Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.09 -9999.0 0.0 -0.254 45.0 45.0 epithelial cell differentiation 0.04 0.085 -9999.0 0.0 -0.291 25.0 25.0 CYFIP2 0.049 0.045 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.007 0.071 0.283 5.0 -0.32 1.0 6.0 EGFR -0.267 0.287 -9999.0 0.0 -0.543 264.0 264.0 EPHA2 0.026 0.063 -9999.0 0.0 -0.543 6.0 6.0 MYO6 0.001 0.073 -9999.0 0.0 -0.285 24.0 24.0 CTNNB1 0.03 0.045 -9999.0 0.0 -0.543 3.0 3.0 ABI1/Sra1/Nap1 0.073 0.034 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.141 0.236 -9999.0 0.0 -0.511 126.0 126.0 CTNND1 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.071 -9999.0 0.0 -0.28 24.0 24.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.105 -9999.0 0.0 -0.289 62.0 62.0 EGF -0.15 0.27 -9999.0 0.0 -0.543 162.0 162.0 NCKAP1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.052 0.178 -9999.0 0.0 -0.493 59.0 59.0 cortical microtubule organization 0.04 0.085 -9999.0 0.0 -0.291 25.0 25.0 GO:0000145 -0.021 0.063 -9999.0 0.0 -0.268 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.045 0.088 -9999.0 0.0 -0.293 25.0 25.0 MLLT4 0.029 0.046 -9999.0 0.0 -0.543 3.0 3.0 ARF6/GDP -0.029 0.057 -9999.0 0.0 -0.268 24.0 24.0 ARF6 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.057 0.058 -9999.0 0.0 -0.315 6.0 6.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.001 0.069 -9999.0 0.0 -0.421 1.0 1.0 PVRL2 0.038 0.026 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.002 0.072 -9999.0 0.0 -0.285 25.0 25.0 ARF6/GTP 0.062 0.061 -9999.0 0.0 -0.296 6.0 6.0 CDH1 0.006 0.119 -9999.0 0.0 -0.543 22.0 22.0 EGFR/EGFR/EGF/EGF -0.229 0.203 -9999.0 0.0 -0.346 352.0 352.0 RhoA/GDP 0.041 0.083 -9999.0 0.0 -0.282 24.0 24.0 actin cytoskeleton organization -0.021 0.067 -9999.0 0.0 -0.279 22.0 22.0 IGF-1R heterotetramer 0.01 0.116 -9999.0 0.0 -0.542 21.0 21.0 GIT1 0.032 0.011 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.117 -9999.0 0.0 -0.543 21.0 21.0 IGF1 -0.251 0.289 -9999.0 0.0 -0.543 250.0 250.0 DIAPH1 0.056 0.125 -9999.0 0.0 -0.56 7.0 7.0 Wnt receptor signaling pathway -0.04 0.085 0.291 25.0 -9999.0 0.0 25.0 RHOA 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.029 0.058 -9999.0 0.0 -0.271 19.0 19.0 CTNNA1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.021 0.068 -9999.0 0.0 -0.285 22.0 22.0 EFNA1 0.028 0.015 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.023 0.065 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 0.023 0.082 -9999.0 0.0 -0.286 25.0 25.0 SEC6/SEC8 -0.007 0.067 -9999.0 0.0 -0.273 22.0 22.0 MGAT3 -0.024 0.106 -9999.0 0.0 -0.293 62.0 62.0 HGF/MET 0.004 0.126 -9999.0 0.0 -0.29 72.0 72.0 HGF 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.091 -9999.0 0.0 -0.255 45.0 45.0 actin cable formation 0.054 0.108 0.344 17.0 -0.288 1.0 18.0 KIAA1543 -0.021 0.064 -9999.0 0.0 -0.272 24.0 24.0 KIFC3 0.001 0.069 -9999.0 0.0 -0.284 24.0 24.0 NCK1 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.032 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.001 0.071 -9999.0 0.0 -0.284 24.0 24.0 NCK1/GIT1 0.046 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.04 0.085 -9999.0 0.0 -0.291 25.0 25.0 EXOC4 0.034 0.005 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.002 0.07 -9999.0 0.0 -0.285 24.0 24.0 PIP5K1C -0.001 0.072 -9999.0 0.0 -0.284 24.0 24.0 LIMA1 0.012 0.11 -9999.0 0.0 -0.543 19.0 19.0 ABI1 0.033 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.014 0.103 0.304 13.0 -0.375 1.0 14.0 adherens junction assembly -0.03 0.127 0.297 1.0 -0.622 12.0 13.0 IGF-1R heterotetramer/IGF1 -0.131 0.184 -9999.0 0.0 -0.305 247.0 247.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.045 0.048 -9999.0 0.0 -0.248 9.0 9.0 MET -0.023 0.172 -9999.0 0.0 -0.543 50.0 50.0 PLEKHA7 -0.001 0.071 -9999.0 0.0 -0.284 24.0 24.0 mol:GTP 0.055 0.057 -9999.0 0.0 -0.313 6.0 6.0 establishment of epithelial cell apical/basal polarity -0.013 0.086 0.362 5.0 -0.351 1.0 6.0 cortical actin cytoskeleton stabilization -0.01 0.09 -9999.0 0.0 -0.254 45.0 45.0 regulation of cell-cell adhesion -0.021 0.067 -9999.0 0.0 -0.279 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.091 -9999.0 0.0 -0.255 45.0 45.0