Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.132 0.26 -9999.0 0.0 -0.629 17.0 17.0 IHH -0.03 0.1 -9999.0 0.0 -0.31 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.034 0.117 -9999.0 0.0 -0.361 9.0 9.0 LRPAP1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.034 0.116 0.359 9.0 -9999.0 0.0 9.0 SMO/beta Arrestin2 -0.118 0.212 -9999.0 0.0 -0.52 12.0 12.0 SMO -0.127 0.213 -9999.0 0.0 -0.532 13.0 13.0 AKT1 -0.071 0.164 -9999.0 0.0 -0.591 6.0 6.0 ARRB2 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.001 0.11 -9999.0 0.0 -0.425 5.0 5.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.124 0.211 -9999.0 0.0 -0.523 13.0 13.0 STIL -0.074 0.15 -9999.0 0.0 -0.393 11.0 11.0 DHH N/PTCH2 0.014 0.098 -9999.0 0.0 -0.422 4.0 4.0 DHH N/PTCH1 -0.066 0.156 -9999.0 0.0 -0.372 13.0 13.0 PIK3CA 0.018 0.014 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.071 -9999.0 0.0 -0.328 3.0 3.0 PTHLH -0.196 0.377 -9999.0 0.0 -0.902 19.0 19.0 determination of left/right symmetry -0.124 0.211 -9999.0 0.0 -0.523 13.0 13.0 PIK3R1 0.009 0.093 -9999.0 0.0 -0.388 4.0 4.0 skeletal system development -0.194 0.371 -9999.0 0.0 -0.889 19.0 19.0 IHH N/Hhip -0.024 0.092 -9999.0 0.0 -0.26 4.0 4.0 DHH N/Hhip 0.007 0.082 -9999.0 0.0 -0.313 3.0 3.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.124 0.211 -9999.0 0.0 -0.523 13.0 13.0 pancreas development -0.016 0.073 -9999.0 0.0 -0.206 11.0 11.0 HHAT 0.008 0.106 -9999.0 0.0 -0.571 3.0 3.0 PI3K 0.012 0.07 -9999.0 0.0 -0.422 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.019 0.143 -9999.0 0.0 -0.372 11.0 11.0 somite specification -0.124 0.211 -9999.0 0.0 -0.523 13.0 13.0 SHH Np/Cholesterol/PTCH1 -0.081 0.154 -9999.0 0.0 -0.384 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.02 0.097 -9999.0 0.0 -0.313 7.0 7.0 SHH Np/Cholesterol/Megalin -0.025 0.088 -9999.0 0.0 -0.276 7.0 7.0 SHH -0.035 0.093 -9999.0 0.0 -0.424 4.0 4.0 catabolic process -0.077 0.159 -9999.0 0.0 -0.371 17.0 17.0 SMO/Vitamin D3 -0.105 0.185 -9999.0 0.0 -0.468 14.0 14.0 SHH Np/Cholesterol/Hhip -0.031 0.091 -9999.0 0.0 -0.25 10.0 10.0 LRP2 -0.006 0.072 -9999.0 0.0 -0.206 10.0 10.0 receptor-mediated endocytosis -0.105 0.178 -9999.0 0.0 -0.476 12.0 12.0 SHH Np/Cholesterol/BOC -0.024 0.107 -9999.0 0.0 -0.382 6.0 6.0 SHH Np/Cholesterol/CDO -0.019 0.093 -9999.0 0.0 -0.333 6.0 6.0 mesenchymal cell differentiation 0.031 0.09 0.248 10.0 -9999.0 0.0 10.0 mol:Vitamin D3 -0.073 0.16 -9999.0 0.0 -0.384 14.0 14.0 IHH N/PTCH2 -0.016 0.109 -9999.0 0.0 -0.428 4.0 4.0 CDON 0.011 0.087 -9999.0 0.0 -0.571 2.0 2.0 IHH N/PTCH1 -0.066 0.165 -9999.0 0.0 -0.374 17.0 17.0 Megalin/LRPAP1 0.018 0.055 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.005 0.108 -9999.0 0.0 -0.479 4.0 4.0 SHH Np/Cholesterol -0.016 0.078 -9999.0 0.0 -0.33 4.0 4.0 PTCH1 -0.077 0.159 -9999.0 0.0 -0.372 17.0 17.0 HHIP -0.016 0.073 -9999.0 0.0 -0.206 11.0 11.0