Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.003 0.125 -9999.0 0.0 -0.671 2.0 2.0 epithelial cell differentiation -0.015 0.071 -9999.0 0.0 -0.394 2.0 2.0 CYFIP2 0.004 0.09 -9999.0 0.0 -0.636 3.0 3.0 ENAH 0.069 0.089 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.001 0.108 -9999.0 0.0 -0.661 4.0 4.0 EPHA2 -0.017 0.157 -9999.0 0.0 -0.739 7.0 7.0 MYO6 0.036 0.077 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.007 0.085 -9999.0 0.0 -0.739 2.0 2.0 ABI1/Sra1/Nap1 -0.01 0.065 -9999.0 0.0 -0.47 1.0 1.0 AQP5 -0.038 0.096 -9999.0 0.0 -0.59 1.0 1.0 CTNND1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.036 0.076 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.016 0.114 -9999.0 0.0 -0.616 1.0 1.0 EGF -0.207 0.326 -9999.0 0.0 -0.677 50.0 50.0 NCKAP1 0.012 0.061 -9999.0 0.0 -0.739 1.0 1.0 AQP3 -0.032 0.083 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.015 0.071 -9999.0 0.0 -0.394 2.0 2.0 GO:0000145 0.036 0.073 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.016 0.072 -9999.0 0.0 -0.399 2.0 2.0 MLLT4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.025 0.092 -9999.0 0.0 -0.575 2.0 2.0 ARF6 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 -0.019 0.087 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.051 0.076 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.034 0.084 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP -0.017 0.079 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.004 0.115 -9999.0 0.0 -0.636 5.0 5.0 EGFR/EGFR/EGF/EGF -0.121 0.161 -9999.0 0.0 -0.639 2.0 2.0 RhoA/GDP -0.014 0.065 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.046 0.074 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.358 0.323 -9999.0 0.0 -0.636 89.0 89.0 DIAPH1 -0.013 0.095 -9999.0 0.0 -0.669 3.0 3.0 Wnt receptor signaling pathway 0.015 0.071 0.394 2.0 -9999.0 0.0 2.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.025 0.092 -9999.0 0.0 -0.575 2.0 2.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.046 0.076 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.045 0.079 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.03 0.11 -9999.0 0.0 -0.672 2.0 2.0 SEC6/SEC8 -0.012 0.055 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.016 0.116 -9999.0 0.0 -0.63 1.0 1.0 HGF/MET -0.187 0.188 -9999.0 0.0 -0.694 3.0 3.0 HGF 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.004 0.126 -9999.0 0.0 -0.679 2.0 2.0 actin cable formation 0.09 0.083 -9999.0 0.0 -0.413 1.0 1.0 KIAA1543 0.045 0.087 -9999.0 0.0 -0.599 1.0 1.0 KIFC3 0.034 0.084 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.036 0.077 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.015 0.071 -9999.0 0.0 -0.394 2.0 2.0 EXOC4 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.036 0.077 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.077 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 -0.051 0.198 -9999.0 0.0 -0.636 16.0 16.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.021 0.079 -9999.0 0.0 -0.485 2.0 2.0 adherens junction assembly 0.065 0.089 -9999.0 0.0 -0.622 1.0 1.0 IGF-1R heterotetramer/IGF1 -0.175 0.155 -9999.0 0.0 -0.619 4.0 4.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.354 0.378 -9999.0 0.0 -0.739 76.0 76.0 PLEKHA7 0.036 0.077 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP -0.019 0.087 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.073 0.069 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.003 0.125 -9999.0 0.0 -0.671 2.0 2.0 regulation of cell-cell adhesion 0.046 0.074 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.004 0.126 -9999.0 0.0 -0.679 2.0 2.0