Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.048 0.213 -9999.0 0.0 -0.61 18.0 18.0 IHH -0.045 0.163 -9999.0 0.0 -0.506 20.0 20.0 SHH Np/Cholesterol/GAS1 -0.065 0.128 -9999.0 0.0 -0.243 63.0 63.0 LRPAP1 0.01 0.035 -9999.0 0.0 -0.47 1.0 1.0 dorsoventral neural tube patterning 0.065 0.127 0.242 63.0 -9999.0 0.0 63.0 SMO/beta Arrestin2 -0.035 0.185 -9999.0 0.0 -0.529 15.0 15.0 SMO -0.043 0.195 -9999.0 0.0 -0.563 15.0 15.0 AKT1 -0.007 0.118 -9999.0 0.0 -0.426 7.0 7.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.018 0.114 -9999.0 0.0 -0.44 13.0 13.0 ADRBK1 0.008 0.047 -9999.0 0.0 -0.452 2.0 2.0 heart looping -0.042 0.191 -9999.0 0.0 -0.552 15.0 15.0 STIL -0.022 0.145 -9999.0 0.0 -0.468 11.0 11.0 DHH N/PTCH2 -0.028 0.121 -9999.0 0.0 -0.335 25.0 25.0 DHH N/PTCH1 -0.04 0.146 -9999.0 0.0 -0.432 11.0 11.0 PIK3CA 0.01 0.035 -9999.0 0.0 -0.47 1.0 1.0 DHH -0.017 0.111 -9999.0 0.0 -0.447 12.0 12.0 PTHLH -0.075 0.281 -9999.0 0.0 -0.857 18.0 18.0 determination of left/right symmetry -0.042 0.191 -9999.0 0.0 -0.552 15.0 15.0 PIK3R1 0.008 0.049 -9999.0 0.0 -0.47 2.0 2.0 skeletal system development -0.073 0.277 -9999.0 0.0 -0.846 18.0 18.0 IHH N/Hhip -0.053 0.156 -9999.0 0.0 -0.363 36.0 36.0 DHH N/Hhip -0.038 0.129 -9999.0 0.0 -0.329 31.0 31.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.042 0.191 -9999.0 0.0 -0.552 15.0 15.0 pancreas development -0.037 0.146 -9999.0 0.0 -0.464 20.0 20.0 HHAT 0.005 0.06 -9999.0 0.0 -0.47 3.0 3.0 PI3K 0.013 0.043 -9999.0 0.0 -0.331 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.122 0.21 -9999.0 0.0 -0.449 56.0 56.0 somite specification -0.042 0.191 -9999.0 0.0 -0.552 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.026 0.151 -9999.0 0.0 -0.453 14.0 14.0 SHH Np/Cholesterol/PTCH2 -0.012 0.097 -9999.0 0.0 -0.269 22.0 22.0 SHH Np/Cholesterol/Megalin -0.016 0.087 -9999.0 0.0 -0.24 24.0 24.0 SHH 0.001 0.077 -9999.0 0.0 -0.326 10.0 10.0 catabolic process -0.034 0.157 -9999.0 0.0 -0.486 11.0 11.0 SMO/Vitamin D3 -0.032 0.176 -9999.0 0.0 -0.513 15.0 15.0 SHH Np/Cholesterol/Hhip -0.019 0.108 -9999.0 0.0 -0.279 26.0 26.0 LRP2 -0.03 0.118 -9999.0 0.0 -0.435 15.0 15.0 receptor-mediated endocytosis -0.037 0.174 -9999.0 0.0 -0.519 14.0 14.0 SHH Np/Cholesterol/BOC -0.009 0.089 -9999.0 0.0 -0.254 21.0 21.0 SHH Np/Cholesterol/CDO 0.004 0.065 -9999.0 0.0 -0.239 13.0 13.0 mesenchymal cell differentiation 0.019 0.107 0.277 26.0 -9999.0 0.0 26.0 mol:Vitamin D3 -0.024 0.153 -9999.0 0.0 -0.455 14.0 14.0 IHH N/PTCH2 -0.042 0.145 -9999.0 0.0 -0.356 31.0 31.0 CDON 0.005 0.057 -9999.0 0.0 -0.447 3.0 3.0 IHH N/PTCH1 -0.032 0.159 -9999.0 0.0 -0.49 11.0 11.0 Megalin/LRPAP1 -0.013 0.087 -9999.0 0.0 -0.302 16.0 16.0 PTCH2 -0.024 0.125 -9999.0 0.0 -0.454 15.0 15.0 SHH Np/Cholesterol 0.0 0.058 -9999.0 0.0 -0.248 10.0 10.0 PTCH1 -0.034 0.157 -9999.0 0.0 -0.488 11.0 11.0 HHIP -0.037 0.146 -9999.0 0.0 -0.465 20.0 20.0