Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.033 0.196 -9999.0 0.0 -0.607 9.0 9.0 IHH 0.016 0.098 -9999.0 0.0 -0.522 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.06 0.136 -9999.0 0.0 -0.292 23.0 23.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.06 0.135 0.291 23.0 -9999.0 0.0 23.0 SMO/beta Arrestin2 -0.042 0.149 -9999.0 0.0 -0.42 6.0 6.0 SMO -0.053 0.147 -9999.0 0.0 -0.424 7.0 7.0 AKT1 -0.028 0.122 -9999.0 0.0 -0.415 5.0 5.0 ARRB2 0.023 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.051 0.146 -9999.0 0.0 -0.418 7.0 7.0 STIL -0.06 0.129 -9999.0 0.0 -0.366 5.0 5.0 DHH N/PTCH2 -0.0 0.116 -9999.0 0.0 -0.358 9.0 9.0 DHH N/PTCH1 -0.012 0.12 -9999.0 0.0 -0.283 14.0 14.0 PIK3CA 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.007 0.115 -9999.0 0.0 -0.492 5.0 5.0 PTHLH -0.069 0.298 -9999.0 0.0 -0.958 9.0 9.0 determination of left/right symmetry -0.051 0.146 -9999.0 0.0 -0.418 7.0 7.0 PIK3R1 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.068 0.294 -9999.0 0.0 -0.944 9.0 9.0 IHH N/Hhip -0.019 0.151 -9999.0 0.0 -0.384 13.0 13.0 DHH N/Hhip -0.029 0.154 -9999.0 0.0 -0.377 15.0 15.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.051 0.146 -9999.0 0.0 -0.418 7.0 7.0 pancreas development -0.036 0.166 -9999.0 0.0 -0.491 11.0 11.0 HHAT 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.012 0.136 -9999.0 0.0 -0.492 7.0 7.0 somite specification -0.051 0.146 -9999.0 0.0 -0.418 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.054 0.137 -9999.0 0.0 -0.279 20.0 20.0 SHH Np/Cholesterol/PTCH2 -0.044 0.131 -9999.0 0.0 -0.291 20.0 20.0 SHH Np/Cholesterol/Megalin -0.039 0.134 -9999.0 0.0 -0.305 18.0 18.0 SHH -0.07 0.135 -9999.0 0.0 -0.359 17.0 17.0 catabolic process -0.009 0.116 -9999.0 0.0 -0.331 10.0 10.0 SMO/Vitamin D3 -0.067 0.151 -9999.0 0.0 -0.406 8.0 8.0 SHH Np/Cholesterol/Hhip -0.066 0.156 -9999.0 0.0 -0.32 24.0 24.0 LRP2 0.01 0.092 -9999.0 0.0 -0.492 3.0 3.0 receptor-mediated endocytosis -0.076 0.155 -9999.0 0.0 -0.433 8.0 8.0 SHH Np/Cholesterol/BOC -0.029 0.11 -9999.0 0.0 -0.279 15.0 15.0 SHH Np/Cholesterol/CDO -0.038 0.124 -9999.0 0.0 -0.293 17.0 17.0 mesenchymal cell differentiation 0.066 0.155 0.318 24.0 -9999.0 0.0 24.0 mol:Vitamin D3 -0.049 0.144 0.354 1.0 -0.318 10.0 11.0 IHH N/PTCH2 0.011 0.106 -9999.0 0.0 -0.365 6.0 6.0 CDON 0.015 0.075 -9999.0 0.0 -0.492 2.0 2.0 IHH N/PTCH1 0.002 0.121 -9999.0 0.0 -0.326 11.0 11.0 Megalin/LRPAP1 0.026 0.071 -9999.0 0.0 -0.358 3.0 3.0 PTCH2 0.004 0.104 -9999.0 0.0 -0.492 4.0 4.0 SHH Np/Cholesterol -0.046 0.108 -9999.0 0.0 -0.275 17.0 17.0 PTCH1 -0.009 0.116 -9999.0 0.0 -0.332 10.0 10.0 HHIP -0.036 0.166 -9999.0 0.0 -0.492 11.0 11.0