Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.196 0.322 -9999.0 0.0 -0.699 21.0 21.0 IHH -0.082 0.18 -9999.0 0.0 -0.557 11.0 11.0 SHH Np/Cholesterol/GAS1 -0.074 0.168 -9999.0 0.0 -0.435 11.0 11.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.074 0.166 0.432 11.0 -9999.0 0.0 11.0 SMO/beta Arrestin2 -0.141 0.232 -9999.0 0.0 -0.607 13.0 13.0 SMO -0.154 0.244 -9999.0 0.0 -0.646 13.0 13.0 AKT1 -0.064 0.136 -9999.0 0.0 -0.484 4.0 4.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.029 0.15 -9999.0 0.0 -0.563 7.0 7.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.152 0.24 -9999.0 0.0 -0.633 13.0 13.0 STIL -0.117 0.217 -9999.0 0.0 -0.579 12.0 12.0 DHH N/PTCH2 -0.014 0.115 -9999.0 0.0 -0.424 7.0 7.0 DHH N/PTCH1 -0.109 0.204 -9999.0 0.0 -0.533 12.0 12.0 PIK3CA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.006 0.098 -9999.0 0.0 -0.55 3.0 3.0 PTHLH -0.277 0.436 -9999.0 0.0 -0.997 22.0 22.0 determination of left/right symmetry -0.152 0.24 -9999.0 0.0 -0.633 13.0 13.0 PIK3R1 -0.017 0.127 -9999.0 0.0 -0.559 5.0 5.0 skeletal system development -0.273 0.429 -9999.0 0.0 -0.981 22.0 22.0 IHH N/Hhip -0.086 0.184 -9999.0 0.0 -0.471 16.0 16.0 DHH N/Hhip -0.043 0.151 -9999.0 0.0 -0.413 13.0 13.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.152 0.24 -9999.0 0.0 -0.633 13.0 13.0 pancreas development -0.056 0.169 -9999.0 0.0 -0.505 12.0 12.0 HHAT -0.008 0.113 -9999.0 0.0 -0.639 3.0 3.0 PI3K -0.003 0.094 -9999.0 0.0 -0.402 5.0 5.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.059 0.19 -9999.0 0.0 -0.561 12.0 12.0 somite specification -0.152 0.24 -9999.0 0.0 -0.633 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.13 0.228 -9999.0 0.0 -0.567 15.0 15.0 SHH Np/Cholesterol/PTCH2 -0.049 0.14 -9999.0 0.0 -0.327 19.0 19.0 SHH Np/Cholesterol/Megalin -0.069 0.154 -9999.0 0.0 -0.324 24.0 24.0 SHH -0.053 0.156 -9999.0 0.0 -0.4 16.0 16.0 catabolic process -0.118 0.213 -9999.0 0.0 -0.586 10.0 10.0 SMO/Vitamin D3 -0.151 0.242 -9999.0 0.0 -0.595 17.0 17.0 SHH Np/Cholesterol/Hhip -0.074 0.168 -9999.0 0.0 -0.406 16.0 16.0 LRP2 -0.049 0.164 -9999.0 0.0 -0.506 11.0 11.0 receptor-mediated endocytosis -0.162 0.226 -9999.0 0.0 -0.575 17.0 17.0 SHH Np/Cholesterol/BOC -0.058 0.148 -9999.0 0.0 -0.318 22.0 22.0 SHH Np/Cholesterol/CDO -0.042 0.129 -9999.0 0.0 -0.365 8.0 8.0 mesenchymal cell differentiation 0.074 0.166 0.403 16.0 -9999.0 0.0 16.0 mol:Vitamin D3 -0.129 0.23 -9999.0 0.0 -0.569 15.0 15.0 IHH N/PTCH2 -0.055 0.151 -9999.0 0.0 -0.464 9.0 9.0 CDON -0.001 0.093 -9999.0 0.0 -0.639 2.0 2.0 IHH N/PTCH1 -0.119 0.215 -9999.0 0.0 -0.593 10.0 10.0 Megalin/LRPAP1 -0.026 0.118 -9999.0 0.0 -0.357 11.0 11.0 PTCH2 -0.013 0.123 -9999.0 0.0 -0.605 4.0 4.0 SHH Np/Cholesterol -0.047 0.118 -9999.0 0.0 -0.31 16.0 16.0 PTCH1 -0.119 0.213 -9999.0 0.0 -0.589 10.0 10.0 HHIP -0.056 0.169 -9999.0 0.0 -0.506 12.0 12.0