E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.02 0.113 -9999.0 0.0 -0.408 37.0 37.0 KLHL20 0.016 0.069 0.238 9.0 -0.228 11.0 20.0 CYFIP2 0.029 0.044 0.265 21.0 -0.6 1.0 22.0 Rac1/GDP -0.0 0.087 0.263 6.0 -0.313 14.0 20.0 ENAH -0.017 0.106 -9999.0 0.0 -0.395 34.0 34.0 AP1M1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.008 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.013 0.033 -9999.0 0.0 -0.159 9.0 9.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.045 0.068 -9999.0 0.0 -0.356 16.0 16.0 RAPGEF1 -0.019 0.108 -9999.0 0.0 -0.406 24.0 24.0 CTNND1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.125 -9999.0 0.0 -0.414 43.0 43.0 CRK -0.017 0.103 -9999.0 0.0 -0.419 29.0 29.0 E-cadherin/gamma catenin/alpha catenin 0.032 0.063 -9999.0 0.0 -0.387 14.0 14.0 alphaE/beta7 Integrin 0.035 0.034 -9999.0 0.0 -0.447 2.0 2.0 IQGAP1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.041 0.023 -9999.0 0.0 -0.355 1.0 1.0 DLG1 -0.024 0.119 -9999.0 0.0 -0.407 41.0 41.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.016 0.028 -9999.0 0.0 -0.195 1.0 1.0 MLLT4 0.022 0.023 -9999.0 0.0 -0.6 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.043 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.042 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.02 0.068 -9999.0 0.0 -0.336 25.0 25.0 TIAM1 0.025 0.015 0.265 3.0 -9999.0 0.0 3.0 E-cadherin(dimer)/Ca2+ 0.04 0.058 -9999.0 0.0 -0.336 14.0 14.0 AKT1 -0.007 0.034 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.011 0.081 -9999.0 0.0 -0.6 14.0 14.0 RhoA/GDP 0.0 0.087 0.262 6.0 -0.314 14.0 20.0 actin cytoskeleton organization 0.015 0.056 0.189 18.0 -0.168 9.0 27.0 CDC42/GDP 0.0 0.086 0.263 5.0 -0.314 14.0 19.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.007 0.045 -9999.0 0.0 -0.241 25.0 25.0 ITGB7 0.027 0.045 0.265 15.0 -0.6 2.0 17.0 RAC1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.044 0.062 -9999.0 0.0 -0.356 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.029 0.054 -9999.0 0.0 -0.333 14.0 14.0 mol:GDP -0.014 0.094 0.269 6.0 -0.357 16.0 22.0 CDC42/GTP/IQGAP1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.089 0.27 1.0 -0.322 14.0 15.0 RAC1/GTP/IQGAP1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.05 0.193 29.0 -0.25 3.0 32.0 NME1 0.024 0.024 0.265 7.0 -9999.0 0.0 7.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.023 0.118 -9999.0 0.0 -0.414 38.0 38.0 regulation of cell-cell adhesion 0.003 0.041 -9999.0 0.0 -0.229 1.0 1.0 WASF2 0.007 0.028 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.012 0.059 -9999.0 0.0 -0.281 13.0 13.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.051 0.069 -9999.0 0.0 -0.339 16.0 16.0 CCND1 0.015 0.058 0.218 28.0 -0.317 3.0 31.0 VAV2 -0.021 0.155 -9999.0 0.0 -0.553 33.0 33.0 RAP1/GDP 0.005 0.072 0.265 3.0 -0.289 13.0 16.0 adherens junction assembly -0.022 0.114 -9999.0 0.0 -0.401 38.0 38.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.039 0.065 -9999.0 0.0 -0.328 16.0 16.0 E-cadherin/beta catenin -0.0 0.062 -9999.0 0.0 -0.348 24.0 24.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.024 0.119 -9999.0 0.0 -0.407 42.0 42.0 PIK3CA 0.024 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.006 0.095 0.273 27.0 -0.35 20.0 47.0 E-cadherin/beta catenin/alpha catenin 0.033 0.062 -9999.0 0.0 -0.387 14.0 14.0 ITGAE 0.022 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.127 -9999.0 0.0 -0.423 43.0 43.0