0	-0.012	-1000.0
Syndecan-1-mediated signaling events	17.0	583.0	34.0	-0.22	0.012	1000.0	-1000.0	-0.049	-1000.0
IL23-mediated signaling events	17.0	1072.0	60.0	-0.594	0.012	1000.0	-1000.0	-0.147	-1000.0
Wnt signaling	15.0	105.0	7.0	-0.143	0.005	1000.0	-1000.0	-0.026	-1000.0
IL4-mediated signaling events	13.0	1238.0	91.0	-0.628	0.57	1000.0	-1000.0	-0.168	-1000.0
IL12-mediated signaling events	12.0	1052.0	87.0	-0.344	0.076	1000.0	-1000.0	-0.108	-1000.0
Signaling events mediated by the Hedgehog family	12.0	668.0	52.0	-0.185	0.163	1000.0	-1000.0	-0.063	-1000.0
Glucocorticoid receptor regulatory network	11.0	1278.0	114.0	-0.607	0.352	1000.0	-1000.0	-0.065	-1000.0
Glypican 2 network	11.0	46.0	4.0	-0.053	-0.048	1000.0	-1000.0	-0.015	-1000.0
BMP receptor signaling	10.0	828.0	81.0	-0.265	0.028	1000.0	-1000.0	-0.085	-1000.0
amb2 Integrin signaling	10.0	856.0	82.0	-0.185	0.014	1000.0	-1000.0	-0.077	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	977.0	93.0	-0.191	0.104	1000.0	-1000.0	-0.076	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	687.0	68.0	-0.306	0.108	1000.0	-1000.0	-0.115	-1000.0
Noncanonical Wnt signaling pathway	9.0	247.0	26.0	-0.143	0.012	1000.0	-1000.0	-0.054	-1000.0
HIF-1-alpha transcription factor network	9.0	732.0	76.0	-0.444	0.019	1000.0	-1000.0	-0.136	-1000.0
Signaling mediated by p38-alpha and p38-beta	9.0	412.0	44.0	-0.125	0.012	1000.0	-1000.0	-0.043	-1000.0
Syndecan-4-mediated signaling events	9.0	662.0	67.0	-0.243	0.033	1000.0	-1000.0	-0.08	-1000.0
p75(NTR)-mediated signaling	8.0	1043.0	125.0	-0.199	0.036	1000.0	-1000.0	-0.091	-1000.0
Glypican 1 network	8.0	428.0	48.0	-0.218	0.013	1000.0	-1000.0	-0.041	-1000.0
Reelin signaling pathway	8.0	476.0	56.0	-0.164	0.028	1000.0	-1000.0	-0.074	-1000.0
BCR signaling pathway	8.0	881.0	99.0	-0.215	0.018	1000.0	-1000.0	-0.081	-1000.0
Caspase cascade in apoptosis	7.0	577.0	74.0	-0.124	0.065	1000.0	-1000.0	-0.036	-1000.0
Thromboxane A2 receptor signaling	7.0	750.0	105.0	-0.109	0.033	1000.0	-1000.0	-0.061	-1000.0
Fc-epsilon receptor I signaling in mast cells	7.0	708.0	97.0	-0.127	0.027	1000.0	-1000.0	-0.077	-1000.0
Signaling events regulated by Ret tyrosine kinase	7.0	598.0	82.0	-0.105	0.012	1000.0	-1000.0	-0.074	-1000.0
Endothelins	7.0	755.0	96.0	-0.164	0.022	1000.0	-1000.0	-0.072	-1000.0
EPHB forward signaling	7.0	644.0	85.0	-0.101	0.091	1000.0	-1000.0	-0.079	-1000.0
Calcium signaling in the CD4+ TCR pathway	7.0	221.0	31.0	-0.207	0.012	1000.0	-1000.0	-0.077	-1000.0
Visual signal transduction: Rods	7.0	383.0	52.0	-0.19	0.012	1000.0	-1000.0	-0.07	-1000.0
Class IB PI3K non-lipid kinase events	7.0	21.0	3.0	-0.038	-1000.0	1000.0	-1000.0	-0.013	-1000.0
IL1-mediated signaling events	6.0	418.0	62.0	-0.163	0.056	1000.0	-1000.0	-0.089	-1000.0
Ephrin B reverse signaling	6.0	290.0	48.0	-0.084	0.053	1000.0	-1000.0	-0.058	-1000.0
IL27-mediated signaling events	6.0	331.0	51.0	-0.324	0.059	1000.0	-1000.0	-0.078	-1000.0
LPA receptor mediated events	6.0	634.0	102.0	-0.14	0.03	1000.0	-1000.0	-0.077	-1000.0
EGFR-dependent Endothelin signaling events	6.0	131.0	21.0	-0.084	0.018	1000.0	-1000.0	-0.056	-1000.0
IGF1 pathway	6.0	373.0	57.0	-0.106	0.022	1000.0	-1000.0	-0.085	-1000.0
ErbB2/ErbB3 signaling events	5.0	343.0	65.0	-0.153	0.022	1000.0	-1000.0	-0.062	-1000.0
Coregulation of Androgen receptor activity	5.0	411.0	76.0	-0.327	0.022	1000.0	-1000.0	-0.042	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	5.0	182.0	34.0	-0.053	0.012	1000.0	-1000.0	-0.051	-1000.0
ErbB4 signaling events	5.0	383.0	69.0	-0.224	0.05	1000.0	-1000.0	-0.09	-1000.0
Osteopontin-mediated events	5.0	200.0	38.0	-0.083	0.012	1000.0	-1000.0	-0.092	-1000.0
Ephrin A  reverse signaling	5.0	36.0	7.0	-0.031	-0.0	1000.0	-1000.0	-0.021	-1000.0
Syndecan-2-mediated signaling events	5.0	362.0	69.0	-0.152	0.032	1000.0	-1000.0	-0.028	-1000.0
Arf6 signaling events	5.0	322.0	62.0	-0.09	0.012	1000.0	-1000.0	-0.05	-1000.0
Integrins in angiogenesis	5.0	429.0	84.0	-0.172	0.018	1000.0	-1000.0	-0.087	-1000.0
Nongenotropic Androgen signaling	5.0	282.0	52.0	-0.154	0.019	1000.0	-1000.0	-0.061	-1000.0
IL6-mediated signaling events	5.0	375.0	75.0	-0.122	0.056	1000.0	-1000.0	-0.088	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	5.0	388.0	74.0	-0.101	0.039	1000.0	-1000.0	-0.079	-1000.0
Rapid glucocorticoid signaling	5.0	108.0	20.0	-0.182	0.014	1000.0	-1000.0	-0.02	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	5.0	666.0	120.0	-0.176	0.131	1000.0	-1000.0	-0.065	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	5.0	437.0	78.0	-0.088	0.057	1000.0	-1000.0	-0.081	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	121.0	28.0	-0.087	0.017	1000.0	-1000.0	-0.03	-1000.0
JNK signaling in the CD4+ TCR pathway	4.0	82.0	17.0	-0.048	0.012	1000.0	-1000.0	-0.042	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	20.0	5.0	-0.02	0.001	1000.0	-1000.0	-0.019	-1000.0
FOXA2 and FOXA3 transcription factor networks	4.0	200.0	46.0	-0.31	0.018	1000.0	-1000.0	-0.096	-1000.0
Nectin adhesion pathway	4.0	281.0	63.0	-0.083	0.021	1000.0	-1000.0	-0.066	-1000.0
S1P5 pathway	4.0	81.0	17.0	-0.087	0.07	1000.0	-1000.0	-0.033	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	219.0	52.0	-0.169	0.034	1000.0	-1000.0	-0.044	-1000.0
Syndecan-3-mediated signaling events	4.0	156.0	35.0	-0.187	0.036	1000.0	-1000.0	-0.038	-1000.0
Effects of Botulinum toxin	4.0	108.0	26.0	-0.058	0.012	1000.0	-1000.0	-0.057	-1000.0
Plasma membrane estrogen receptor signaling	4.0	390.0	86.0	-0.1	0.022	1000.0	-1000.0	-0.075	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	4.0	143.0	33.0	-0.302	0.036	1000.0	-1000.0	-0.045	-1000.0
E-cadherin signaling events	4.0	21.0	5.0	-0.031	0.012	1000.0	-1000.0	-0.023	-1000.0
LPA4-mediated signaling events	3.0	38.0	12.0	-0.087	0.018	1000.0	-1000.0	-0.027	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	486.0	136.0	-0.246	0.086	1000.0	-1000.0	-0.073	-1000.0
Visual signal transduction: Cones	3.0	135.0	38.0	-0.045	0.012	1000.0	-1000.0	-0.054	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	3.0	189.0	54.0	-0.164	0.024	1000.0	-1000.0	-0.093	-1000.0
Signaling events mediated by PTP1B	3.0	294.0	76.0	-0.116	0.015	1000.0	-1000.0	-0.073	-1000.0
PDGFR-alpha signaling pathway	3.0	163.0	44.0	-0.052	0.02	1000.0	-1000.0	-0.057	-1000.0
S1P1 pathway	3.0	128.0	36.0	-0.089	0.012	1000.0	-1000.0	-0.053	-1000.0
FAS signaling pathway (CD95)	3.0	149.0	47.0	-0.182	0.013	1000.0	-1000.0	-0.032	-1000.0
Canonical Wnt signaling pathway	3.0	167.0	51.0	-0.119	0.045	1000.0	-1000.0	-0.054	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	347.0	88.0	-0.101	0.041	1000.0	-1000.0	-0.095	-1000.0
E-cadherin signaling in keratinocytes	3.0	159.0	43.0	-0.056	0.022	1000.0	-1000.0	-0.059	-1000.0
FOXM1 transcription factor network	3.0	166.0	51.0	-0.306	0.128	1000.0	-1000.0	-0.192	-1000.0
S1P4 pathway	3.0	94.0	25.0	-0.087	0.015	1000.0	-1000.0	-0.047	-1000.0
Regulation of Androgen receptor activity	3.0	275.0	70.0	-0.383	0.022	1000.0	-1000.0	-0.064	-1000.0
Ras signaling in the CD4+ TCR pathway	3.0	63.0	17.0	-0.047	0.022	1000.0	-1000.0	-0.036	-1000.0
Cellular roles of Anthrax toxin	2.0	110.0	39.0	-0.063	0.015	1000.0	-1000.0	-0.02	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	2.0	212.0	85.0	-0.09	0.02	1000.0	-1000.0	-0.072	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	161.0	65.0	-0.142	0.051	1000.0	-1000.0	-0.058	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	171.0	61.0	-0.119	0.033	1000.0	-1000.0	-0.078	-1000.0
IFN-gamma pathway	2.0	150.0	68.0	-0.074	0.024	1000.0	-1000.0	-0.092	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	83.0	37.0	-0.037	0.018	1000.0	-1000.0	-0.048	-1000.0
TRAIL signaling pathway	2.0	127.0	48.0	-0.043	0.033	1000.0	-1000.0	-0.06	-1000.0
HIF-2-alpha transcription factor network	2.0	126.0	43.0	-0.046	0.041	1000.0	-1000.0	-0.081	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	44.0	15.0	-0.019	0.017	1000.0	-1000.0	-0.03	-1000.0
IL2 signaling events mediated by PI3K	2.0	154.0	58.0	-0.091	0.03	1000.0	-1000.0	-0.082	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	124.0	45.0	-0.059	0.026	1000.0	-1000.0	-0.085	-1000.0
Regulation of p38-alpha and p38-beta	2.0	115.0	54.0	-0.07	0.029	1000.0	-1000.0	-0.059	-1000.0
TCGA08_rtk_signaling	2.0	53.0	26.0	-0.056	0.032	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	208.0	76.0	-0.051	0.028	1000.0	-1000.0	-0.078	-1000.0
IL2 signaling events mediated by STAT5	2.0	63.0	22.0	-0.105	0.016	1000.0	-1000.0	-0.044	-1000.0
Class I PI3K signaling events	2.0	156.0	73.0	-0.07	0.025	1000.0	-1000.0	-0.058	-1000.0
Regulation of Telomerase	2.0	260.0	102.0	-0.136	0.041	1000.0	-1000.0	-0.101	-1000.0
S1P3 pathway	2.0	114.0	42.0	-0.086	0.019	1000.0	-1000.0	-0.04	-1000.0
Aurora B signaling	2.0	147.0	67.0	-0.169	0.023	1000.0	-1000.0	-0.067	-1000.0
Canonical NF-kappaB pathway	1.0	48.0	39.0	-0.054	0.068	1000.0	-1000.0	-0.073	-1000.0
Signaling events mediated by HDAC Class II	1.0	94.0	75.0	-0.055	0.032	1000.0	-1000.0	-0.038	-1000.0
BARD1 signaling events	1.0	76.0	57.0	-0.013	0.057	1000.0	-1000.0	-0.06	-1000.0
Aurora C signaling	1.0	8.0	7.0	-0.009	0.005	1000.0	-1000.0	-0.027	-1000.0
EPO signaling pathway	1.0	60.0	55.0	-0.033	0.043	1000.0	-1000.0	-0.085	-1000.0
Ceramide signaling pathway	1.0	142.0	76.0	-0.1	0.021	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by HDAC Class III	1.0	73.0	40.0	-0.111	0.018	1000.0	-1000.0	-0.034	-1000.0
ceramide signaling pathway	1.0	57.0	49.0	-0.054	0.025	1000.0	-1000.0	-0.044	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	111.0	83.0	-0.067	0.037	1000.0	-1000.0	-0.068	-1000.0
Signaling events mediated by HDAC Class I	1.0	105.0	104.0	-0.079	0.051	1000.0	-1000.0	-0.061	-1000.0
Retinoic acid receptors-mediated signaling	1.0	77.0	58.0	-0.049	0.038	1000.0	-1000.0	-0.059	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	51.0	36.0	-0.029	0.025	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	138.0	125.0	-0.02	0.063	1000.0	-1000.0	-0.095	-1000.0
Arf6 trafficking events	1.0	82.0	71.0	-0.05	0.04	1000.0	-1000.0	-0.063	-1000.0
Insulin Pathway	1.0	115.0	74.0	-0.066	0.033	1000.0	-1000.0	-0.083	-1000.0
VEGFR1 specific signals	1.0	60.0	56.0	-0.02	0.045	1000.0	-1000.0	-0.056	-1000.0
PDGFR-beta signaling pathway	1.0	156.0	97.0	-0.045	0.05	1000.0	-1000.0	-0.079	-1000.0
Signaling events mediated by PRL	1.0	60.0	34.0	-0.11	0.032	1000.0	-1000.0	-0.039	-1000.0
p38 MAPK signaling pathway	1.0	66.0	44.0	-0.074	0.024	1000.0	-1000.0	-0.062	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.012	0.042	1000.0	-1000.0	-0.053	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.012	0.021	1000.0	-1000.0	-0.012	-1000.0
Circadian rhythm pathway	0.0	13.0	22.0	-0.02	0.039	1000.0	-1000.0	-0.05	-1000.0
Aurora A signaling	0.0	39.0	60.0	-0.034	0.033	1000.0	-1000.0	-0.047	-1000.0
Arf6 downstream pathway	0.0	17.0	43.0	-0.023	0.025	1000.0	-1000.0	-0.029	-1000.0
PLK1 signaling events	0.0	21.0	85.0	-0.005	0.034	1000.0	-1000.0	-0.039	-1000.0
Insulin-mediated glucose transport	0.0	31.0	32.0	-0.039	0.029	1000.0	-1000.0	-0.06	-1000.0
mTOR signaling pathway	0.0	22.0	53.0	-0.007	0.031	1000.0	-1000.0	-0.062	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	33.0	68.0	-0.039	0.044	1000.0	-1000.0	-0.057	-1000.0
FoxO family signaling	0.0	31.0	64.0	-0.061	0.128	1000.0	-1000.0	-0.069	-1000.0
Atypical NF-kappaB pathway	0.0	27.0	31.0	-0.013	0.032	1000.0	-1000.0	-0.035	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.005	0.03	1000.0	-1000.0	-0.045	-1000.0
Arf1 pathway	0.0	5.0	54.0	-0.003	0.028	1000.0	-1000.0	-0.029	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.036	1000.0	-1000.0	-0.037	-1000.0
Total	598	35548	7203	-16.5129998333	-994.59046903	131000	-131000	-8.05082344007	-131000