Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.046 0.293 -9999.0 0.0 -0.838 91.0 91.0 IHH -0.011 0.076 -9999.0 0.0 -0.496 2.0 2.0 SHH Np/Cholesterol/GAS1 -0.031 0.121 -9999.0 0.0 -0.53 46.0 46.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.031 0.12 0.526 46.0 -9999.0 0.0 46.0 SMO/beta Arrestin2 -0.07 0.227 -9999.0 0.0 -0.866 57.0 57.0 SMO -0.046 0.254 -9999.0 0.0 -0.928 57.0 57.0 AKT1 0.0 0.093 -9999.0 0.0 -0.351 7.0 7.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.06 0.216 -9999.0 0.0 -0.838 60.0 60.0 ADRBK1 -0.0 0.01 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.028 0.251 -9999.0 0.0 -0.901 57.0 57.0 STIL -0.035 0.207 -9999.0 0.0 -0.725 59.0 59.0 DHH N/PTCH2 -0.073 0.213 -9999.0 0.0 -0.675 91.0 91.0 DHH N/PTCH1 -0.084 0.242 -9999.0 0.0 -0.768 82.0 82.0 PIK3CA -0.0 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.023 0.137 -9999.0 0.0 -0.838 23.0 23.0 PTHLH -0.07 0.366 -9999.0 0.0 -1.076 91.0 91.0 determination of left/right symmetry -0.028 0.251 -9999.0 0.0 -0.901 57.0 57.0 PIK3R1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.067 0.358 -9999.0 0.0 -1.053 91.0 91.0 IHH N/Hhip -0.009 0.048 -9999.0 0.0 -0.503 2.0 2.0 DHH N/Hhip -0.021 0.111 -9999.0 0.0 -0.657 24.0 24.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.028 0.251 -9999.0 0.0 -0.901 57.0 57.0 pancreas development -0.004 0.042 -9999.0 0.0 -0.328 11.0 11.0 HHAT -0.001 0.029 -9999.0 0.0 -0.838 1.0 1.0 PI3K -0.0 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.045 0.188 -9999.0 0.0 -0.838 45.0 45.0 somite specification -0.028 0.251 -9999.0 0.0 -0.901 57.0 57.0 SHH Np/Cholesterol/PTCH1 -0.066 0.202 -9999.0 0.0 -0.784 56.0 56.0 SHH Np/Cholesterol/PTCH2 -0.049 0.149 -9999.0 0.0 -0.526 74.0 74.0 SHH Np/Cholesterol/Megalin -0.142 0.228 -9999.0 0.0 -0.524 219.0 219.0 SHH 0.01 0.037 -9999.0 0.0 -0.654 1.0 1.0 catabolic process -0.041 0.253 -9999.0 0.0 -0.885 62.0 62.0 SMO/Vitamin D3 -0.069 0.221 -9999.0 0.0 -0.841 57.0 57.0 SHH Np/Cholesterol/Hhip -0.006 0.038 -9999.0 0.0 -0.528 2.0 2.0 LRP2 -0.224 0.365 -9999.0 0.0 -0.788 239.0 239.0 receptor-mediated endocytosis -0.146 0.251 -9999.0 0.0 -0.858 67.0 67.0 SHH Np/Cholesterol/BOC -0.041 0.138 -9999.0 0.0 -0.528 61.0 61.0 SHH Np/Cholesterol/CDO -0.01 0.062 -9999.0 0.0 -0.522 11.0 11.0 mesenchymal cell differentiation 0.006 0.037 0.523 2.0 -9999.0 0.0 2.0 mol:Vitamin D3 -0.025 0.218 -9999.0 0.0 -0.788 56.0 56.0 IHH N/PTCH2 -0.067 0.203 -9999.0 0.0 -0.717 73.0 73.0 CDON -0.01 0.091 -9999.0 0.0 -0.838 10.0 10.0 IHH N/PTCH1 -0.038 0.257 -9999.0 0.0 -0.894 62.0 62.0 Megalin/LRPAP1 -0.172 0.281 -9999.0 0.0 -0.645 218.0 218.0 PTCH2 -0.073 0.236 -9999.0 0.0 -0.838 73.0 73.0 SHH Np/Cholesterol -0.004 0.026 -9999.0 0.0 -0.533 1.0 1.0 PTCH1 -0.041 0.255 -9999.0 0.0 -0.891 62.0 62.0 HHIP -0.004 0.042 -9999.0 0.0 -0.329 11.0 11.0